دورية أكاديمية
أعرض في EDS

Sphingolipids as Regulators of Neuro-Inflammation and NADPH Oxidase 2.

التفاصيل البيبلوغرافية
العنوان: Sphingolipids as Regulators of Neuro-Inflammation and NADPH Oxidase 2.
المؤلفون: Arsenault EJ; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, 03824, USA., McGill CM; Department of Chemistry, University of Alaska Anchorage, Anchorage, AK, 99508, USA., Barth BM; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, 03824, USA. brian.barth@unh.edu.
المصدر: Neuromolecular medicine [Neuromolecular Med] 2021 Mar; Vol. 23 (1), pp. 25-46. Date of Electronic Publication: 2021 Feb 05.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 101135365 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1174 (Electronic) Linking ISSN: 15351084 NLM ISO Abbreviation: Neuromolecular Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Totowa, NJ : Humana Press, c2002-
مواضيع طبية MeSH: NADPH Oxidase 2/*metabolism , Neurodegenerative Diseases/*metabolism , Sphingolipids/*physiology, AIDS Dementia Complex/metabolism ; Animals ; Biological Products/therapeutic use ; Brain Diseases, Metabolic, Inborn/genetics ; Brain Diseases, Metabolic, Inborn/metabolism ; Brain Diseases, Metabolic, Inborn/therapy ; Drug Discovery ; Encephalitis, Viral/metabolism ; Enzyme Activation ; Enzyme Replacement Therapy ; Humans ; Inflammation ; Naphthalenes/therapeutic use ; Nerve Tissue Proteins/metabolism ; Neurodegenerative Diseases/therapy ; Neurons/metabolism ; Oxidation-Reduction ; Pyrimidinones/therapeutic use ; Reactive Oxygen Species/metabolism ; Zika Virus Infection/metabolism
مستخلص: Neuro-inflammation accompanies numerous neurological disorders and conditions where it can be associated with a progressive neurodegenerative pathology. In a similar manner, alterations in sphingolipid metabolism often accompany or are causative features in degenerative neurological conditions. These include dementias, motor disorders, autoimmune conditions, inherited metabolic disorders, viral infection, traumatic brain and spinal cord injury, psychiatric conditions, and more. Sphingolipids are major regulators of cellular fate and function in addition to being important structural components of membranes. Their metabolism and signaling pathways can also be regulated by inflammatory mediators. Therefore, as certain sphingolipids exert distinct and opposing cellular roles, alterations in their metabolism can have major consequences. Recently, regulation of bioactive sphingolipids by neuro-inflammatory mediators has been shown to activate a neuronal NADPH oxidase 2 (NOX2) that can provoke damaging oxidation. Therefore, the sphingolipid-regulated neuronal NOX2 serves as a mechanistic link between neuro-inflammation and neurodegeneration. Moreover, therapeutics directed at sphingolipid metabolism or the sphingolipid-regulated NOX2 have the potential to alleviate neurodegeneration arising out of neuro-inflammation.
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معلومات مُعتمدة: K22 CA190674 United States CA NCI NIH HHS; P01 CA171983 United States CA NCI NIH HHS; P30 CA044579 United States CA NCI NIH HHS; R03 CA252825 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: Ceramide; NADPH oxidase; Neuro-inflammation; Neurodegeneration; Sphingolipids
المشرفين على المادة: 0 (Biological Products)
0 (Naphthalenes)
0 (Nerve Tissue Proteins)
0 (Pyrimidinones)
0 (Reactive Oxygen Species)
0 (Sphingolipids)
0 (cambinol)
EC 1.6.3.- (CYBB protein, human)
EC 1.6.3.- (NADPH Oxidase 2)
تواريخ الأحداث: Date Created: 20210206 Date Completed: 20211122 Latest Revision: 20231018
رمز التحديث: 20231018
مُعرف محوري في PubMed: PMC9020407
DOI: 10.1007/s12017-021-08646-2
PMID: 33547562
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-1174
DOI:10.1007/s12017-021-08646-2