دورية أكاديمية
Identification of Pathogens Potentially Associated with Non-Malarial Fever in Children: A Pilot Study in Peri-Urban Dakar, Senegal.
| العنوان: | Identification of Pathogens Potentially Associated with Non-Malarial Fever in Children: A Pilot Study in Peri-Urban Dakar, Senegal. |
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| المؤلفون: | Gildas Boris H; 1Unité d'Epidémiologie des Maladies Infectieuses, Institut Pasteur, Dakar, Senegal., Idrissa D; 2Pôle de Virologie, Institut Pasteur, Dakar, Senegal., Marie Louise S; 1Unité d'Epidémiologie des Maladies Infectieuses, Institut Pasteur, Dakar, Senegal., Cheikh T; 1Unité d'Epidémiologie des Maladies Infectieuses, Institut Pasteur, Dakar, Senegal., Mamadou Aliou B; 1Unité d'Epidémiologie des Maladies Infectieuses, Institut Pasteur, Dakar, Senegal., Fatoumata DS; 1Unité d'Epidémiologie des Maladies Infectieuses, Institut Pasteur, Dakar, Senegal., Rebecca G; 3Unité d'épidémiologie des Maladies émergentes, Institut Pasteur, Paris, France., Raymond B; 4Laboratoire de Biologie Médicale, Institut Pasteur, Dakar, Senegal., Diamilatou T; 1Unité d'Epidémiologie des Maladies Infectieuses, Institut Pasteur, Dakar, Senegal., Vincent R; 5Institut Pasteur, Paris, France., Oumar F; 2Pôle de Virologie, Institut Pasteur, Dakar, Senegal., Abdoulaye S; 4Laboratoire de Biologie Médicale, Institut Pasteur, Dakar, Senegal.; 6Faculté de Médecine, de Pharmacie et d'Odontologie, UCAD, Dakar, Senegal., Muriel V; 1Unité d'Epidémiologie des Maladies Infectieuses, Institut Pasteur, Dakar, Senegal.; 3Unité d'épidémiologie des Maladies émergentes, Institut Pasteur, Paris, France.; 7INSERM, Paris, France. |
| المصدر: | The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2021 Feb 08; Vol. 104 (4), pp. 1335-1341. Date of Electronic Publication: 2021 Feb 08. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-1645 (Electronic) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Northbrook, IL : American Society of Tropical Medicine and Hygiene Original Publication: Baltimore. |
| مواضيع طبية MeSH: | Bacteria/*isolation & purification , Bacterial Infections/*microbiology , Fever/*epidemiology , Fever/*etiology , Malaria/*epidemiology , Respiratory Tract Infections/*virology , Viruses/*isolation & purification, Bacteria/classification ; Bacteria/genetics ; Bacteria/pathogenicity ; Bacterial Infections/diagnosis ; Bacterial Infections/epidemiology ; Child, Preschool ; Coinfection/diagnosis ; Coinfection/epidemiology ; Coinfection/microbiology ; Coinfection/virology ; Cross-Sectional Studies ; Female ; Humans ; Infant ; Male ; Pilot Projects ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/epidemiology ; Senegal/epidemiology ; Viruses/classification ; Viruses/genetics ; Viruses/pathogenicity |
| مستخلص: | Fever is one of the most common reasons for pediatric consultation in Africa. Malaria incidence has now dropped considerably, yet etiologies of non-malarial febrile diseases are poorly documented. This pilot study aimed to 1) identify pathogens potentially associated with non-malarial fever in children younger than 10 years in the suburbs of Dakar and 2) describe the epidemiological characteristics of these patients. During the study period, all eligible children (< 10 years of age, body temperature ≥ 38°C, negative result for the malaria rapid diagnostic test, living in Guediawaye/Pikine for the previous four calendar months, not receiving any anti-infectious treatment since the onset of fever, and with parent's consent to participate) presenting to the health post in Medina Gounass located in Guediawaye on Mondays and Fridays were included. In total, 106 children participated in the study, and PCR from nasopharyngeal swabs, hemoculture, C-reactive protein, blood cell counts, and quantitative buffy coat from blood samples and coproculture from stool samples were performed. In 70 (66%) children, at least one pathogen was isolated. Viruses were identified in 55 children, most commonly enteroviruses, rhinoviruses, and adenoviruses, and dengue virus was identified in three children. Only five children had bacterial infections, and 10 had bacterial and viral coinfections. Ninety-seven children (92%) received prescription for antibiotics. Many strains of bacteria were found to be resistant to several antibiotics. Despite limitations, this pilot study showed that pathogens potentially associated with non-malarial fever in children younger than 10 years near Dakar were predominantly viruses, most commonly upper respiratory infections, although bacteria accounted for a small proportion. |
| تواريخ الأحداث: | Date Created: 20210208 Date Completed: 20220215 Latest Revision: 20220402 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8045601 |
| DOI: | 10.4269/ajtmh.19-0963 |
| PMID: | 33556036 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1476-1645 |
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| DOI: | 10.4269/ajtmh.19-0963 |