دورية أكاديمية
Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study.
| العنوان: | Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study. |
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| المؤلفون: | Ebinger JE; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Botwin GJ; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Albert CM; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Alotaibi M; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, California, USA., Arditi M; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Departments of Pediatrics, Division of Infectious Diseases and Immunology, and Infectious and Immunologic Diseases Research Center (IIDRC), Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA., Berg AH; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Binek A; Advanced Clinical Biosystems Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA., Botting P; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Fert-Bober J; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Figueiredo JC; Cedars-Sinai Cancer and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Grein JD; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Department of Epidemiology, Cedars-Sinai Medical Center, Los Angeles, California, USA., Hasan W; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Biobank & Translational Research Core Laboratory, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Henglin M; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Hussain SK; Department of Public Health Sciences and Comprehensive Cancer Center, University of California, Davis, Davis, California, USA., Jain M; Department of Medicine and Pharmacology, University of California, San Diego, La Jolla, California, USA., Joung S; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Karin M; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, California, USA., Kim EH; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Li D; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Liu Y; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Luong E; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., McGovern DPB; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Merchant A; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Merin N; Department of Internal Medicine, Division of Hematology, Cedars-Sinai Medical Center, Los Angeles, California, USA., Miles PB; Employee Health Services, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Minissian M; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Brawerman Nursing Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Nguyen TT; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Raedschelders K; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Advanced Clinical Biosystems Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA., Rashid MA; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Riera CE; Center for Neural Science and Medicine, Department of Biomedical Sciences, Board of Governors Regenerative Medicine Institute, Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA.; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA., Riggs RV; Chief Medical Officer, Cedars-Sinai Medical Center, Los Angeles, California, USA., Sharma S; La Jolla Institute for Allergy and Immunology, La Jolla, California, USA., Sternbach S; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Sun N; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Tourtellotte WG; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Biobank & Translational Research Core Laboratory, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Van Eyk JE; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Advanced Clinical Biosystems Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Barbra Streisand Women's Heart Center, Cedars-Sinai Medical Center, Los Angeles, California, USA., Sobhani K; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA susan.cheng@cshs.org Jonathan.Braun2@cshs.org Kimia.Sobhani@cshs.org., Braun JG; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA susan.cheng@cshs.org Jonathan.Braun2@cshs.org Kimia.Sobhani@cshs.org., Cheng S; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA susan.cheng@cshs.org Jonathan.Braun2@cshs.org Kimia.Sobhani@cshs.org.; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Barbra Streisand Women's Heart Center, Cedars-Sinai Medical Center, Los Angeles, California, USA. |
| المصدر: | BMJ open [BMJ Open] 2021 Feb 12; Vol. 11 (2), pp. e043584. Date of Electronic Publication: 2021 Feb 12. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BMJ Publishing Group Ltd, 2011- |
| مواضيع طبية MeSH: | Health Personnel* , Seroepidemiologic Studies*, Antibodies, Viral/*blood , COVID-19/*diagnosis, Adult ; Bayes Theorem ; COVID-19/immunology ; COVID-19 Serological Testing ; Cohort Studies ; Cross-Sectional Studies ; Female ; Humans ; Los Angeles/epidemiology ; Male ; Middle Aged ; SARS-CoV-2/immunology |
| مستخلص: | Objective: We sought to determine the extent of SARS-CoV-2 seroprevalence and the factors associated with seroprevalence across a diverse cohort of healthcare workers. Design: Observational cohort study of healthcare workers, including SARS-CoV-2 serology testing and participant questionnaires. Settings: A multisite healthcare delivery system located in Los Angeles County. Participants: A diverse and unselected population of adults (n=6062) employed in a multisite healthcare delivery system located in Los Angeles County, including individuals with direct patient contact and others with non-patient-oriented work functions. Main Outcomes: Using Bayesian and multivariate analyses, we estimated seroprevalence and factors associated with seropositivity and antibody levels, including pre-existing demographic and clinical characteristics; potential COVID-19 illness-related exposures; and symptoms consistent with COVID-19 infection. Results: We observed a seroprevalence rate of 4.1%, with anosmia as the most prominently associated self-reported symptom (OR 11.04, p<0.001) in addition to fever (OR 2.02, p=0.002) and myalgias (OR 1.65, p=0.035). After adjusting for potential confounders, seroprevalence was also associated with Hispanic ethnicity (OR 1.98, p=0.001) and African-American race (OR 2.02, p=0.027) as well as contact with a COVID-19-diagnosed individual in the household (OR 5.73, p<0.001) or clinical work setting (OR 1.76, p=0.002). Importantly, African-American race and Hispanic ethnicity were associated with antibody positivity even after adjusting for personal COVID-19 diagnosis status, suggesting the contribution of unmeasured structural or societal factors. Conclusion and Relevance: The demographic factors associated with SARS-CoV-2 seroprevalence among our healthcare workers underscore the importance of exposure sources beyond the workplace. The size and diversity of our study population, combined with robust survey and modelling techniques, provide a vibrant picture of the demographic factors, exposures and symptoms that can identify individuals with susceptibility as well as potential to mount an immune response to COVID-19. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.) |
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| معلومات مُعتمدة: | K23 HL153888 United States HL NHLBI NIH HHS; U54 CA260591 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: COVID-19; infectious diseases; public health |
| المشرفين على المادة: | 0 (Antibodies, Viral) |
| تواريخ الأحداث: | Date Created: 20210213 Date Completed: 20210225 Latest Revision: 20240330 |
| رمز التحديث: | 20240330 |
| مُعرف محوري في PubMed: | PMC7883610 |
| DOI: | 10.1136/bmjopen-2020-043584 |
| PMID: | 33579769 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2044-6055 |
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| DOI: | 10.1136/bmjopen-2020-043584 |