دورية أكاديمية
An Overview and Therapeutic Promise of Nutraceuticals Against Sports-Related Brain Injury.
| العنوان: | An Overview and Therapeutic Promise of Nutraceuticals Against Sports-Related Brain Injury. |
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| المؤلفون: | Iqubal A; Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, ,India., Bansal P; Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, ,India., Iqubal MK; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, ,India., Pottoo FH; Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal, University, P.O.BOX 1982, Damman, 31441, ,Saudi Arabia., Haque SE; Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, ,India. |
| المصدر: | Current molecular pharmacology [Curr Mol Pharmacol] 2022; Vol. 15 (1), pp. 3-22. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101467997 Publication Model: Print Cited Medium: Internet ISSN: 1874-4702 (Electronic) Linking ISSN: 18744672 NLM ISO Abbreviation: Curr Mol Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers |
| مواضيع طبية MeSH: | Athletic Injuries*/complications , Athletic Injuries*/drug therapy , Athletic Injuries*/pathology , Brain Injuries*/diagnosis , Brain Injuries*/drug therapy , Brain Injuries*/pathology , Sports*, Brain/pathology ; Dietary Supplements ; Humans |
| مستخلص: | Sports-related traumatic brain injury (TBI) is one of the common neurological maladies experienced by athletes. Earlier, the term 'punch drunk syndrome' was used in the case TBI of boxers and now this term is replaced by chronic traumatic encephalopathy (CTE). Sports-related brain injury can either be short-term or long-term. A common instance of brain injury encompasses subdural hematoma, concussion, cognitive dysfunction, amnesia, headache, vision issue, axonopathy, or even death, if it remains undiagnosed or untreated. Further, chronic TBI may lead to pathogenesis of neuroinflammation and neurodegeneration via tauopathy, the formation of neurofibrillary tangles, and damage to the blood-brain barrier, microglial, and astrocyte activation. Thus, altered pathological, neurochemical, and neurometabolic attributes lead to the modulation of multiple signaling pathways and cause neurological dysfunction. Available pharmaceutical interventions are based on one drug one target hypothesis and are thereby unable to cover altered multiple signaling pathways. However, in recent times, pharmacological intervention of nutrients and nutraceuticals have been explored as they exert a multifactorial mode of action and maintain over homeostasis of the body. There are various reports available showing the positive therapeutic effect of nutraceuticals in sport-related brain injury. Therefore, in the current article, we have discussed the pathology, neurological consequence, sequelae, and perpetuation of sports-related brain injury. Further, we have discussed various nutraceutical supplements as well as available animal models to explore the neuroprotective effect/ upshots of these nutraceuticals in sports-related brain injury. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: Cognition; neurodegeneration; neuroinflammation; signaling pathway and natural products |
| تواريخ الأحداث: | Date Created: 20210204 Date Completed: 20220331 Latest Revision: 20220531 |
| رمز التحديث: | 20221213 |
| DOI: | 10.2174/1874467214666210203211914 |
| PMID: | 33538684 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1874-4702 |
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| DOI: | 10.2174/1874467214666210203211914 |