دورية أكاديمية
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Elucidating the Splitting Behavior of Tablets to Optimize the Pharmacotherapy in Veterinary Medicine.

التفاصيل البيبلوغرافية
العنوان: Elucidating the Splitting Behavior of Tablets to Optimize the Pharmacotherapy in Veterinary Medicine.
المؤلفون: Bedogni GR; Área Técnica Farmacéutica, Departamento de Farmacia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas, Godoy cruz, Argentina., Pires FQ; Laboratory of Food, Drug, and Cosmetics (LTMAC), School of Health Sciences, University of Brasilia, Brasília, DF, 70.910-900, Brazil., Chaker JA; Faculty of Ceilândia, University of Brasília (UnB), Brasília, DF, 72220-900, Brazil., Sa-Barreto LL; Faculty of Ceilândia, University of Brasília (UnB), Brasília, DF, 72220-900, Brazil., Seremeta K; Consejo Nacional de Investigaciones Científicas y Técnicas, Godoy cruz, Argentina.; Departamento de Ciencias Básicas y Aplicadas, Universidad Nacional del Chaco Austral, Cte. Fernández 755, 3700, Presidencia Roque Sáenz Peña, Chaco, Argentina., Okulik N; Consejo Nacional de Investigaciones Científicas y Técnicas, Godoy cruz, Argentina.; Departamento de Ciencias Básicas y Aplicadas, Universidad Nacional del Chaco Austral, Cte. Fernández 755, 3700, Presidencia Roque Sáenz Peña, Chaco, Argentina., Salomon CJ; Área Técnica Farmacéutica, Departamento de Farmacia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina. csalomon@fbioyf.unr.edu.ar.; Consejo Nacional de Investigaciones Científicas y Técnicas, Godoy cruz, Argentina. csalomon@fbioyf.unr.edu.ar., Cunha-Filho M; Laboratory of Food, Drug, and Cosmetics (LTMAC), School of Health Sciences, University of Brasilia, Brasília, DF, 70.910-900, Brazil. marciliofarm@hotmail.com.
المصدر: AAPS PharmSciTech [AAPS PharmSciTech] 2021 Feb 07; Vol. 22 (2), pp. 67. Date of Electronic Publication: 2021 Feb 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 100960111 Publication Model: Electronic Cited Medium: Internet ISSN: 1530-9932 (Electronic) Linking ISSN: 15309932 NLM ISO Abbreviation: AAPS PharmSciTech Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Springer
Original Publication: Arlington, VA : American Association of Pharmaceutical Scientists, c2000-
مواضيع طبية MeSH: Veterinary Medicine*, Tablets/*chemistry, Animals ; Drug Compounding/methods ; Hardness
مستخلص: It is well known that the splitting of tablets can bring serious risks to the health of the treated animals, e.g., the possible adverse reactions caused by overdoses of fenbendazole or aspirin. In this regard, this work aimed to evaluate, for the first time, the splitting behavior of commercial veterinary tablets and identifying the technological aspects that interfere in this process. Tablets were cut in halves using a tablet splitter and were analyzed regarding mass variation, mass loss, friability, and hardness. Microstructural and morphological evaluations were also performed. For most of the tablets, organic flavor additives provided more uniformity and cohesive matrix, which preserved its hardness after the cut and led to subdivision results within acceptable limits for mass measurements and friability. Apart from the microstructure, the most critical technological aspect for a correct splitting performance in such tablets was the presence of a score. Thus, the results presented here allow us to guide the manufacturing of veterinary drug products in order to produce tablets more adapted to the splitting process.
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فهرسة مساهمة: Keywords: companion animals; flavor additives; mass variation; splitting; veterinary tablet
المشرفين على المادة: 0 (Tablets)
تواريخ الأحداث: Date Created: 20210208 Date Completed: 20210325 Latest Revision: 20210325
رمز التحديث: 20221213
DOI: 10.1208/s12249-021-01937-8
PMID: 33554316
قاعدة البيانات: MEDLINE
الوصف
تدمد:1530-9932
DOI:10.1208/s12249-021-01937-8