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New Polyenes from the Marine-Derived Fungus Talaromyces cyanescens with Anti-Neuroinflammatory and Cytotoxic Activities.

التفاصيل البيبلوغرافية
العنوان: New Polyenes from the Marine-Derived Fungus Talaromyces cyanescens with Anti-Neuroinflammatory and Cytotoxic Activities.
المؤلفون: Shin HJ; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Korea.; Department of Marine Biotechnology, University of Science and Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon 34113, Korea., Anh CV; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Korea.; Department of Marine Biotechnology, University of Science and Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon 34113, Korea., Cho DY; Department of Applied Life Science, Graduate school, BK21 Program, Konkuk University, Chungju 27478, Korea., Choi DK; Department of Applied Life Science, Graduate school, BK21 Program, Konkuk University, Chungju 27478, Korea., Kang JS; Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea., Trinh PTH; Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, 02 Hung Vuong, Nha Trang 650000, Vietnam., Choi BK; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Korea., Lee HS; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Korea.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2021 Feb 05; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Anti-Inflammatory Agents/*pharmacology , Antineoplastic Agents/*pharmacology , Polyenes/*pharmacology , Talaromyces/*chemistry, Anti-Inflammatory Agents/therapeutic use ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Inflammation/drug therapy ; Polyenes/therapeutic use
مستخلص: Three new polyene compounds, talacyanols A-C ( 1 - 3 ), along with two known compounds, ramulosin ( 4 ) and eurothiocin A ( 5 ), were isolated from the marine fungus Talaromyces cyanescens derived from a seaweed Caulerpa sp. Structures of 1 - 5 were established by one-dimensional and two-dimensional (1D/2D) NMR, HR-ESIMS, and the modified Mosher's methods, as well as comparison with previously reported literature data. All the compounds ( 1 - 5 ) were tested for their in vitro cytotoxic and anti-neuroinflammatory activities. Among them, 1 showed moderate cytotoxic activity against a panel of cancer cell lines (HCT-15, NUGC-3, NCI-H23, ACHN, PC-3, and MDA-MB-231) with GI 50 values ranging from 44.4 to 91.6 μM, whereas compounds 2 and 5 exhibited anti-neuroinflammatory effect without cytotoxicity against all the tested cell lines.
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معلومات مُعتمدة: PE99852 Korea Institute of Ocean Science and Technology; PM59122 Ministry of Oceans and Fisheries
فهرسة مساهمة: Keywords: Talaromyces cyanescens; anti-neuroinflammatory; cytotoxicity; marine-derived fungus; polyenes
المشرفين على المادة: 0 (Anti-Inflammatory Agents)
0 (Antineoplastic Agents)
0 (Polyenes)
SCR Organism: Talaromyces cyanescens
تواريخ الأحداث: Date Created: 20210210 Date Completed: 20210511 Latest Revision: 20210511
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7915668
DOI: 10.3390/molecules26040836
PMID: 33562648
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules26040836