دورية أكاديمية
أعرض في EDS

The effects of high fat diet, bone healing, and BMP-2 treatment on endothelial cell growth and function.

التفاصيل البيبلوغرافية
العنوان: The effects of high fat diet, bone healing, and BMP-2 treatment on endothelial cell growth and function.
المؤلفون: Bhatti FUR; Department of Orthopaedic Surgery, Indiana University School of Medicine, IN, USA; Richard L. Roudebush VA Medical Center, IN, USA., Dadwal UC; Department of Orthopaedic Surgery, Indiana University School of Medicine, IN, USA; Richard L. Roudebush VA Medical Center, IN, USA., Valuch CR; Department of Biology, Indiana University Purdue University Indianapolis, IN, USA., Tewari NP; Department of Orthopaedic Surgery, Indiana University School of Medicine, IN, USA., Awosanya OD; Department of Orthopaedic Surgery, Indiana University School of Medicine, IN, USA., de Andrade Staut C; Department of Orthopaedic Surgery, Indiana University School of Medicine, IN, USA., Sun S; Department of Orthopaedic Surgery, Indiana University School of Medicine, IN, USA., Mendenhall SK; Department of Orthopaedic Surgery, Indiana University School of Medicine, IN, USA., Perugini AJ 3rd; Department of Orthopaedic Surgery, Indiana University School of Medicine, IN, USA., Nagaraj RU; Department of Orthopaedic Surgery, Indiana University School of Medicine, IN, USA., Battina HL; Department of Orthopaedic Surgery, Indiana University School of Medicine, IN, USA., Nazzal MK; Department of Orthopaedic Surgery, Indiana University School of Medicine, IN, USA., Blosser RJ; Department of Orthopaedic Surgery, Indiana University School of Medicine, IN, USA; Richard L. Roudebush VA Medical Center, IN, USA., Maupin KA; Department of Orthopaedic Surgery, Indiana University School of Medicine, IN, USA., Childress PJ; Department of Orthopaedic Surgery, Indiana University School of Medicine, IN, USA; Richard L. Roudebush VA Medical Center, IN, USA., Li J; Department of Biology, Indiana University Purdue University Indianapolis, IN, USA., Kacena MA; Department of Orthopaedic Surgery, Indiana University School of Medicine, IN, USA; Richard L. Roudebush VA Medical Center, IN, USA. Electronic address: mkacena@iupui.edu.
المصدر: Bone [Bone] 2021 May; Vol. 146, pp. 115883. Date of Electronic Publication: 2021 Feb 11.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2763 (Electronic) Linking ISSN: 18732763 NLM ISO Abbreviation: Bone Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Elsevier Science
Original Publication: Elmsford, NY : Pergamon Press, c1985-
مواضيع طبية MeSH: Diabetes Mellitus, Experimental* , Femoral Fractures*, Animals ; Cell Proliferation ; Diet, High-Fat/adverse effects ; Endothelial Cells ; Mice
مستخلص: Angiogenesis is a vital process during the regeneration of bone tissue. The aim of this study was to investigate angiogenesis at the fracture site as well as at distal locations from obesity-induced type 2 diabetic mice that were treated with bone morphogenetic protein-2 (BMP-2, local administration at the time of surgery) to heal a femoral critical sized defect (CSD) or saline as a control. Mice were fed a high fat diet (HFD) to induce a type 2 diabetic-like phenotype while low fat diet (LFD) animals served as controls. Endothelial cells (ECs) were isolated from the lungs (LECs) and bone marrow (BMECs) 3 weeks post-surgery, and the fractured femurs were also examined. Our studies demonstrate that local administration of BMP-2 at the fracture site in a CSD model results in complete bone healing within 3 weeks for all HFD mice and 66.7% of LFD mice, whereas those treated with saline remain unhealed. At the fracture site, vessel parameters and adipocyte numbers were significantly increased in BMP-2 treated femurs, irrespective of diet. At distal sites, LEC and BMEC proliferation was not altered by diet or BMP-2 treatment. HFD increased the tube formation ability of both LECs and BMECs. Interestingly, BMP-2 treatment at the time of surgery reduced tube formation in LECs and humeri BMECs. However, migration of BMECs from HFD mice treated with BMP-2 was increased compared to BMECs from HFD mice treated with saline. BMP-2 treatment significantly increased the expression of CD31, FLT-1, and ANGPT2 in LECs and BMECs in LFD mice, but reduced the expression of these same genes in HFD mice. To date, this is the first study that depicts the systemic influence of fracture surgery and local BMP-2 treatment on the proliferation and angiogenic potential of ECs derived from the bone marrow and lungs.
(Published by Elsevier Inc.)
References: EMBO J. 2013 Oct 2;32(19):2535-47. (PMID: 24022369)
Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1952-9. (PMID: 23744993)
Nature. 2014 Mar 20;507(7492):323-328. (PMID: 24646994)
Front Pharmacol. 2013 Oct 01;4:125. (PMID: 24101902)
Cancer Res. 1995 Dec 1;55(23):5687-92. (PMID: 7585655)
Diabetologia. 2016 Aug;59(8):1616-20. (PMID: 27207083)
J Orthop Res. 2018 Mar;36(3):945-953. (PMID: 28833572)
Am J Epidemiol. 2007 Sep 1;166(5):495-505. (PMID: 17575306)
J Dent Res. 2007 Oct;86(10):937-50. (PMID: 17890669)
J Biomed Mater Res A. 2012 Sep;100(9):2382-91. (PMID: 22528545)
Aging Clin Exp Res. 2009 Feb;21(1):27-32. (PMID: 19225266)
BMC Bioinformatics. 2017 Nov 29;18(1):529. (PMID: 29187165)
Curr Osteoporos Rep. 2015 Oct;13(5):327-35. (PMID: 26254939)
PLoS One. 2011;6(12):e28639. (PMID: 22216102)
JAMA. 2011 Jun 1;305(21):2184-92. (PMID: 21632482)
J Bone Miner Res. 2012 Feb;27(2):309-18. (PMID: 21987408)
Methods Mol Biol. 2014;1135:393-402. (PMID: 24510881)
Foot Ankle Int. 2009 Nov;30(11):1042-7. (PMID: 19912712)
Front Physiol. 2019 Feb 12;10:101. (PMID: 30809157)
J Orthop Res. 2018 Jan;36(1):129-137. (PMID: 28681967)
Cold Spring Harb Perspect Med. 2012 Sep 01;2(9):a006550. (PMID: 22951441)
J Cell Biol. 2003 Jun 23;161(6):1163-77. (PMID: 12810700)
Calcif Tissue Int. 2017 May;100(5):528-535. (PMID: 28280846)
Cell Physiol Biochem. 2014;34(4):1339-50. (PMID: 25301360)
Bone Rep. 2020 Feb 05;12:100250. (PMID: 32090156)
Science. 1997 Jul 4;277(5322):55-60. (PMID: 9204896)
Diabetes Care. 2006 Jul;29(7):1573-8. (PMID: 16801581)
Cancer Res. 2001 Feb 1;61(3):1207-13. (PMID: 11221852)
J Trauma. 2010 Mar;68(3):629-32. (PMID: 19996801)
Osteoporos Int. 2014 Jul;25(7):1969-73. (PMID: 24718377)
Ann Vasc Surg. 1992 Nov;6(6):503-10. (PMID: 1463663)
Tissue Eng Part A. 2012 Oct;18(19-20):2052-62. (PMID: 22563713)
Nat Rev Endocrinol. 2017 Apr;13(4):208-219. (PMID: 27658727)
Calcif Tissue Int. 2011 Nov;89(5):347-57. (PMID: 21882012)
J Clin Invest. 2011 Jun;121(6):2278-89. (PMID: 21606590)
Tissue Eng Part A. 2014 Aug;20(15-16):2077-87. (PMID: 24350567)
N Engl J Med. 1980 Sep 4;303(10):567-70. (PMID: 7402221)
J Bone Miner Res. 2012 Feb;27(2):301-8. (PMID: 22052532)
Tissue Eng Part A. 2008 Aug;14(8):1285-94. (PMID: 18593269)
PLoS One. 2015 Oct 14;10(10):e0140502. (PMID: 26465321)
Cardiovasc Diabetol. 2010 Dec 08;9:86. (PMID: 21143859)
Cardiovasc Diabetol. 2017 Sep 29;16(1):121. (PMID: 28962618)
Nat Methods. 2012 Jun 28;9(7):676-82. (PMID: 22743772)
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Jan;103(1):38-42. (PMID: 17178492)
J Biomed Sci Eng. 2013 Aug;6(8A):32-52. (PMID: 26819651)
Biol Res. 2013;46(4):421-9. (PMID: 24510144)
Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11709-14. (PMID: 9751730)
Am J Pathol. 1997 Sep;151(3):671-7. (PMID: 9284815)
Diabetes Care. 2002 Oct;25(10):1749-54. (PMID: 12351472)
Mech Dev. 2001 Feb;100(2):245-50. (PMID: 11165481)
J Biomed Mater Res A. 2016 Oct;104(10):2441-55. (PMID: 27176560)
J Biol Chem. 1997 Sep 19;272(38):23659-67. (PMID: 9295307)
FASEB J. 2017 Nov;31(11):4720-4733. (PMID: 28733457)
Mar Drugs. 2018 Dec 18;16(12):. (PMID: 30567329)
Plast Reconstr Surg. 2000 Aug;106(2):360-71; discussion 372. (PMID: 10946935)
J Vis Exp. 2018 Jan 7;(131):. (PMID: 29364280)
Trends Cardiovasc Med. 2000 Jul;10(5):223-8. (PMID: 11282299)
Injury. 2016 Jul;47(7):1435-44. (PMID: 27156834)
PLoS One. 2014 Jun 09;9(6):e99656. (PMID: 24911161)
Sci Rep. 2019 Feb 6;9(1):1458. (PMID: 30728372)
Curr Opin Endocrinol Diabetes Obes. 2009 Dec;16(6):435-45. (PMID: 19779334)
Arch Bone Jt Surg. 2019 Nov;7(6):498-505. (PMID: 31970254)
Bone. 2007 Jun;40(6):1602-9. (PMID: 17433804)
Clin Orthop Relat Res. 1988 Jul;(232):210-6. (PMID: 3289812)
iScience. 2018 Jun 29;4:20-35. (PMID: 30240741)
Tissue Eng Part A. 2019 Dec;25(23-24):1623-1634. (PMID: 30973074)
Circ Res. 2007 Mar 30;100(6):782-94. (PMID: 17395884)
Biomaterials. 2007 Jan;28(3):459-67. (PMID: 16996588)
Arch Biochem Biophys. 2014 Nov 1;561:109-17. (PMID: 25034215)
Mol Carcinog. 2012 Nov;51(11):869-80. (PMID: 21919080)
Ther Adv Musculoskelet Dis. 2017 Mar;9(3):67-74. (PMID: 28344668)
Acta Orthop. 2012 Dec;83(6):653-60. (PMID: 23140093)
BMC Biol. 2012 Apr 30;10:37. (PMID: 22540193)
Blood. 2011 May 26;117(21):5762-71. (PMID: 21460247)
Life Sci Space Res (Amst). 2018 Feb;16:52-62. (PMID: 29475520)
Angiogenesis. 2006;9(4):225-30; discussion 231. (PMID: 17109193)
Diabetes. 2016 Jul;65(7):1757-66. (PMID: 27329951)
Curr Med Res Opin. 2009 May;25(5):1057-72. (PMID: 19292601)
Curr Opin Endocrinol Diabetes Obes. 2007 Dec;14(6):429-35. (PMID: 17982347)
Development. 2011 May;138(10):2111-20. (PMID: 21521739)
Am J Pathol. 1999 Sep;155(3):887-95. (PMID: 10487846)
Bone. 2014 Feb;59:189-98. (PMID: 24291420)
J Cell Biochem. 2003 Apr 1;88(5):873-84. (PMID: 12616527)
Methods Mol Biol. 2012;821:421-33. (PMID: 22125082)
Mol Cell Biol. 2009 Apr;29(8):2011-22. (PMID: 19223473)
Circ Res. 2009 Sep 11;105(6):575-84. (PMID: 19661459)
Front Endocrinol (Lausanne). 2013 Aug 26;4:106. (PMID: 23986744)
Development. 2009 Apr;136(8):1263-72. (PMID: 19261698)
J Bone Oncol. 2018 Sep 08;13:1-10. (PMID: 30245970)
Osteoporos Int. 2007 Apr;18(4):427-44. (PMID: 17068657)
Exp Hematol. 2019 Nov;79:3-15.e4. (PMID: 31669153)
Mol Biol Cell. 1997 Jul;8(7):1329-41. (PMID: 9243511)
Osteoporos Int. 2016 Jan;27(1):49-56. (PMID: 26138582)
Front Bioeng Biotechnol. 2017 Nov 03;5:68. (PMID: 29164110)
Br J Pharmacol. 2012 Jun;166(3):877-94. (PMID: 22352879)
Cold Spring Harb Perspect Med. 2013 Jan 01;3(1):a006569. (PMID: 23085847)
J Bone Joint Surg Am. 2019 Aug 7;101(15):1399-1410. (PMID: 31393433)
Nature. 2014 Mar 20;507(7492):376-380. (PMID: 24647000)
Eur J Orthop Surg Traumatol. 2018 Oct;28(7):1429-1436. (PMID: 29633016)
J Immunol. 1997 Apr 1;158(7):3408-16. (PMID: 9120301)
HSS J. 2010 Feb;6(1):85-94. (PMID: 19763695)
J Bone Miner Res. 2017 Jul;32(7):1442-1454. (PMID: 28300321)
Injury. 2011 Jun;42(6):556-61. (PMID: 21489534)
معلومات مُعتمدة: R01 AG060621 United States AG NIA NIH HHS; T32 HL007910 United States HL NHLBI NIH HHS; P30 DK097512 United States DK NIDDK NIH HHS; U54 DK106846 United States DK NIDDK NIH HHS; I01 BX003751 United States BX BLRD VA; T32 DK007519 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Angiogenesis; Bone; Bone healing; Bone morphogenetic protein; Bone regeneration; Endothelial cells; Fracture healing; High fat diet; Type 2 diabetes
تواريخ الأحداث: Date Created: 20210213 Date Completed: 20210708 Latest Revision: 20240407
رمز التحديث: 20240407
مُعرف محوري في PubMed: PMC8009863
DOI: 10.1016/j.bone.2021.115883
PMID: 33581374
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2763
DOI:10.1016/j.bone.2021.115883