دورية أكاديمية
Safety indicators of a novel multi supplement based on guarana, selenium, and L-carnitine: Evidence from human and red earthworm immune cells.
العنوان: | Safety indicators of a novel multi supplement based on guarana, selenium, and L-carnitine: Evidence from human and red earthworm immune cells. |
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المؤلفون: | Teixeira CF; Postgraduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., da Cruz IBM; Postgraduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil; Postgraduate Program in Gerontology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., Ribeiro EE; Third Age Open University/Amazonas State University, Manaus, 69065-001, Brazil., Pillar DM; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., Turra BO; Postgraduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., Praia RS; Third Age Open University/Amazonas State University, Manaus, 69065-001, Brazil., Barbisan F; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil; Postgraduate Program in Gerontology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., Alves AO; Postgraduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., Sato DK; Pontifical Catholic University of Rio Grande Do Sul - PUCRS, Porto Alegre, 90619-900, Brazil., Assmann CE; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil; Postgraduate Program in Biological Sciences: Biochemistry Toxicology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., Palma TV; Postgraduate Program in Biological Sciences: Biochemistry Toxicology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., Barcelos RP; University of Passo Fundo, Passo Fundo, 99052-900, Brazil., Barbosa IM; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., Azzolin VF; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil; Postgraduate Program in Gerontology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil. Electronic address: azzolinveronica@hotmail.com. |
المصدر: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2021 Apr; Vol. 150, pp. 112066. Date of Electronic Publication: 2021 Feb 15. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Exeter : Elsevier Science Ltd Original Publication: Oxford ; New York : Pergamon Press, c1982- |
مواضيع طبية MeSH: | Paullinia*, Carnitine/*pharmacology , Eimeria/*drug effects , Selenium/*pharmacology, Carnitine/chemistry ; Cell Cycle ; Cell Line ; Cell Survival/drug effects ; DNA Damage/drug effects ; Humans ; Lipid Peroxidation ; Microglia ; Oxidation-Reduction ; Selenium/chemistry |
مستخلص: | Neurodegenerative diseases are associated with chronic inflammatory states. There is evidence to support the design of novel supplements based on guarana (G) (Paullinia cupana), selenium (S), and L-carnitine (C), the use of which, potentially attenuates neuro oxi-inflammatory conditions. Therefore, this study analyzed the cytotoxic and redox effects of GSC on human leucocytes, the inflammatory activation of microglia BV-2 cells, and effect on mortality, oxidative metabolism, and the immune modulation of red earthworms (Eisenia fetida). The GSC concentrations tested in cell culture were in the range of 0.04-2.1 mg/mL. All the GSC-supplemented samples tested, reverted H (Copyright © 2021 Elsevier Ltd. All rights reserved.) |
فهرسة مساهمة: | Keywords: Anti-inflammatory; Antioxidant; Guarana; L-carnitine; Selenium |
المشرفين على المادة: | H6241UJ22B (Selenium) S7UI8SM58A (Carnitine) |
تواريخ الأحداث: | Date Created: 20210217 Date Completed: 20210730 Latest Revision: 20210730 |
رمز التحديث: | 20221213 |
DOI: | 10.1016/j.fct.2021.112066 |
PMID: | 33596454 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1873-6351 |
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DOI: | 10.1016/j.fct.2021.112066 |