Quantification of Myocardial Creatine and Triglyceride Content in the Human Heart: Precision and Accuracy of in vivo Proton Magnetic Resonance Spectroscopy.

التفاصيل البيبلوغرافية
العنوان:	Quantification of Myocardial Creatine and Triglyceride Content in the Human Heart: Precision and Accuracy of in vivo Proton Magnetic Resonance Spectroscopy.
المؤلفون:	Bakermans AJ; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Boekholdt SM; Department of Cardiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., de Vries DK; Department of Experimental Cardiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Reckman YJ; Department of Experimental Cardiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Farag ES; Department of Cardiothoracic Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., de Heer P; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.; C.J. Gorter Center for High Field MR, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands., Uthman L; Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Denis SW; Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Zuurbier CJ; Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Houtkooper RH; Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Koolbergen DR; Department of Cardiothoracic Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Kluin J; Department of Cardiothoracic Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Planken RN; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Lamb HJ; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands., Webb AG; C.J. Gorter Center for High Field MR, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands., Strijkers GJ; Biomedical Engineering and Physics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Beard DA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA., Jeneson JAL; Neuroimaging Center, Department of Neuroscience, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Nederveen AJ; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
المصدر:	Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2021 Aug; Vol. 54 (2), pp. 411-420. Date of Electronic Publication: 2021 Feb 10.
نوع المنشور:	Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: Wiley-Liss Country of Publication: United States NLM ID: 9105850 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-2586 (Electronic) Linking ISSN: 10531807 NLM ISO Abbreviation: J Magn Reson Imaging Subsets: MEDLINE
أسماء مطبوعة:	Publication: <2005-> : Hoboken , N.J. : Wiley-Liss Original Publication: Chicago, IL : Society for Magnetic Resonance Imaging, c1991-
مواضيع طبية MeSH:	Creatine* , Myocardium*, Heart/diagnostic imaging ; Humans ; Proton Magnetic Resonance Spectroscopy ; Triglycerides
مستخلص:	Background: Proton magnetic resonance spectroscopy ( ¹ H-MRS) of the human heart is deemed to be a quantitative method to investigate myocardial metabolite content, but thorough validations of in vivo measurements against invasive techniques are lacking. Purpose: To determine measurement precision and accuracy for quantifications of myocardial total creatine and triglyceride content with localized ¹ H-MRS. Study Type: Test-retest repeatability and measurement validation study. Subjects: Sixteen volunteers and 22 patients scheduled for open-heart aortic valve replacement or septal myectomy. Field Strength/sequence: Prospectively ECG-triggered respiratory-gated free-breathing single-voxel point-resolved spectroscopy (PRESS) sequence at 3 T. Assessment: Myocardial total creatine and triglyceride content were quantified relative to the total water content by fitting the ¹ H-MR spectra. Precision was assessed with measurement repeatability. Accuracy was assessed by validating in vivo ¹ H-MRS measurements against biochemical assays in myocardial tissue from the same subjects. Statistical Tests: Intrasession and intersession repeatability was assessed using Bland-Altman analyses. Agreement between ¹ H-MRS measurements and biochemical assay was tested with regression analyses. Results: The intersession repeatability coefficient for myocardial total creatine content was 41.8% with a mean value of 0.083% ± 0.020% of the total water signal, and 36.7% for myocardial triglyceride content with a mean value of 0.35% ± 0.13% of the total water signal. Ex vivo myocardial total creatine concentrations in tissue samples correlated with the in vivo myocardial total creatine content measured with ¹ H-MRS: n = 22, r = 0.44; P < 0.05. Likewise, ex vivo myocardial triglyceride concentrations correlated with the in vivo myocardial triglyceride content: n = 20, r = 0.50; P < 0.05. Data Conclusion: We validated the use of localized ¹ H-MRS of the human heart at 3 T for quantitative assessments of in vivo myocardial tissue metabolite content by estimating the measurement precision and accuracy. Level of Evidence: 2 TECHNICAL EFFICACY STAGE: 2. (© 2021 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC. on behalf of International Society for Magnetic Resonance in Medicine.)
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معلومات مُعتمدة:	R01 HL144657 United States HL NHLBI NIH HHS; 91617155 Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Netherlands Organisation for Scientific Research; R01 HL144657 United States NH NIH HHS
فهرسة مساهمة:	Keywords: biopsy; magnetic resonance spectroscopy; myectomy; myocardial metabolism; triglycerides; validation
المشرفين على المادة:	0 (Triglycerides) MU72812GK0 (Creatine)
تواريخ الأحداث:	Date Created: 20210211 Date Completed: 20210722 Latest Revision: 20210818
رمز التحديث:	20240628
مُعرف محوري في PubMed:	PMC8277665
DOI:	10.1002/jmri.27531
PMID:	33569824
قاعدة البيانات:	MEDLINE

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تدمد:	1522-2586
DOI:	10.1002/jmri.27531