دورية أكاديمية
أعرض في EDS

Changes in serum levels of Apo AIV in patients with newly diagnosed hyperthyroidism and hypothyroidism: a preliminary study.

التفاصيل البيبلوغرافية
العنوان: Changes in serum levels of Apo AIV in patients with newly diagnosed hyperthyroidism and hypothyroidism: a preliminary study.
المؤلفون: Kaykhaei MA; Department of Endocrinology and Metabolism, Zahedan University of Medical Sciences, Zahedan, Iran.; Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran., Ghezel A; Department of Endocrinology and Metabolism, Zahedan University of Medical Sciences, Zahedan, Iran., Ansari-Moghaddam A; Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran., Sandoughi M; Department of Rheumatology, Zahedan University of Medical Sciences, Zahedan, Iran., Sheikhi V; Department of Pediatric Nephrology, Zahedan University of Medical Sciences, Zahedan, Iran., Heidari Z; Department of Endocrinology and Metabolism, Zahedan University of Medical Sciences, Zahedan, Iran.; Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
المصدر: Hormone molecular biology and clinical investigation [Horm Mol Biol Clin Investig] 2021 Jan 27; Vol. 42 (2), pp. 175-181. Date of Electronic Publication: 2021 Jan 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: De Gruyter Country of Publication: Germany NLM ID: 101538885 Publication Model: Electronic Cited Medium: Internet ISSN: 1868-1891 (Electronic) Linking ISSN: 18681883 NLM ISO Abbreviation: Horm Mol Biol Clin Investig Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : De Gruyter
مواضيع طبية MeSH: Apolipoproteins A/*blood , Hyperthyroidism/*blood , Hypothyroidism/*blood, Adult ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Preliminary Data
مستخلص: Objectives: Apolipoprotein AIV has a role in chylomicrons and lipid secretion and catabolism. Also, Apo-AIV plays a role in the regulation of appetite and satiety. Previous studies on rats have shown that hyperthyroidism and hypothyroidism are associated with significant changes in Apo-AIV serum levels. There has been no research on serum Apo-AIV changes in hyper and hypothyroidism in humans.
Methods: This case-control study was performed on new patients with hyper and hypothyroidism. Eighteen patients with hyperthyroidism and 18 patients with hypothyroidism enrolled in the study. After 12 weeks treatment blood samples were recruited. If euthyroidism was achieved, serum Apo-AIV level was measured. Eighteen euthyroid healthy individuals without thyroid disease were chosen as the control group from general population.
Results: Serum levels of Apo-AIV before treatment in hypothyroidism, hyperthyroidism and in the control group were 85.61, 110.66 and 33.51 mg/dL respectively (p<0.001), which was significantly higher in hyperthyroid patients than hypothyroidism and control group. In patients with hyperthyroidism there was a significant decrease in serum levels of Apo-AIV after treatment (p=0.044). However in hypothyroidism a non-significant elevation in serum levels of Apo-AIV was observed (p=0.403). Furthermore, serum levels of Apo-AIV after treatment were significantly higher in both hyperthyroidism and hypothyroidism in comparison to control group (p<0.001).
Conclusions: The results of this study for the first time showed that the serum level of Apo-AIV is increased in patients with hyperthyroidism and is decreased in patients with hypothyroidism, and after treatment, there was a significant difference with the control group.
(© 2021 Walter de Gruyter GmbH, Berlin/Boston.)
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فهرسة مساهمة: Keywords: apolipoprotein AIV; hyperthyroidism; hypothyroidism
المشرفين على المادة: 0 (Apolipoproteins A)
0 (apolipoprotein A-IV)
تواريخ الأحداث: Date Created: 20210205 Date Completed: 20211228 Latest Revision: 20211228
رمز التحديث: 20240628
DOI: 10.1515/hmbci-2020-0044
PMID: 33544467
قاعدة البيانات: MEDLINE
الوصف
تدمد:1868-1891
DOI:10.1515/hmbci-2020-0044