دورية أكاديمية
أعرض في EDS

Euryops arabicus Promotes Healing of Excised Wounds in Rat Skin: Emphasis on Its Collagen-Enhancing, Antioxidant, and Anti-Inflammatory Activities.

التفاصيل البيبلوغرافية
العنوان: Euryops arabicus Promotes Healing of Excised Wounds in Rat Skin: Emphasis on Its Collagen-Enhancing, Antioxidant, and Anti-Inflammatory Activities.
المؤلفون: Abdel-Lateff A; Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, P.O. Box 80260, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, P.O. Box 61511, Egypt., Abdel-Naim AB; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, P.O. Box 80260, Saudi Arabia., Alarif WM; Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, Jeddah 21589, P.O. Box 80207, Saudi Arabia., Algandaby MM; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, P.O. Box 80203, Saudi Arabia., Alburae NA; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, P.O. Box 80203, Saudi Arabia., Alghamdi AM; Pharmacy Department, Mental Health Hospital, Taif, P.O. Box 2056, Saudi Arabia., Nasrullah MZ; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, P.O. Box 80260, Saudi Arabia.; Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Mohamed Saeed Tamer Chair for Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Fahmy UA; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
المصدر: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2021 Jan 26; Vol. 2021, pp. 8891445. Date of Electronic Publication: 2021 Jan 26 (Print Publication: 2021).
نوع المنشور: Journal Article; Retracted Publication
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: eCollection Cited Medium: Internet ISSN: 1942-0994 (Electronic) Linking ISSN: 19420994 NLM ISO Abbreviation: Oxid Med Cell Longev Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : New York : Hindawi Pub. Corp.
Original Publication: 2008-2010: Austin, TX : Landes Bioscience
مواضيع طبية MeSH: Wound Healing*/drug effects, Anti-Inflammatory Agents/*pharmacology , Antioxidants/*pharmacology , Asteraceae/*chemistry , Collagen/*metabolism , Skin/*pathology, Animals ; Cell Death/drug effects ; Cell Movement/drug effects ; Cytokines/metabolism ; Gene Expression Regulation/drug effects ; Glutathione/metabolism ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Infant, Newborn ; Inhibitory Concentration 50 ; Keratinocytes/drug effects ; Keratinocytes/pathology ; Male ; Malondialdehyde/metabolism ; Oxidation-Reduction/drug effects ; Plant Extracts/administration & dosage ; Plant Extracts/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Wistar ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism ; Toxicity Tests, Acute ; Transforming Growth Factor beta1/metabolism ; Rats
مستخلص: Euryops arabicus Steud ( E. arabicus ) belongs to the family Asteraceae. It has several uses in folk medicine in the Arabian Peninsula. The current study aimed at evaluating the wound healing properties of the E. arabicus extract in rats. Primarily, E. arabicus successfully accelerated cell migration in vitro and it also showed no signs of dermal toxicity. Topical application of E. arabicus extract (5% or 20%) expedited healing of excised skin in rats. Histological examinations indicated that E. arabicus shortened epithelization period, stimulated fibroblast activity, and increased collagen deposition in wound tissues. The plant extract exerted antioxidant activity as evidenced by inhibition of GSH depletion and MDA accumulation and enhanced mRNA expression of Sod1 in wound tissues collected at the end of the experiment. Further, E. arabicus inhibited the rise of TNF- α and IL-1 β in the skin wound region. The anti-inflammatory was confirmed by the observed down regulation of Ptgs2, Nos2, IL-6, and NF- κ B mRNA expression. In addition, the extract enhanced the expression of TGF- β 1 and HIF-1 α in wounded skin tissues as indicated immunohistochemically. Conclusively, E. arabicus expedites excision wound healing in rats. Collagen-enhancing, anti-inflammatory, and antioxidant properties mediate the observed wound healing activity. These findings might contribute to our understanding of the ethnobotanical use of E. arabicus in wounds.
Competing Interests: The authors have no conflict of interest to declare.
(Copyright © 2021 Ahmed Abdel-Lateff et al.)
التعليقات: Retraction in: Oxid Med Cell Longev. 2023 Oct 4;2023:9840217. (PMID: 37830037)
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المشرفين على المادة: 0 (Anti-Inflammatory Agents)
0 (Antioxidants)
0 (Cytokines)
0 (Hif1a protein, rat)
0 (Hypoxia-Inducible Factor 1, alpha Subunit)
0 (Plant Extracts)
0 (RNA, Messenger)
0 (Transforming Growth Factor beta1)
4Y8F71G49Q (Malondialdehyde)
9007-34-5 (Collagen)
EC 1.15.1.1 (Superoxide Dismutase)
GAN16C9B8O (Glutathione)
تواريخ الأحداث: Date Created: 20210212 Date Completed: 20210518 Latest Revision: 20240330
رمز التحديث: 20240330
مُعرف محوري في PubMed: PMC7857909
DOI: 10.1155/2021/8891445
PMID: 33574987
قاعدة البيانات: MEDLINE
الوصف
تدمد:1942-0994
DOI:10.1155/2021/8891445