دورية أكاديمية
أعرض في EDS

Pathologic complete response with radiation and vismodegib in a patient with advanced basal cell carcinoma: A case report.

التفاصيل البيبلوغرافية
العنوان: Pathologic complete response with radiation and vismodegib in a patient with advanced basal cell carcinoma: A case report.
المؤلفون: Amini A; Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA., Freeman M; Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA., Melstrom L; Department of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA., Margolin KA; Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA., Parekh V; Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA., Abdulla FR; Division of Dermatology, City of Hope National Medical Center, Duarte, CA 91010, USA., Modi B; Division of Dermatology, City of Hope National Medical Center, Duarte, CA 91010, USA.
المصدر: Molecular and clinical oncology [Mol Clin Oncol] 2021 Mar; Vol. 14 (3), pp. 46. Date of Electronic Publication: 2021 Jan 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Spandidos Publications UK Ltd Country of Publication: England NLM ID: 101613422 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2049-9450 (Print) Linking ISSN: 20499450 NLM ISO Abbreviation: Mol Clin Oncol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London, UK : Spandidos Publications UK Ltd
مستخلص: In locally advanced basal cell carcinoma (BCC) patients who are not surgical candidates and where radiation therapy (RT) alone would offer lower control rates, the combination of vismodegib and RT delivered concurrently may potentially improve outcomes compared to single modality treatment. The current study presents a case of very advanced, multifocal BCC who received concurrent vismodegib and RT. The patient initially came in with four large primary areas of disease including the left preauriculum, right shoulder, chest wall and right lateral ankle. All sites achieved a clinical complete response, with a pathologic complete response at the right shoulder. The ankle lesion did not require RT and continues to have a clinical complete response. The findings from our case report support several other cases with similar efficacy when vismodegib and RT are combined.
(Copyright: © Amini et al.)
References: JAMA Dermatol. 2015 Sep;151(9):998-1001. (PMID: 25874733)
Pract Radiat Oncol. 2020 Jan - Feb;10(1):8-20. (PMID: 31831330)
Wound Repair Regen. 2008 Nov-Dec;16(6):768-73. (PMID: 19128247)
N Engl J Med. 2012 Jun 7;366(23):2171-9. (PMID: 22670903)
J Am Acad Dermatol. 2015 Jun;72(6):1021-6.e8. (PMID: 25981002)
Cancer. 1991 Nov 15;68(10):2134-7. (PMID: 1913451)
J Am Acad Dermatol. 2019 Feb;80(2):303-317. (PMID: 29782900)
Int J Mol Sci. 2018 Aug 23;19(9):. (PMID: 30142876)
J Am Acad Dermatol. 2014 Apr;70(4):e88-e89. (PMID: 24629372)
Case Rep Oncol Med. 2015;2015:827608. (PMID: 26504605)
Case Rep Dermatol Med. 2018 Feb 21;2018:2354146. (PMID: 29682362)
Int J Radiat Oncol Biol Phys. 2013 May 1;86(1):143-9. (PMID: 23182391)
فهرسة مساهمة: Keywords: basal cell carcinoma; erivedge; radiation; radiotherapy; vismodegib
تواريخ الأحداث: Date Created: 20210212 Latest Revision: 20210213
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7818096
DOI: 10.3892/mco.2021.2208
PMID: 33575030
قاعدة البيانات: MEDLINE
الوصف
تدمد:2049-9450
DOI:10.3892/mco.2021.2208