دورية أكاديمية
Assessment of The Role of Serum Neutrophil Gelatinase-Associated Lipocalin in Egyptian Childhood Bronchial Asthma: One Centre Study.
| العنوان: | Assessment of The Role of Serum Neutrophil Gelatinase-Associated Lipocalin in Egyptian Childhood Bronchial Asthma: One Centre Study. |
|---|---|
| المؤلفون: | Allam AA; Department of Medical Microbiology & Immunology Faculty of Medicine, Zagazig University, Zagazig, Egypt., Naguib MS; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Hegazy MS; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Fouad AM; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Yehia S; Departments of Medical Microbiology & Immunology Faculty of Medicine, Zagazig University, Zagazig, Egypt., Morad EA; Departments of Medical Microbiology & Immunology Faculty of Medicine, Zagazig University, Zagazig, Egypt. |
| المصدر: | The Egyptian journal of immunology [Egypt J Immunol] 2020 Jun; Vol. 27 (2), pp. 93-99. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Modern Commercial Press Country of Publication: Egypt NLM ID: 9816016 Publication Model: Print Cited Medium: Print ISSN: 1110-4902 (Print) NLM ISO Abbreviation: Egypt J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cairo : Modern Commercial Press, |
| مواضيع طبية MeSH: | Asthma*/blood , Asthma*/diagnosis, Lipocalin-2/*blood, Biomarkers ; Child ; Egypt ; Humans ; ROC Curve |
| مستخلص: | Neutrophil gelatinase-associated lipocalin (NGAL) is emerging as a potential biomarker in many medical conditions including asthma. The aim of this study was to assess the role of serum NGAL in Egyptian childhood bronchial asthma. The study included 156 patients and 39 apparently healthy control children. Full clinical examination, pulmonary function tests; CBC, CRP, IgE, liver function tests, and renal function tests, and serum NGAL level were performed. The difference between the studied groups was statistically significant regarding IgE, eosinophils and NGAL (P= 0.001 for each). In addition, the difference between the subgroup with severe persistent asthma and the subgroup with mild intermittent asthma was significant (P=0.001). ROC curve analysis showed that at a cut-off value of 0.884 the sensitivity and specificity of differentiating severe bronchial asthma patients from controls was 82 % and 76 %, respectively. In conclusion, NGAL may represent a potential marker of bronchial asthma in children with severe disease. (Copyright© by the Egyptian Association of Immunologists.) |
| المشرفين على المادة: | 0 (Biomarkers) 0 (LCN2 protein, human) 0 (Lipocalin-2) |
| تواريخ الأحداث: | Date Created: 20210207 Date Completed: 20210217 Latest Revision: 20210217 |
| رمز التحديث: | 20221213 |
| PMID: | 33548981 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1110-4902 |
|---|