دورية أكاديمية
Identification of S1PR3 gene signature involved in survival of sepsis patients.
| العنوان: | Identification of S1PR3 gene signature involved in survival of sepsis patients. |
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| المؤلفون: | Feng A; Department of Internal Medicine, College of Medicine-Phoenix, University of Arizona, 475 N. 5th Street, Phoenix, AZ, 85004, USA., Ma W; Department of Internal Medicine, College of Medicine-Phoenix, University of Arizona, 475 N. 5th Street, Phoenix, AZ, 85004, USA., Faraj R; Department of Internal Medicine, College of Medicine-Phoenix, University of Arizona, 475 N. 5th Street, Phoenix, AZ, 85004, USA., Kelly GT; Department of Internal Medicine, College of Medicine-Phoenix, University of Arizona, 475 N. 5th Street, Phoenix, AZ, 85004, USA., Black SM; Department of Medicine, College of Medicine-Tucson, University of Arizona, Tucson, AZ, USA., Fallon MB; Department of Internal Medicine, College of Medicine-Phoenix, University of Arizona, 475 N. 5th Street, Phoenix, AZ, 85004, USA., Wang T; Department of Internal Medicine, College of Medicine-Phoenix, University of Arizona, 475 N. 5th Street, Phoenix, AZ, 85004, USA. twang@arizona.edu. |
| المصدر: | BMC medical genomics [BMC Med Genomics] 2021 Feb 06; Vol. 14 (1), pp. 43. Date of Electronic Publication: 2021 Feb 06. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101319628 Publication Model: Electronic Cited Medium: Internet ISSN: 1755-8794 (Electronic) Linking ISSN: 17558794 NLM ISO Abbreviation: BMC Med Genomics |
| أسماء مطبوعة: | Original Publication: London : BioMed Central |
| مواضيع طبية MeSH: | Sepsis*/genetics , Sepsis*/mortality , Sepsis*/blood , Sphingosine-1-Phosphate Receptors*/genetics, Humans ; Prognosis ; Male ; Biomarkers/blood ; Female ; Receptors, Lysosphingolipid/genetics ; Receptors, Lysosphingolipid/metabolism ; Gene Expression Profiling ; Middle Aged ; Survival Analysis ; Aged |
| مستخلص: | Background: Sepsis is a life-threatening complication of infection that rapidly triggers tissue damage in multiple organ systems and leads to multi-organ deterioration. Up to date, prognostic biomarkers still have limitations in predicting the survival of patients with sepsis. We need to discover more prognostic biomarkers to improve the sensitivity and specificity of the prognosis of sepsis patients. Sphingosine-1-phosphate (S1P) receptor 3 (S1PR3), as one of the S1P receptors, is a prospective prognostic biomarker regulating sepsis-relevant events, including compromised vascular integrity, antigen presentation, and cytokine secretion. Until now, no S1PR3-related prognostic gene signatures for sepsis patients have been found. Methods: This study intends to obtain an S1PR3-associated gene signature from whole blood samples to be utilized as a probable prognostic tool for patients with sepsis. Results: We obtained an 18-gene S1PR3-related molecular signature (S3MS) from the intersection of S1PR3-associated genes and survival-associated genes. Numerous important immunity pathways that regulate the progression of sepsis are enriched among our 18 genes. Significantly, S3MS functions greatly in both the discovery and validation cohort. Furthermore, we demonstrated that S3MS obtains significantly better classification performance than random 18-gene signatures. Conclusions: Our results confirm the key role of S1PR3-associated genes in the development of sepsis, which will be a potential prognostic biomarker for patients with sepsis. Our results also focus on the classification performance of our S3MS as biomarkers for sepsis, which could also provide an early warning system for patients with sepsis. |
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| معلومات مُعتمدة: | P01 HL146369 United States HL NHLBI NIH HHS; P01 HL134610 United States HL NHLBI NIH HHS; P30 ES006694 United States ES NIEHS NIH HHS; R01 HL142212 United States HL NHLBI NIH HHS; T32 HL007249 United States HL NHLBI NIH HHS; R01 HL137282 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: Microarray; S1PR3; S3MS; Sepsis |
| المشرفين على المادة: | 0 (Sphingosine-1-Phosphate Receptors) 0 (sphingosine-1-phosphate receptor-3, human) 0 (Biomarkers) 0 (Receptors, Lysosphingolipid) |
| تواريخ الأحداث: | Date Created: 20210207 Date Completed: 20240724 Latest Revision: 20240726 |
| رمز التحديث: | 20240726 |
| مُعرف محوري في PubMed: | PMC7866676 |
| DOI: | 10.1186/s12920-021-00886-2 |
| PMID: | 33549110 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1755-8794 |
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| DOI: | 10.1186/s12920-021-00886-2 |