دورية أكاديمية
أعرض في EDS

Translingual Neurostimulation for the Treatment of Chronic Symptoms Due to Mild-to-Moderate Traumatic Brain Injury.

التفاصيل البيبلوغرافية
العنوان: Translingual Neurostimulation for the Treatment of Chronic Symptoms Due to Mild-to-Moderate Traumatic Brain Injury.
المؤلفون: Tyler M; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin.; Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin., Skinner K; Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin., Prabhakaran V; Department of Radiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin., Kaczmarek K; Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin., Danilov Y; Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin.
المصدر: Archives of rehabilitation research and clinical translation [Arch Rehabil Res Clin Transl] 2019 Sep 27; Vol. 1 (3-4), pp. 100026. Date of Electronic Publication: 2019 Sep 27 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101763542 Publication Model: eCollection Cited Medium: Internet ISSN: 2590-1095 (Electronic) Linking ISSN: 25901095 NLM ISO Abbreviation: Arch Rehabil Res Clin Transl Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier Inc., [2019]-
مستخلص: Objective: To compare the efficacy of high- and low-frequency noninvasive translingual neurostimulation (TLNS) plus targeted physical therapy (PT) for treating chronic balance and gait deficits due to mild-to-moderate traumatic brain injury (mmTBI).
Design: Participants were randomized 1:1 in a 26-week double-blind phase 1/2 study (NCT02158494) with 3 consecutive treatment stages: in-clinic, at-home, and no treatment. Arms were high-frequency pulse (HFP) and low-frequency pulse (LFP) TLNS.
Setting: TLNS plus PT training was initiated in-clinic and then continued at home.
Participants: Participants (N=44; 18-65y) from across the United States were randomized into the HFP and LFP (each plus PT) arms. Forty-three participants (28 women, 15 men) completed at least 1 stage of the study. Enrollment requirements included an mmTBI ≥1 year prior to screening, balance disorder due to mmTBI, a plateau in recovery with current PT, and a Sensory Organization Test (SOT) score ≥16 points below normal.
Interventions: Participants received TLNS (HFP or LFP) plus PT for a total of 14 weeks (2 in-clinic and 12 at home), twice daily, followed by 12 weeks without treatment.
Main Outcome Measures: The primary endpoint was change in SOT composite score from baseline to week 14. Secondary variables (eg, Dynamic Gait Index [DGI], 6-minute walk test [6MWT]) were also collected.
Results: Both arms had a significant ( P <.0001) improvement in SOT scores from baseline at weeks 2, 5, 14 (primary endpoint), and 26. DGI scores had significant improvement ( P <.001-.01) from baseline at the same test points; 6MWT evaluations after 2 weeks were significant. The SOT, DGI, and 6MWT scores did not significantly differ between arms at any test point. There were no treatment-related serious adverse events.
Conclusions: Both the HFP+PT and LFP+PT groups had significantly improved balance scores, and outcomes were sustained for 12 weeks after discontinuing TLNS treatment. Results between arms did not significantly differ from each other. Whether the 2 dosages are equally effective or whether improvements are because of provision of PT cannot be conclusively established at this time.
(© 2019 The Authors.)
References: Neuropathol Appl Neurobiol. 2013 Oct;39(6):654-66. (PMID: 23231074)
Arch Phys Med Rehabil. 2014 Aug;95(8):1454-60. (PMID: 24769069)
Brain Inj. 2017;31(9):1188-1194. (PMID: 28981340)
Brain Inj. 1997 Sep;11(9):661-75. (PMID: 9376834)
J Vestib Res. 2004;14(5):397-409. (PMID: 15598995)
Iran Red Crescent Med J. 2014 Aug;16(8):e13579. (PMID: 25389476)
Arch Phys Med Rehabil. 2004 Feb;85(2):227-33. (PMID: 14966706)
Clin J Pain. 2009 Jan;25(1):12-9. (PMID: 19158541)
Otolaryngol Head Neck Surg. 2014 Nov;151(5):880-7. (PMID: 25205641)
PLoS One. 2018 Jul 11;13(7):e0198741. (PMID: 29995912)
CMAJ. 2011 May 17;183(8):905-11. (PMID: 21502355)
J Neurol Phys Ther. 2010 Jun;34(2):87-93. (PMID: 20588094)
Am J Phys Med Rehabil. 2003 May;82(5):385-90; quiz 391-2. (PMID: 12704280)
Pain. 2006 Jan;120(1-2):182-187. (PMID: 16360266)
Brain Inj. 2011;25(7-8):664-79. (PMID: 21561297)
MMWR Morb Mortal Wkly Rep. 2013 Jul 12;62(27):549-52. (PMID: 23842444)
Arch Phys Med Rehabil. 2003 Oct;84(10):1458-65. (PMID: 14586912)
Phys Ther. 2007 Jan;87(1):44-51. (PMID: 17142641)
Brain Stimul. 2013 Jul;6(4):631-40. (PMID: 23122916)
J Neurotrauma. 2018 Jun 1;35(11):1205-1212. (PMID: 29343158)
Brain Inj. 2005 Nov;19(12):989-1000. (PMID: 16263641)
Rheumatol Int. 1984;4(3):119-23. (PMID: 6611576)
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:559-62. (PMID: 19964939)
J Neurosurg. 2018 Apr 27;130(4):1080-1097. (PMID: 29701556)
Clin Neuropsychol. 2014;28(4):614-32. (PMID: 24625213)
Int J Phys Med Rehabil. 2016 Feb;4(1):. (PMID: 27019859)
N Engl J Med. 1990 Jun 7;322(23):1627-34. (PMID: 2140432)
Am J Sports Med. 2013 Jul;41(7):1497-504. (PMID: 23698389)
J Clin Epidemiol. 2000 Aug;53(8):786-92. (PMID: 10942860)
Concussion. 2018 Jan 18;3(1):CNC51. (PMID: 30202593)
J Clin Exp Neuropsychol. 2015;37(8):853-62. (PMID: 26245293)
Pain. 1983 Feb;15(2):157-65. (PMID: 6601789)
Laryngoscope. 2001 Oct;111(10):1812-7. (PMID: 11801950)
Headache. 2016 Sep;56(8):1317-32. (PMID: 27593728)
J Rehabil Res Dev. 2012;49(7):971-84. (PMID: 23341273)
Int J Rehabil Res. 2010 Jun;33(2):109-14. (PMID: 19593157)
Neurology. 2018 Jul 24;91(4):e364-e373. (PMID: 29907608)
J Neuroeng Rehabil. 2009 Mar 17;6:8. (PMID: 19292910)
J Neuroeng Rehabil. 2014 Jun 06;11:96. (PMID: 24906679)
JAMA Pediatr. 2016 Jul 1;170(7):647-53. (PMID: 27135397)
J Neuroeng Rehabil. 2014 May 01;11:79. (PMID: 24885412)
Clin J Sport Med. 2008 Mar;18(2):148-54. (PMID: 18332690)
Neurology. 2013 Feb 26;80(9):786-91. (PMID: 23365066)
Brain. 2008 Nov;131(Pt 11):2812-23. (PMID: 18567924)
Can Fam Physician. 2012 Mar;58(3):257-67, e128-40. (PMID: 22518895)
J Pain. 2001 Apr;2(2):128-33. (PMID: 14622834)
Brain Stimul. 2017 Nov - Dec;10(6):1133-1135. (PMID: 28923502)
Phys Ther. 1997 Aug;77(8):812-9. (PMID: 9256869)
Curr Opin Neurol. 2016 Dec;29(6):693-699. (PMID: 27608301)
J Neurotrauma. 2015 Dec 1;32(23):1834-48. (PMID: 25158206)
JAMA. 1999 Sep 8;282(10):954-7. (PMID: 10485680)
J Geriatr Phys Ther. 2011 Jul-Sep;34(3):131-7. (PMID: 21937903)
Restor Neurol Neurosci. 2015;33(4):435-45. (PMID: 26409403)
Neuropsychopharmacology. 2011 Jan;36(1):339-54. (PMID: 20592717)
Neurosci Lett. 2003 May 15;342(1-2):17-20. (PMID: 12727307)
Arch Phys Med Rehabil. 2015 Feb;96(2):379-80. (PMID: 25618196)
Anesthesiology. 1999 Nov;91(5):1232-8. (PMID: 10551571)
Eye Brain. 2016 Sep 06;8:153-164. (PMID: 28539811)
Sci Rep. 2017 Jul 28;7(1):6792. (PMID: 28754973)
Neuropsychiatr Dis Treat. 2015 Jun 30;11:1573-86. (PMID: 26170670)
Phys Ther. 2016 Nov;96(11):1753-1763. (PMID: 27197826)
Cephalalgia. 2018 Apr;38(5):959-969. (PMID: 29231763)
Arch Phys Med Rehabil. 2004 Oct;85(10):1662-6. (PMID: 15468028)
Brain Inj. 2015;29(2):238-48. (PMID: 25314613)
MMWR Surveill Summ. 2017 Mar 17;66(9):1-16. (PMID: 28301451)
فهرسة مساهمة: Keywords: 6MWT, 6-minute walk test*; AE, adverse event*; ANOVA, analysis of variance*; Balance*; DGI, Dynamic Gait Index*; Facial nerve*; Gait*; HFP, high-frequency pulse*; ITP, in-clinic training program*; LFP, low-frequency pulse*; Neurostimulation*; PSQI, Pittsburgh Sleep Quality Index*; PT, physical therapy*; PoNS, portable neuromodulation stimulator*; Rehabilitation*; SOT, Sensory Organization Test*; TBI, traumatic brain injury*; TLNS, translingual neurostimulation*; Trigeminal nerve*; mmTBI, mild-to-moderate traumatic brain injury*
تواريخ الأحداث: Date Created: 20210205 Latest Revision: 20240806
رمز التحديث: 20240806
مُعرف محوري في PubMed: PMC7853385
DOI: 10.1016/j.arrct.2019.100026
PMID: 33543056
قاعدة البيانات: MEDLINE
الوصف
تدمد:2590-1095
DOI:10.1016/j.arrct.2019.100026