دورية أكاديمية
أعرض في EDS

Infants with congenital heart defects have reduced brain volumes.

التفاصيل البيبلوغرافية
العنوان: Infants with congenital heart defects have reduced brain volumes.
المؤلفون: Skotting MB; Department of Thoracic and Cardiovascular Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Aarhus, Denmark. mbskotting@gmail.com., Eskildsen SF; Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Ovesen AS; Department of Thoracic and Cardiovascular Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Aarhus, Denmark., Fonov VS; Montreal Neurological Institute, McGill University, Montreal, QC, Canada., Ringgaard S; MR Research Centre, Aarhus University, Aarhus, Denmark.; Institute for Clinical Medicine, Aarhus University, Aarhus, Denmark., Hjortdal VE; Institute for Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Cardiothoracic Surgery, Rigshospitalet, Copenhagen, Denmark., Lauridsen MH; Institute for Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.
المصدر: Scientific reports [Sci Rep] 2021 Feb 18; Vol. 11 (1), pp. 4191. Date of Electronic Publication: 2021 Feb 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Brain/*pathology , Heart Defects, Congenital/*pathology, Female ; Humans ; Infant ; Magnetic Resonance Imaging/methods ; Male ; Neuroimaging/methods
مستخلص: Children with congenital heart defects (CHDs) have increased risk of cognitive disabilities for reasons not fully understood. Previous studies have indicated signs of disrupted fetal brain growth from mid-gestation measured with ultrasound and magnetic resonance imaging (MRI) and infants with CHDs have decreased brain volumes at birth. We measured the total and regional brain volumes of infants with and without CHDs using MRI to investigate, if certain areas of the brain are at particular risk of disrupted growth. MRI brain volumetry analyses were performed on 20 infants; 10 with- (postmenstrual age 39-54 weeks, mean 44 weeks + 5 days) and 10 without CHDs (postmenstrual age 39-52 weeks, mean 43 weeks + 5 days). In six infants with- and eight infants without CHDs grey and white matter were also differentiated. Infants with CHDs had smaller brains (48 ml smaller; 95% CI, 6.1-90; p = 0.03), cerebrums (37.8 ml smaller; 95% CI, 0.8-74.8; p = 0.04), and cerebral grey matter (25.8 ml smaller; 95% CI, 3.5-48; p = 0.03) than infants without CHD. Brain volume differences observed within weeks after birth in children with CHDs confirm that the brain impact, which increase the risk of cognitive disabilities, may begin during pregnancy.
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تواريخ الأحداث: Date Created: 20210219 Date Completed: 20211207 Latest Revision: 20211214
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7892565
DOI: 10.1038/s41598-021-83690-3
PMID: 33603031
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-021-83690-3