دورية أكاديمية
Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes.
| العنوان: | Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes. |
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| المؤلفون: | Temba GS; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Medical Biochemistry and Molecular Biology, Kilimanjaro Christian Medical University College, (KCMUCo), Moshi, Tanzania.; Radboud Centre for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Kullaya V; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Medical Biochemistry and Molecular Biology, Kilimanjaro Christian Medical University College, (KCMUCo), Moshi, Tanzania.; Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical Center, Moshi, Tanzania., Pecht T; Department for Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Mmbaga BT; Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical Center, Moshi, Tanzania., Aschenbrenner AC; Department for Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Ulas T; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and University of Bonn, Bonn, Germany., Kibiki G; Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical Center, Moshi, Tanzania.; East African Health and Research Commission (EAHRC), Bujumbura, Burundi., Lyamuya F; Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical Center, Moshi, Tanzania., Boahen CK; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Centre for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Kumar V; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Centre for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands., Joosten LAB; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Centre for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Schultze JL; Department for Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and University of Bonn, Bonn, Germany., van der Ven AJ; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.; Radboud Centre for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Netea MG; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands. Mihai.Netea@radboudumc.nl.; Radboud Centre for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands. Mihai.Netea@radboudumc.nl.; Department for Immunology and Metabolism, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany. Mihai.Netea@radboudumc.nl., de Mast Q; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands. Quirijn.deMast@radboudumc.nl.; Radboud Centre for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands. Quirijn.deMast@radboudumc.nl. |
| المصدر: | Nature immunology [Nat Immunol] 2021 Mar; Vol. 22 (3), pp. 287-300. Date of Electronic Publication: 2021 Feb 11. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Nature America Inc. c2000- |
| مواضيع طبية MeSH: | Diet, Healthy* , Energy Metabolism*/genetics , Immunity, Innate*/genetics , Rural Health* , Urban Health*, Cytokines/*blood , Inflammation Mediators/*blood, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Cytokines/genetics ; Female ; Humans ; Male ; Metabolome ; Middle Aged ; Nutritional Status ; Nutritive Value ; Risk Reduction Behavior ; Seasons ; Tanzania ; Transcriptome ; Tumor Necrosis Factor-alpha/blood ; Urbanization ; Young Adult |
| مستخلص: | Sub-Saharan Africa currently experiences an unprecedented wave of urbanization, which has important consequences for health and disease patterns. This study aimed to investigate and integrate the immune and metabolic consequences of rural or urban lifestyles and the role of nutritional changes associated with urban living. In a cohort of 323 healthy Tanzanians, urban as compared to rural living was associated with a pro-inflammatory immune phenotype, both at the transcript and protein levels. We identified different food-derived and endogenous circulating metabolites accounting for these differences. Serum from urban dwellers induced reprogramming of innate immune cells with higher tumor necrosis factor production upon microbial re-stimulation in an in vitro model of trained immunity. These data demonstrate important shifts toward an inflammatory phenotype associated with an urban lifestyle and provide new insights into the underlying dietary and metabolic factors, which may affect disease epidemiology in sub-Sahara African countries. |
| التعليقات: | Comment in: Nat Immunol. 2021 Mar;22(3):266-268. (PMID: 33574618) |
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| المشرفين على المادة: | 0 (Biomarkers) 0 (Cytokines) 0 (Inflammation Mediators) 0 (TNF protein, human) 0 (Tumor Necrosis Factor-alpha) |
| تواريخ الأحداث: | Date Created: 20210212 Date Completed: 20210426 Latest Revision: 20230126 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1038/s41590-021-00867-8 |
| PMID: | 33574617 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1529-2916 |
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| DOI: | 10.1038/s41590-021-00867-8 |