دورية أكاديمية
أعرض في EDS

Thromboinflammatory Biomarkers in COVID-19: Systematic Review and Meta-analysis of 17,052 Patients.

التفاصيل البيبلوغرافية
العنوان: Thromboinflammatory Biomarkers in COVID-19: Systematic Review and Meta-analysis of 17,052 Patients.
المؤلفون: Chaudhary R; Division of Hospital Internal Medicine, Mayo Clinic, Rochester, MN.; Division of Cardiology, University of Pittsburgh Medical Center Heart and Vascular Institute, Pittsburgh, PA., Garg J; Division of Cardiology, Medical College of Wisconsin, Milwaukee., Houghton DE; Division of Vascular Medicine, Mayo Clinic, Rochester, MN., Murad MH; Evidence-based Practice Center, Mayo Clinic, Rochester, MN., Kondur A; Division of Cardiology, Garden City Hospital, Garden City, MI., Chaudhary R; Deakin University, Melbourne, Australia., Wysokinski WE; Division of Vascular Medicine, Mayo Clinic, Rochester, MN., McBane RD 2nd; Division of Vascular Medicine, Mayo Clinic, Rochester, MN.
المصدر: Mayo Clinic proceedings. Innovations, quality & outcomes [Mayo Clin Proc Innov Qual Outcomes] 2021 Apr; Vol. 5 (2), pp. 388-402. Date of Electronic Publication: 2021 Feb 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc Country of Publication: Netherlands NLM ID: 101728275 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2542-4548 (Electronic) Linking ISSN: 25424548 NLM ISO Abbreviation: Mayo Clin Proc Innov Qual Outcomes Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Netherlands] : Elsevier Inc., [2017]-
مستخلص: Objective: To evaluate differences in thromboinflammatory biomarkers between patients with severe coronavirus disease 2019 (COVID-19) infection/death and mild infection.
Patients and Methods: MEDLINE, Cochrane Central Register of Controlled Trials, EMBASE, EBSCO, Web of Science, and CINAHL databases were searched for studies comparing thromboinflammatory biomarkers in COVID-19 among patients with severe COVID-19 disease or death (severe/nonsurvivors) and those with nonsevere disease or survivors (nonsevere/survivors) from January 1, 2020, through July 11, 2020. Inclusion criteria were (1) hospitalized patients 18 years or older comparing severe/nonsurvivors vs nonsevere/survivors and (2) biomarkers of inflammation and/or thrombosis. A random-effects model was used to estimate the weighted mean difference (WMD) between the 2 groups of COVID-19 severity.
Results: We included 75 studies with 17,052 patients. The severe/nonsurvivor group was older, had a greater proportion of men, and had a higher prevalence of hypertension, diabetes, cardiac or cerebrovascular disease, chronic kidney disease, malignancy, and chronic obstructive pulmonary disease. Thromboinflammatory biomarkers were significantly higher in patients with severe disease, including D-dimer (WMD, 0.60; 95% CI, 0.49 to 0.71; I 2 =83.85%), fibrinogen (WMD, 0.42; 95% CI, 0.18 to 0.67; I 2 =61.88%; P <.001), C-reactive protein (CRP) (WMD, 35.74; 95% CI, 30.16 to 41.31; I 2 =85.27%), high-sensitivity CRP (WMD, 62.68; 95% CI, 45.27 to 80.09; I 2 =0%), interleukin 6 (WMD, 22.81; 95% CI, 17.90 to 27.72; I 2 =90.42%), and ferritin (WMD, 506.15; 95% CI, 356.24 to 656.06; I 2 =52.02%). Moderate to significant heterogeneity was observed for all parameters ( I 2 > 25%). Subanalysis based on disease severity, mortality, and geographic region of the studies revealed similar inferences.
Conclusion: Thromboinflammatory biomarkers (D-dimer, fibrinogen, CRP, high-sensitivity CRP, ferritin, and interleukin 6) and marker of end-organ damage (high-sensitivity troponin I) are associated with increased severity and mortality in COVID-19 infection.
(© 2021 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc.)
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فهرسة مساهمة: Keywords: COVID-19, coronavirus disease 2019; CRP, C-reactive protein; ECMO, extracorporeal membrane oxygenation; IL-6, interleukin 6; LDH, lactate dehydrogenase; OR, odds ratio; WMD, weighted mean difference; hs, high-sensitivity
تواريخ الأحداث: Date Created: 20210215 Latest Revision: 20240828
رمز التحديث: 20240828
مُعرف محوري في PubMed: PMC7869679
DOI: 10.1016/j.mayocpiqo.2021.01.009
PMID: 33585800
قاعدة البيانات: MEDLINE
الوصف
تدمد:2542-4548
DOI:10.1016/j.mayocpiqo.2021.01.009