دورية أكاديمية
The Use of the Oxygenated AirdriveTM Machine Perfusion System in Kidney Graft Preservation: A Clinical Pilot Study.
| العنوان: | The Use of the Oxygenated AirdriveTM Machine Perfusion System in Kidney Graft Preservation: A Clinical Pilot Study. |
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| المؤلفون: | Houtzager JHE; Department of Surgery, Amsterdam University Medical Center, Location Academic Medical Center, Amsterdam, The Netherlands, j.h.houtzager@amsterdamumc.nl., Hemelrijk SD; Department of Surgery, Amsterdam University Medical Center, Location Academic Medical Center, Amsterdam, The Netherlands.; Department of Anaesthesiology, Amsterdam University Medical Center, Location Academic Medical Center, Amsterdam, The Netherlands., Post ICJH; Department of Vascular Surgery, Martini Hospital, Groningen, The Netherlands., Idu MM; Department of Surgery, Amsterdam University Medical Center, Location Academic Medical Center, Amsterdam, The Netherlands., Bemelman FJ; Department of Nephrology, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, The Netherlands., van Gulik TM; Department of Surgery, Amsterdam University Medical Center, Location Academic Medical Center, Amsterdam, The Netherlands. |
| المصدر: | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes [Eur Surg Res] 2020; Vol. 61 (6), pp. 153-162. Date of Electronic Publication: 2021 Feb 18. |
| نوع المنشور: | Clinical Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 0174752 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1421-9921 (Electronic) Linking ISSN: 0014312X NLM ISO Abbreviation: Eur Surg Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, New York, Karger. |
| مواضيع طبية MeSH: | Kidney* , Kidney Transplantation* , Transplants*, Organ Preservation/*instrumentation , Perfusion/*instrumentation, Adult ; Aged ; Feasibility Studies ; Female ; Humans ; Male ; Middle Aged ; Perfusion/statistics & numerical data ; Pilot Projects ; Young Adult |
| مستخلص: | Background: The shortage of donor kidneys has led to the use of marginal donors, e.g., those whose kidneys are donated after circulatory death. Preservation of the graft by hypothermic machine perfusion (HMP) provides a viable solution to reduce warm ischemic damage. This pilot study was undertaken to assess the feasibility and patient safety of the AirdriveTM HMP system in clinical kidney transplantation. Methods: Five deceased-donor kidneys were preserved using the oxygenated Airdrive HMP system between arrival at the recipient center (Amsterdam UMC) and implantation in the patient. The main study end-points were adverse effects due to the use of Airdrive HMP. Secondary end-points were clinical outcomes and perfusion parameters. All events occurring during the transplantation procedure or within 1 month of follow-up were monitored. Results: Five patients were included in this pilot study. No technical failures were observed during the preservation period using the Airdrive HMP. Mean perfusion parameters were: duration 8.5 h (3-15 h), pressure 25 mm Hg (18-25 mm Hg), flow 49.77 mL/min (19-58 mL/min), resistance 0.57 mm Hg/min/mL (0.34-1.3 mm Hg/min/mL), and temperature 8.2 °C (2-13°C). Mean cold ischemia time (CIT) was 20.2 h (11-29.5 h). No adverse events or technical failures were observed during preservation and transplantation or during the 1-month follow-up. Conclusions: This pilot study showed the feasibility of the use of the Airdrive HMP system with no adverse events in clinical kidney transplantation. (© 2021 The Author(s) Published by S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Clinical kidney transplantation; Kidney graft preservation; Machine perfusion |
| تواريخ الأحداث: | Date Created: 20210218 Date Completed: 20211108 Latest Revision: 20211108 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1159/000513493 |
| PMID: | 33601390 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1421-9921 |
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| DOI: | 10.1159/000513493 |