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Westalsan: A New Acetylcholine Esterase Inhibitor from the Endophytic Fungus Westerdykella nigra.

التفاصيل البيبلوغرافية
العنوان: Westalsan: A New Acetylcholine Esterase Inhibitor from the Endophytic Fungus Westerdykella nigra.
المؤلفون: Sallam A; Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt., Sabry MA; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt., Galala AA; Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt.
المصدر: Chemistry & biodiversity [Chem Biodivers] 2021 Apr; Vol. 18 (4), pp. e2000957. Date of Electronic Publication: 2021 Mar 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004-
مواضيع طبية MeSH: Ascomycota/*chemistry , Cholinesterase Inhibitors/*pharmacology , Esterases/*antagonists & inhibitors, Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/isolation & purification ; Esterases/metabolism ; Molecular Conformation ; Molecular Docking Simulation
مستخلص: A new cytochalasan alkaloid, westalsan (1), along with two known cytochalasan compounds, phomacin B (2) and 19-hydroxy-19,20-dihydrophomacin C (3), were isolated from the solid rice culture of Westerdykella nigra, a marine-derived endophytic fungus, isolated from the roots of mangrove Avicennia marina (Forssk.) Vierh. The structures of compounds 1-3 were established on the basis of extensive 1D and 2D NMR spectroscopic techniques in combination with HR-ESI-MS. The ability of the isolated compounds to inhibit acetylcholine esterase activity was evaluated. Compound 3 showed the highest acetylcholine esterase inhibitory activity (IC 50 0.056±0.003 μM), followed by compound 1 (IC 50 0.088±0.005 μM) and compound 2 (IC 50 0.140±0.007 μM) compared to donepezil (IC 50 0.035±0.002 μM). This was further confirmed by molecular docking experiment.
(© 2021 Wiley-VHCA AG, Zurich, Switzerland.)
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معلومات مُعتمدة: Dr. Mohamed El-Metwally Division of Marine Environment, National Institute of Oceanography and Fisheries, Hurghada 84511, Egypt
فهرسة مساهمة: Keywords: Westerdykella nigra; acetylcholine esterase; cytochalasan; molecular docking
المشرفين على المادة: 0 (Cholinesterase Inhibitors)
EC 3.1.- (Esterases)
SCR Organism: Westerdykella nigra
تواريخ الأحداث: Date Created: 20210208 Date Completed: 20210726 Latest Revision: 20210726
رمز التحديث: 20221213
DOI: 10.1002/cbdv.202000957
PMID: 33555630
قاعدة البيانات: MEDLINE
الوصف
تدمد:1612-1880
DOI:10.1002/cbdv.202000957