دورية أكاديمية
Ouabain induces memory impairment and alter the BDNF signaling pathway in an animal model of bipolar disorder: Cognitive and neurochemical alterations in BD model.
| العنوان: | Ouabain induces memory impairment and alter the BDNF signaling pathway in an animal model of bipolar disorder: Cognitive and neurochemical alterations in BD model. |
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| المؤلفون: | Valvassori SS; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil. Electronic address: samiravalvassori@unesc.net., Dal-Pont GC; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Varela RB; Queensland Brain Institute, The Universty of Queensland, St Lucia, QLD 4072, Australia., Resende WR; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Gava FF; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Mina FG; Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Budni J; Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Quevedo J; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil; Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States; Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States; Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, United States. |
| المصدر: | Journal of affective disorders [J Affect Disord] 2021 Mar 01; Vol. 282, pp. 1195-1202. Date of Electronic Publication: 2020 Dec 31. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Bipolar Disorder*/chemically induced , Ouabain*/toxicity, Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Cognition ; Disease Models, Animal ; Hippocampus/metabolism ; Humans ; Rats ; Rats, Wistar ; Signal Transduction |
| مستخلص: | Background: The present study aims to evaluate the effects of ouabain on memory and neurotrophic parameters in the brains of rats. Methods: Wistar rats received an intracerebroventricular (ICV) injection of ouabain or artificial cerebrospinal fluid (aCSF). Seven and 14 days after ICV administration, the animals were subjected to the open-field and splash tests. Furthermore, the pro-BDNF, BDNF, TrkB, and CREB were assessed in the frontal cortex and hippocampus of the rats, in both seven and 14 days after ICV injection. The memory of the animals was tested by novel object recognition test (NOR) and inhibitory avoidance task (IA), only 14 days after ICV administration. Results: Ouabain increased locomotion and exploration in the animals seven days after its administration; however, 14 days after ICV, these behavioral parameters return to the basal level. Seven days after ouabain administration increased grooming behavior in the splash test; on the other hand, seven days after ouabain injection decreased the grooming behavior, which is considered an anhedonic response. Besides, ouabain decreased recognition index in the NOR and decreased aversive memory in the IA, when compared to the control group. The levels of pro-BDNF and BDNF decreased in the frontal cortex seven days after ouabain; but its receptor (TrkB) and CREB decreased seven and 14 days after ouabain, in both cerebral structures evaluated. Conclusion: Ouabain-induced animal model of BD is an excellent model to assess memory alteration, observed in bipolar patients. Besides, the memory impairment induced by ouabain seems to be related to BDNF signaling pathway alterations. (Copyright © 2021. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: BDNF; Bipolar disorder; CREB; Depression; Mania; Na(+)K(+)ATPase; Ouabain; TrkB |
| المشرفين على المادة: | 0 (Brain-Derived Neurotrophic Factor) 5ACL011P69 (Ouabain) |
| تواريخ الأحداث: | Date Created: 20210219 Date Completed: 20210426 Latest Revision: 20210426 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jad.2020.12.190 |
| PMID: | 33601696 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-2517 |
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| DOI: | 10.1016/j.jad.2020.12.190 |