دورية أكاديمية
Comparative Efficacy of Various Pharmacological Interventions in the Treatment of Functional Dyspepsia: A Network Meta-Analysis.
العنوان: | Comparative Efficacy of Various Pharmacological Interventions in the Treatment of Functional Dyspepsia: A Network Meta-Analysis. |
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المؤلفون: | Liang L; Department of Psychiatry, Renmin Hospital of Wuhan University, Hubei Zhang Road (Formerly Ziyang Road), Wuchang District No. 99, Jiefang Road 238, Wuhan, Hubei Province, China., Yu J; Department of General Surgery, Renmin Hospital of Wuhan University, Hubei Zhang Road (formerly Ziyang Road), Wuchang District No. 99, Jiefang Road 238, Wuhan, Hubei Province, China., Xiao L; Department of Psychiatry, Renmin Hospital of Wuhan University, Hubei Zhang Road (Formerly Ziyang Road), Wuchang District No. 99, Jiefang Road 238, Wuhan, Hubei Province, China., Wang G; Department of Psychiatry, Renmin Hospital of Wuhan University, Hubei Zhang Road (Formerly Ziyang Road), Wuchang District No. 99, Jiefang Road 238, Wuhan, Hubei Province, China. wgh6402@163.com. |
المصدر: | Digestive diseases and sciences [Dig Dis Sci] 2022 Jan; Vol. 67 (1), pp. 187-207. Date of Electronic Publication: 2021 Feb 15. |
نوع المنشور: | Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 7902782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2568 (Electronic) Linking ISSN: 01632116 NLM ISO Abbreviation: Dig Dis Sci Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2005- : New York, NY : Springer Science + Business Media Original Publication: New York, Plenum Pub. Corp. |
مواضيع طبية MeSH: | Dyspepsia/*drug therapy , Gastrointestinal Agents/*pharmacology, Cisapride/pharmacology ; Comparative Effectiveness Research ; Humans ; Network Meta-Analysis ; Sulpiride/analogs & derivatives ; Sulpiride/pharmacology |
مستخلص: | Background and Aim: Patients with functional dyspepsia often select different pharmacological treatments. We aimed to compare and rank the efficacy of different pharmacological interventions in treating functional dyspepsia. Methods: We searched EMBASE, PubMed, Cochrane, Web of Science and MEDLINE from the date of database inception to March 28, 2019. A random-effects model was selected to conduct traditional meta-analysis to directly examine the efficacy of different pharmacological interventions. The consistency model was selected to conduct a network meta-analysis to evaluate the relative effects and rank probability of different pharmacological interventions. Results: We included 58 trials (15,629 participants and 21 pharmacological treatments). Network meta-analysis showed that cisapride, domperidone, itopride, and levosulpiride were better than placebo, especially in short term (< 4 weeks). And levosulpiride was significantly more effective than 15 other drugs and placebo (ORs ranging between 0.05 and 0.15). Cisapride was significantly more effective than lansoprazole (OR 0.30, 95% CrI 0.09-0.99) and tegaserod (OR 0.26, 95% CrI 0.07-0.98). The rank probability showed that levosulpiride was most likely to be rank 1 (77%), cinitapride rank 2 (17%), and cisapride rank 3 (23%). Conclusions: Our study confirmed the effectiveness of several pharmacological treatments for ameliorating functional dyspepsia. Furthermore, levosulpiride relatively ranked the best in managing FD. Physicians should be encouraged to apply promising pharmacological interventions (e.g., levosulpiride and cisapride). However, the results should be interpreted with caution due to small study effects. (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.) |
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فهرسة مساهمة: | Keywords: Efficacy; Functional dyspepsia; Levosulpiride; Network meta-analysis; Pharmacological interventions |
المشرفين على المادة: | 0 (Gastrointestinal Agents) 7MNE9M8287 (Sulpiride) JTG7R315LK (levosulpiride) UVL329170W (Cisapride) |
تواريخ الأحداث: | Date Created: 20210216 Date Completed: 20220216 Latest Revision: 20220531 |
رمز التحديث: | 20221213 |
DOI: | 10.1007/s10620-021-06846-1 |
PMID: | 33590403 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-2568 |
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DOI: | 10.1007/s10620-021-06846-1 |