دورية أكاديمية
أعرض في EDS

Impact of post-diagnosis weight change on survival outcomes in Black and White breast cancer patients.

التفاصيل البيبلوغرافية
العنوان: Impact of post-diagnosis weight change on survival outcomes in Black and White breast cancer patients.
المؤلفون: Shang L; Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China., Hattori M; Department of Breast Oncology, Aichi Cancer Center, Nagoya, Japan., Fleming G; Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA., Jaskowiak N; Department of Surgery, University of Chicago, Chicago, IL, USA., Hedeker D; Department of Public Health Sciences, University of Chicago, 5841 S. Maryland Avenue, MC 2000, Chicago, IL, 60637, USA., Olopade OI; Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA., Huo D; Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA. dhuo@health.bsd.uchicago.edu.; Department of Public Health Sciences, University of Chicago, 5841 S. Maryland Avenue, MC 2000, Chicago, IL, 60637, USA. dhuo@health.bsd.uchicago.edu.
المصدر: Breast cancer research : BCR [Breast Cancer Res] 2021 Feb 04; Vol. 23 (1), pp. 18. Date of Electronic Publication: 2021 Feb 04.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100927353 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-542X (Electronic) Linking ISSN: 14655411 NLM ISO Abbreviation: Breast Cancer Res Subsets: MEDLINE
أسماء مطبوعة: Publication: London, UK : BioMed Central Ltd
Original Publication: London, UK : Current Science, c1999-
مواضيع طبية MeSH: Black People* , Body Weight* , White People*, Breast Neoplasms/*epidemiology, Adult ; Aged ; Aged, 80 and over ; Body Mass Index ; Body Weights and Measures ; Breast Neoplasms/diagnosis ; Breast Neoplasms/mortality ; Breast Neoplasms/therapy ; Case-Control Studies ; Comorbidity ; Female ; Humans ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models ; Registries ; Survival Analysis
مستخلص: Purpose: To evaluate weight change patterns over time following the diagnosis of breast cancer and to examine the association of post-diagnosis weight change and survival outcomes in Black and White patients.
Methods: The study included 2888 women diagnosed with non-metastatic breast cancer in 2000-2017 in Chicago. Longitudinal repeated measures of weight and height were collected, along with a questionnaire survey including questions on body size. Multilevel mixed-effects models were used to examine changes in body mass index (BMI). Delayed entry Cox proportional hazards models were used to investigate the impacts of changing slope of BMI on survival outcomes.
Results: At diagnosis, most patients were overweight or obese with a mean BMI of 27.5 kg/m 2 and 31.5 kg/m 2 for Blacks and Whites, respectively. Notably, about 45% of the patients had cachexia before death and substantial weight loss started about 30 months before death. In multivariable-adjusted analyses, compared to stable weight, BMI loss (> 0.5 kg/m 2 /year) showed greater than 2-fold increased risk in overall survival (hazard ratio [HR] = 2.60, 95% CI 1.88-3.59), breast cancer-specific survival (HR = 3.05, 95% CI 1.91-4.86), and disease-free survival (HR = 2.12, 95% CI 1.52-2.96). The associations were not modified by race, age at diagnosis, and pre-diagnostic weight. BMI gain (> 0.5 kg/m 2 /year) was also related to worse survival, but the effect was weak (HR = 1.60, 95% CI 1.10-2.33 for overall survival).
Conclusion: BMI loss is a strong predictor of worse breast cancer outcomes. Growing prevalence of obesity may hide diagnosis of cancer cachexia, which can occur in a large proportion of breast cancer patients long before death.
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معلومات مُعتمدة: P20 CA233307 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: Body mass index; Breast cancer; Prognosis; Racial disparities; Weight change
تواريخ الأحداث: Date Created: 20210205 Date Completed: 20220106 Latest Revision: 20230222
رمز التحديث: 20240513
مُعرف محوري في PubMed: PMC7863526
DOI: 10.1186/s13058-021-01397-9
PMID: 33541403
قاعدة البيانات: MEDLINE
الوصف
تدمد:1465-542X
DOI:10.1186/s13058-021-01397-9