دورية أكاديمية
أعرض في EDS

Enthesitis Related Arthritis in a Longitudinal Southeast Asian Registry: High Prevalence of HLA-B27, Different Sacroiliitis Risk Factors and Less Common Drug-Free Remission.

التفاصيل البيبلوغرافية
العنوان: Enthesitis Related Arthritis in a Longitudinal Southeast Asian Registry: High Prevalence of HLA-B27, Different Sacroiliitis Risk Factors and Less Common Drug-Free Remission.
المؤلفون: Arkachaisri T; Rheumatology and Immunology Service, Department of Pediatric Subspecialties, KK Women's and Children's Hospital, Singapore 229899, Singapore.; Duke-NUS Medical School, Pediatric Academic Clinical Program, Singapore 169857, Singapore., Teh KL; Rheumatology and Immunology Service, Department of Pediatric Subspecialties, KK Women's and Children's Hospital, Singapore 229899, Singapore., Book YX; Rheumatology and Immunology Service, Department of Pediatric Subspecialties, KK Women's and Children's Hospital, Singapore 229899, Singapore., Hoh SF; Division of Nursing, KK Women's and Children's Hospital, Singapore 229899, Singapore., Gao X; Division of Nursing, KK Women's and Children's Hospital, Singapore 229899, Singapore., Das L; Rheumatology and Immunology Service, Department of Pediatric Subspecialties, KK Women's and Children's Hospital, Singapore 229899, Singapore.
المصدر: Journal of clinical medicine [J Clin Med] 2021 Feb 03; Vol. 10 (4). Date of Electronic Publication: 2021 Feb 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2012]-
مستخلص: Objective . To describe the clinical characteristics, predictors and treatment of children with Enthesitis Related Arthritis (ERA) in a Singapore longitudinal cohort over 11 years. Methods . ERA patients were recruited from our registry (2009-2019). Nonparametric descriptive statistics including median (interquartile range, IQR) were used to describe data. Kaplan-Meier survival and logistic/Cox regression analyses were used to estimate the probabilities and determine predictors of clinical variables, respectively. The significance level was set at <0.05. Results . One hundred and forty-six ERA patients (87% male, 82% Chinese) were included. Median onset age was 11.9 years (IQR 9.4-14.0) and median disease duration was 4.9 years (IQR 2.6-8.3). Family history of Human Leukocyte Antigen (HLA)-B27 associated diseases was positive in 7.5%. Acute uveitis occurred in 3.4%. Oligoarthritis was present in 89.7%. Hip, knee and ankle joints were among the most common joints involved. One-fourth had enthesitis at diagnosis (Achilles tendon entheses, 82.9%). Sacroiliitis occurred in 61%. Probabilities of sacroiliitis development were 0.364, 0.448 and 0.578 at 1, 2 and 5 years after onset, respectively. Negative HLA-B27, female, older age at onset and hip arthritis at diagnosis were associated with shorter time for sacroiliitis development ( p = 0.001-0.049). Methotrexate (MTX) remained the most common disease modifying anti-rheumatic drug (DMARD) used (77.4%). However, 77.9% required anti-TNF (aTNF) therapy secondary to MTX failure. Among MTX-treated sacroiliitis patients, 85.3% failed, requiring aTNF, as compared to 63.2%patients without axial disease. Longer duration to diagnosis ( p = 0.038) and MTX use ( p = 0.007) predicted aTNF therapy. None had joint deformity. Conclusions . This study underscores differences in ERA clinical characteristics, predictors and treatment responses. Our ERA population had many unique findings but good functional outcomes.
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معلومات مُعتمدة: ILAR (2011) International League of Association for Rheumatology; 2011 National Arthritis Foundation of Singapore
فهرسة مساهمة: Keywords: Singapore; Southeast Asia; enthesitis-related arthritis; juvenile idiopathic arthritis; predictors; treatment
تواريخ الأحداث: Date Created: 20210206 Latest Revision: 20210303
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7913299
DOI: 10.3390/jcm10040568
PMID: 33546269
قاعدة البيانات: MEDLINE
الوصف
تدمد:2077-0383
DOI:10.3390/jcm10040568