دورية أكاديمية
IL-10 Signaling in the Tumor Microenvironment of Ovarian Cancer.
العنوان: | IL-10 Signaling in the Tumor Microenvironment of Ovarian Cancer. |
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المؤلفون: | Batchu RB; Wayne State University School of Medicine, Detroit, MI, USA. bb9067@wayne.edu.; John D. Dingell VA Medical Center, Detroit, MI, USA. bb9067@wayne.edu., Gruzdyn OV; Wayne State University School of Medicine, Detroit, MI, USA.; John D. Dingell VA Medical Center, Detroit, MI, USA., Kolli BK; Wayne State University School of Medicine, Detroit, MI, USA.; John D. Dingell VA Medical Center, Detroit, MI, USA.; Med Manor Organics Pvt. Ltd., Hyderabad, India., Dachepalli R; Med Manor Organics Pvt. Ltd., Hyderabad, India., Umar PS; Med Manor Organics Pvt. Ltd., Hyderabad, India., Rai SK; Med Manor Organics Pvt. Ltd., Hyderabad, India., Singh N; Med Manor Organics Pvt. Ltd., Hyderabad, India., Tavva PS; Med Manor Organics Pvt. Ltd., Hyderabad, India., Weaver DW; Wayne State University School of Medicine, Detroit, MI, USA., Gruber SA; Wayne State University School of Medicine, Detroit, MI, USA.; John D. Dingell VA Medical Center, Detroit, MI, USA. |
المصدر: | Advances in experimental medicine and biology [Adv Exp Med Biol] 2021; Vol. 1290, pp. 51-65. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0121103 Publication Model: Print Cited Medium: Print ISSN: 0065-2598 (Print) Linking ISSN: 00652598 NLM ISO Abbreviation: Adv Exp Med Biol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 1998- : New York : Kluwer Academic/Plenum Publishers Original Publication: New York, Plenum Press. |
مواضيع طبية MeSH: | Interleukin-10* , Ovarian Neoplasms*/therapy, Carcinoma, Ovarian Epithelial ; Dendritic Cells ; Female ; Humans ; Signal Transduction ; Tumor Microenvironment |
مستخلص: | Unlike other malignancies, ovarian cancer (OC) creates a complex tumor microenvironment with distinctive peritoneal ascites consisting of a mixture of several immunosuppressive cells which impair the ability of the patient's immune system to fight the disease. The poor survival rates observed in advanced stage OC patients and the lack of effective conventional therapeutic options have been attributed in large part to the immature dendritic cells (DCs), IL-10 secreting regulatory T cells, tumor-associated macrophages, myeloid-derived suppressor cells, and cancer stem cells that secrete inhibitory cytokines. This review highlights the critical role played by the intraperitoneal presence of IL-10 in the generation of an immunosuppressive tumor microenvironment. Further, the effect of antibody neutralization of IL-10 on the efficacy of DC and chimeric antigen receptor T-cell vaccines will be discussed. Moreover, we will review the influence of IL-10 in the promotion of cancer stemness in concert with the NF-κB signaling pathway with regard to OC progression. Finally, understanding the role of IL-10 and its crosstalk with various cells in the ascitic fluid may contribute to the development of novel immunotherapeutic approaches with the potential to kill drug-resistant OC cells while minimizing toxic side effects. |
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فهرسة مساهمة: | Keywords: CD4+ T cells; CD8+ cytotoxic T cells; Cancer stem cells; Chemokines; Chimeric antigen receptor T cells; Cytokines; Dendritic cells; Epithelial-to-mesenchymal transition; Immunosurveillance; Immunotherapy; Interferon-γ; Interleukin-10; Interleukin-12; Interleukins; Janus kinase-signal transducer and activator of transcription 3 pathway; Mesothelin; Nuclear factor-κB; Ovarian cancer; Regulatory T cells; Transforming growth factor -β; Tumor microenvironment |
المشرفين على المادة: | 0 (IL10 protein, human) 130068-27-8 (Interleukin-10) |
تواريخ الأحداث: | Date Created: 20210209 Date Completed: 20210215 Latest Revision: 20220531 |
رمز التحديث: | 20231215 |
DOI: | 10.1007/978-3-030-55617-4_3 |
PMID: | 33559854 |
قاعدة البيانات: | MEDLINE |
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