دورية أكاديمية
أعرض في EDS

Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins.

التفاصيل البيبلوغرافية
العنوان: Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins.
المؤلفون: Kittisopikul M; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL.; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX., Shimi T; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL.; Cell Biology Center and World Research Hub Initiative, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan., Tatli M; Department of Biochemistry, University of Zurich, Zurich, Switzerland., Tran JR; Department of Embryology, Carnegie Institution for Science, Baltimore, MD., Zheng Y; Department of Embryology, Carnegie Institution for Science, Baltimore, MD., Medalia O; Department of Biochemistry, University of Zurich, Zurich, Switzerland., Jaqaman K; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX.; Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX., Adam SA; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL., Goldman RD; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
المصدر: The Journal of cell biology [J Cell Biol] 2021 Apr 05; Vol. 220 (4).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print Cited Medium: Internet ISSN: 1540-8140 (Electronic) Linking ISSN: 00219525 NLM ISO Abbreviation: J Cell Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York : Rockefeller University Press
مواضيع طبية MeSH: Computer Simulation*, Embryo, Mammalian/*metabolism , Fibroblasts/*metabolism , Lamin Type A/*metabolism , Lamin Type B/*metabolism , Nuclear Pore/*metabolism, Animals ; Cell Line ; Embryo, Mammalian/ultrastructure ; Fibroblasts/ultrastructure ; Lamin Type A/genetics ; Lamin Type B/genetics ; Mice ; Mice, Knockout ; Nuclear Pore/genetics ; Nuclear Pore/ultrastructure ; Nuclear Pore Complex Proteins/genetics ; Nuclear Pore Complex Proteins/metabolism
مستخلص: Nuclear lamin isoforms form fibrous meshworks associated with nuclear pore complexes (NPCs). Using datasets prepared from subpixel and segmentation analyses of 3D-structured illumination microscopy images of WT and lamin isoform knockout mouse embryo fibroblasts, we determined with high precision the spatial association of NPCs with specific lamin isoform fibers. These relationships are retained in the enlarged lamin meshworks of Lmna-/- and Lmnb1-/- fibroblast nuclei. Cryo-ET observations reveal that the lamin filaments composing the fibers contact the nucleoplasmic ring of NPCs. Knockdown of the ring-associated nucleoporin ELYS induces NPC clusters that exclude lamin A/C fibers but include LB1 and LB2 fibers. Knockdown of the nucleoporin TPR or NUP153 alters the arrangement of lamin fibers and NPCs. Evidence that the number of NPCs is regulated by specific lamin isoforms is presented. Overall the results demonstrate that lamin isoforms and nucleoporins act together to maintain the normal organization of lamin meshworks and NPCs within the nuclear envelope.
(© 2021 Kittisopikul et al.)
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معلومات مُعتمدة: R01 GM106023 United States GM NIGMS NIH HHS; R35 GM119619 United States GM NIGMS NIH HHS; S10 OD016342 United States OD NIH HHS; T32 CA080621 United States CA NCI NIH HHS
المشرفين على المادة: 0 (Lamin Type A)
0 (Lamin Type B)
0 (Lmna protein, mouse)
0 (Nuclear Pore Complex Proteins)
0 (Nup153 protein, mouse)
تواريخ الأحداث: Date Created: 20210211 Date Completed: 20210921 Latest Revision: 20231213
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7883741
DOI: 10.1083/jcb.202007082
PMID: 33570570
قاعدة البيانات: MEDLINE
الوصف
تدمد:1540-8140
DOI:10.1083/jcb.202007082