دورية أكاديمية
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Safety indicators of a novel multi supplement based on guarana, selenium, and L-carnitine: Evidence from human and red earthworm immune cells.

التفاصيل البيبلوغرافية
العنوان: Safety indicators of a novel multi supplement based on guarana, selenium, and L-carnitine: Evidence from human and red earthworm immune cells.
المؤلفون: Teixeira CF; Postgraduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., da Cruz IBM; Postgraduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil; Postgraduate Program in Gerontology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., Ribeiro EE; Third Age Open University/Amazonas State University, Manaus, 69065-001, Brazil., Pillar DM; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., Turra BO; Postgraduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., Praia RS; Third Age Open University/Amazonas State University, Manaus, 69065-001, Brazil., Barbisan F; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil; Postgraduate Program in Gerontology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., Alves AO; Postgraduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., Sato DK; Pontifical Catholic University of Rio Grande Do Sul - PUCRS, Porto Alegre, 90619-900, Brazil., Assmann CE; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil; Postgraduate Program in Biological Sciences: Biochemistry Toxicology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., Palma TV; Postgraduate Program in Biological Sciences: Biochemistry Toxicology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., Barcelos RP; University of Passo Fundo, Passo Fundo, 99052-900, Brazil., Barbosa IM; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil., Azzolin VF; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil; Postgraduate Program in Gerontology, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil. Electronic address: azzolinveronica@hotmail.com.
المصدر: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2021 Apr; Vol. 150, pp. 112066. Date of Electronic Publication: 2021 Feb 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE
أسماء مطبوعة: Publication: Exeter : Elsevier Science Ltd
Original Publication: Oxford ; New York : Pergamon Press, c1982-
مواضيع طبية MeSH: Paullinia*, Carnitine/*pharmacology , Eimeria/*drug effects , Selenium/*pharmacology, Carnitine/chemistry ; Cell Cycle ; Cell Line ; Cell Survival/drug effects ; DNA Damage/drug effects ; Humans ; Lipid Peroxidation ; Microglia ; Oxidation-Reduction ; Selenium/chemistry
مستخلص: Neurodegenerative diseases are associated with chronic inflammatory states. There is evidence to support the design of novel supplements based on guarana (G) (Paullinia cupana), selenium (S), and L-carnitine (C), the use of which, potentially attenuates neuro oxi-inflammatory conditions. Therefore, this study analyzed the cytotoxic and redox effects of GSC on human leucocytes, the inflammatory activation of microglia BV-2 cells, and effect on mortality, oxidative metabolism, and the immune modulation of red earthworms (Eisenia fetida). The GSC concentrations tested in cell culture were in the range of 0.04-2.1 mg/mL. All the GSC-supplemented samples tested, reverted H 2 O 2 oxidation in DNA molecules, suggesting its genoprotective potential. GSC did not induce mortality in leucocyte cultures. On the contrary, a reduction in the levels of oxidation of lipids, proteins, and cell apoptosis was observed, via downregulation of caspase 3 and 8 genes. GSC showed a dual effect on microglia, decreasing the cellular proliferation at lower concentrations (<0.24 mg/mL) and increasing the cellular proliferation mainly at concentrations > 1.0 mg/mL. GSC did not have a toxic effect on red earthworms, but induced an increase in amoebocyte cells and in brown body formation, indicating immune response activation. The results suggest that GSC could be safe for human consumption.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Anti-inflammatory; Antioxidant; Guarana; L-carnitine; Selenium
المشرفين على المادة: H6241UJ22B (Selenium)
S7UI8SM58A (Carnitine)
تواريخ الأحداث: Date Created: 20210217 Date Completed: 20210730 Latest Revision: 20210730
رمز التحديث: 20221213
DOI: 10.1016/j.fct.2021.112066
PMID: 33596454
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-6351
DOI:10.1016/j.fct.2021.112066