دورية أكاديمية
Regulation of Cell Types Within Testicular Organoids.
| العنوان: | Regulation of Cell Types Within Testicular Organoids. |
|---|---|
| المؤلفون: | Lara NLEM; Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada., Sakib S; Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.; Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Dobrinski I; Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.; Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. |
| المصدر: | Endocrinology [Endocrinology] 2021 Apr 01; Vol. 162 (4). |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Los Angeles, Calif. : Association for the Study of Internal Secretions, |
| مواضيع طبية MeSH: | Organoids/*cytology , Testis/*cytology, Animals ; Cell Differentiation ; Humans ; Male ; Organoids/growth & development ; Sertoli Cells/cytology ; Spermatogonia/cytology ; Testis/growth & development |
| مستخلص: | Organoids are 3-dimensional (3D) structures grown in vitro that emulate the cytoarchitecture and functions of true organs. Therefore, testicular organoids arise as an important model for research on male reproductive biology. These organoids can be generated from different sources of testicular cells, but most studies to date have used immature primary cells for this purpose. The complexity of the mammalian testicular cytoarchitecture and regulation poses a challenge for working with testicular organoids, because, ideally, these 3D models should mimic the organization observed in vivo. In this review, we explore the characteristics of the most important cell types present in the testicular organoid models reported to date and discuss how different factors influence the regulation of these cells inside the organoids and their outcomes. Factors such as the developmental or maturational stage of the Sertoli cells, for example, influence organoid generation and structure, which affect the use of these 3D models for research. Spermatogonial stem cells have been a focus recently, especially in regard to male fertility preservation. The regulation of the spermatogonial stem cell niche inside testicular organoids is discussed in the present review, as this research area may be positively affected by recent progress in organoid generation and tissue engineering. Therefore, the testicular organoid approach is a very promising model for male reproductive biology research, but more studies and improvements are necessary to achieve its full potential. (© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| References: | World J Stem Cells. 2020 Oct 26;12(10):1097-1112. (PMID: 33178394) Endocr Rev. 2018 Oct 1;39(5):739-759. (PMID: 29771299) Cell Tissue Res. 2020 Apr;380(1):191-200. (PMID: 31900662) Biomater Res. 2018 Apr 6;22:11. (PMID: 29636985) Tissue Eng Regen Med. 2020 Apr;17(2):223-235. (PMID: 32114677) Biol Reprod. 2017 Mar 1;96(3):720-732. (PMID: 28339648) Reproduction. 2001 Mar;121(3):347-54. (PMID: 11226060) Mol Reprod Dev. 2016 Jun;83(6):470-87. (PMID: 27079813) Cell Mol Life Sci. 2019 Jul;76(14):2681-2695. (PMID: 30980107) Environ Epigenet. 2019 Jul 31;5(3):dvz011. (PMID: 31463083) Hum Reprod Update. 2017 Nov 1;23(6):660-680. (PMID: 28981651) Cell Stem Cell. 2019 Sep 5;25(3):373-387.e9. (PMID: 31303547) Biol Reprod. 2008 Dec;79(6):1210-8. (PMID: 18716291) Science. 2007 Sep 21;317(5845):1722-6. (PMID: 17823316) Nature. 2013 Jul 25;499(7459):481-4. (PMID: 23823721) Andrology. 2020 Jul;8(4):879-891. (PMID: 31823507) Biofabrication. 2020 Jul 09;12(4):045002. (PMID: 32492667) Mech Dev. 2012 Jan-Feb;128(11-12):610-24. (PMID: 22200512) Hum Mol Genet. 2018 Aug 1;27(R2):R99-R107. (PMID: 29796608) Cell Rep. 2012 Sep 27;2(3):440-6. (PMID: 22921399) Reproduction. 2019 Nov;158(5):R169-R187. (PMID: 31247585) Andrology. 2020 Jul;8(4):825-834. (PMID: 31539453) Front Physiol. 2017 Jun 28;8:430. (PMID: 28701961) Nature. 2009 May 14;459(7244):262-5. (PMID: 19329995) Nat Cell Biol. 2016 Mar;18(3):246-54. (PMID: 26911908) Nature. 2001 Nov 1;414(6859):98-104. (PMID: 11689954) Mech Dev. 2002 Apr;113(1):29-39. (PMID: 11900972) Exp Eye Res. 2018 Aug;173:188-193. (PMID: 29772228) Cell. 2016 Jun 16;165(7):1586-1597. (PMID: 27315476) mBio. 2019 Jul 16;10(4):. (PMID: 31311882) Results Probl Cell Differ. 2016;58:1-22. (PMID: 27300173) Nature. 2015 Oct 22;526(7574):564-8. (PMID: 26444236) Sci Adv. 2019 Sep 06;5(9):eaaw2459. (PMID: 31523707) Mol Endocrinol. 2013 Jan;27(1):63-73. (PMID: 23125070) Physiol Rev. 2016 Jan;96(1):1-17. (PMID: 26537427) Int Rev Cell Mol Biol. 2009;278:309-53. (PMID: 19815182) Neuroreport. 2018 May 2;29(7):588-593. (PMID: 29570159) Mol Hum Reprod. 2020 Dec 10;26(12):879-893. (PMID: 33049038) Semin Cell Dev Biol. 2014 Jun;30:2-13. (PMID: 24598768) Ann Biomed Eng. 2017 Jul;45(7):1783-1794. (PMID: 28488216) Int J Mol Sci. 2019 Nov 03;20(21):. (PMID: 31684200) Nature. 2011 Mar 24;471(7339):504-7. (PMID: 21430778) FASEB J. 2009 Dec;23(12):4218-30. (PMID: 19692648) Hum Reprod. 2020 May 1;35(5):1029-1044. (PMID: 32390056) Nature. 2013 Sep 19;501(7467):373-9. (PMID: 23995685) Pharmacol Rev. 2012 Jan;64(1):16-64. (PMID: 22039149) Cell Rep. 2016 Dec 6;17(10):2789-2804. (PMID: 27926879) Development. 2017 Mar 15;144(6):958-962. (PMID: 28292841) Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1829-34. (PMID: 26831079) Cell Rep. 2015 Aug 18;12(7):1107-19. (PMID: 26257171) Development. 2004 Jan;131(2):459-67. (PMID: 14701682) Biol Reprod. 2019 Jun 1;100(6):1648-1660. (PMID: 30927418) Emerg Microbes Infect. 2018 May 9;7(1):82. (PMID: 29739931) FASEB J. 2020 Jul;34(7):9480-9497. (PMID: 32474967) Birth Defects Res. 2018 Feb 15;110(3):190-227. (PMID: 29063715) Biol Reprod. 2012 Jul 01;87(1):13, 1-11. (PMID: 22492971) Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1489-97. (PMID: 26929341) Cell Tissue Res. 2017 Apr;368(1):215-223. (PMID: 27841005) Mol Cell Endocrinol. 2017 Apr 15;445:55-64. (PMID: 27940302) Stem Cell Reports. 2018 Feb 13;10(2):509-523. (PMID: 29398481) Science. 2014 Jul 18;345(6194):1247125. (PMID: 25035496) Nature. 2017 May 4;545(7652):48-53. (PMID: 28445462) J Endocrinol. 2001 Feb;168(2):213-6. (PMID: 11182757) Biofabrication. 2019 Apr 26;11(3):035011. (PMID: 30921781) Hum Reprod Update. 2018 Mar 1;24(2):176-191. (PMID: 29281008) Biomater Sci. 2019 Mar 26;7(4):1422-1436. (PMID: 30666997) Genes Dev. 2013 Nov 15;27(22):2409-26. (PMID: 24240231) Biol Reprod. 2008 Mar;78(3):445-54. (PMID: 18057314) Biol Reprod. 2018 Jul 1;99(1):101-111. (PMID: 29566165) Am J Anat. 1986 Jan;175(1):91-117. (PMID: 3953473) Hum Reprod Update. 2015 May-Jun;21(3):310-28. (PMID: 25724971) Mol Hum Reprod. 2016 Sep;22(9):601-12. (PMID: 27430551) Biofabrication. 2020 Feb 26;12(2):025017. (PMID: 32101533) Environ Epigenet. 2017 Aug 03;3(3):dvx010. (PMID: 29492312) PLoS One. 2018 Feb 12;13(2):e0192884. (PMID: 29432471) Contraception. 2005 Oct;72(4):294-7. (PMID: 16181974) Endocrinology. 1992 Dec;131(6):2928-34. (PMID: 1446630) Nat Rev Genet. 2004 Jul;5(7):509-21. (PMID: 15211353) Stem Cell Reports. 2017 Jan 10;8(1):30-38. (PMID: 28017656) Trends Mol Med. 2020 Mar;26(3):245-249. (PMID: 31982341) Int J Dev Biol. 2013;57(2-4):115-21. (PMID: 23784821) Acta Biomater. 2020 Apr 1;106:124-135. (PMID: 32068138) Nat Commun. 2018 Oct 22;9(1):4379. (PMID: 30348976) Stem Cells. 2011 Aug;29(8):1186-95. (PMID: 21681858) J Hum Genet. 2018 Feb;63(2):165-178. (PMID: 29192237) Mol Hum Reprod. 2018 Feb 1;24(2):55-63. (PMID: 29294090) Int J Mol Sci. 2019 Nov 04;20(21):. (PMID: 31690065) Stem Cell Reports. 2018 Feb 13;10(2):538-552. (PMID: 29398482) Stem Cells. 2009 Apr;27(4):783-95. (PMID: 19350678) Biomaterials. 2017 Jun;130:76-89. (PMID: 28364632) Andrology. 2016 Mar;4(2):189-212. (PMID: 26846984) Environ Epigenet. 2017 Aug 03;3(3):dvx012. (PMID: 29492314) Adv Exp Med Biol. 2012;763:237-59. (PMID: 23397628) Physiol Rev. 2012 Apr;92(2):577-95. (PMID: 22535892) Andrologia. 2000 Jan;32(1):42-5. (PMID: 10702865) Spermatogenesis. 2013 Jan 1;3(1):e24014. (PMID: 23687617) Exp Biol Med (Maywood). 2006 Jan;231(1):1-7. (PMID: 16380639) J Anat. 1964 Jul;98:403-18. (PMID: 14193198) |
| معلومات مُعتمدة: | R01 HD091068 United States HD NICHD NIH HHS; R01 OD016575 United States OD NIH HHS |
| فهرسة مساهمة: | Keywords: in vitro spermatogenesis; morphogenesis; spermatogonial stem cell niche; testicular organoids |
| تواريخ الأحداث: | Date Created: 20210211 Date Completed: 20211018 Latest Revision: 20220212 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7901658 |
| DOI: | 10.1210/endocr/bqab033 |
| PMID: | 33570577 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1945-7170 |
|---|---|
| DOI: | 10.1210/endocr/bqab033 |