دورية أكاديمية
أعرض في EDS

Development of nasal allergen challenge with cockroach in children with asthma.

التفاصيل البيبلوغرافية
العنوان: Development of nasal allergen challenge with cockroach in children with asthma.
المؤلفون: Rudman Spergel AK; Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Sever ML; Rho, Inc., Durham, NC, USA., Johnson J; Rho, Inc., Durham, NC, USA., Gill MA; Departments of Pediatrics, Internal Medicine, and Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Schulten V; La Jolla Institute for Immunology, La Jolla, CA, USA., Frazier A; La Jolla Institute for Immunology, La Jolla, CA, USA., Kercsmar CM; Department of Pediatrics, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Lovinsky-Desir S; Department of Pediatrics, Division of Pulmonary Medicine, Columbia University Irving Medical Center, New York, NY, USA., Searing DA; Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA., Sette A; La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Medicine, University of California San Diego, La Jolla, CA, USA., Shao B; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Teach SJ; Children's National Hospital, Washington, DC, USA., Gern JE; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA., Busse WW; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA., Togias A; Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Wood RA; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Liu AH; Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA.
مؤلفون مشاركون: National Institute of Allergy and Infectious Diseases Inner City Asthma Consortium
المصدر: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology [Pediatr Allergy Immunol] 2021 Jul; Vol. 32 (5), pp. 971-979. Date of Electronic Publication: 2021 Mar 20.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Blackwell Publishing Country of Publication: England NLM ID: 9106718 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-3038 (Electronic) Linking ISSN: 09056157 NLM ISO Abbreviation: Pediatr Allergy Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2010->: Oxford, UK : Blackwell Publishing
Original Publication: Copenhagen : Munksgaard, c1990-
مواضيع طبية MeSH: Asthma*/drug therapy , Cockroaches*, Allergens ; Animals ; Child ; Humans ; Leukocytes, Mononuclear ; Nasal Provocation Tests
مستخلص: Background: Nasal allergen challenge (NAC) could be a means to assess indication and/or an outcome of allergen-specific therapies, particularly for perennial allergens. NACs are not commonly conducted in children with asthma, and cockroach NACs are not well established. This study's objective was to identify a range of German cockroach extract doses that induce nasal symptoms and to assess the safety of cockroach NAC in children with asthma.
Methods: Ten adults (18-37 years) followed by 25 children (8-14 years) with well-controlled, persistent asthma and cockroach sensitization underwent NAC with diluent followed by up to 8 escalating doses of cockroach extract (0.00381-11.9 µg/mL Bla g 1). NAC outcome was determined by Total Nasal Symptom Score (TNSS) and/or sneeze score. Cockroach allergen-induced T-cell activation and IL-5 production were measured in peripheral blood mononuclear cells.
Results: 67% (6/9) of adults and 68% (17/25) of children had a positive NAC at a median response dose of 0.120 µg/mL [IQR 0.0380-0.379 µg/mL] of Bla g 1. Additionally, three children responded to diluent alone and did not receive any cockroach extract. Overall, 32% (11/34) were positive with sneezes alone, 15% (5/34) with TNSS alone, and 21% (7/34) with both criteria. At baseline, NAC responders had higher cockroach-specific IgE (P = .03), lower cockroach-specific IgG/IgE ratios (children, P = .002), and increased cockroach-specific IL-5-producing T lymphocytes (P = .045). The NAC was well tolerated.
Conclusion: We report the methodology of NAC development for children with persistent asthma and cockroach sensitization. This NAC could be considered a tool to confirm clinically relevant sensitization and to assess responses in therapeutic studies.
(© 2021 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This article has been contributed to by US Government employees and their work is in the public domain in the USA.)
References: Int Arch Allergy Immunol. 2016;170(2):115-21. (PMID: 27475650)
Nihon Jibiinkoka Gakkai Kaiho. 2002 Dec;105(12):1181-8. (PMID: 12607279)
Allergy. 2002 Dec;57(12):1200-4. (PMID: 12464051)
J Immunol Methods. 2012 Oct 31;384(1-2):25-32. (PMID: 22759401)
Allergy. 1998 Oct;53(10):990-4. (PMID: 9821481)
N Engl J Med. 1997 May 8;336(19):1356-63. (PMID: 9134876)
J Allergy Clin Immunol. 2019 Oct;144(4):935-944. (PMID: 31201891)
J Immunol. 2010 Jul 15;185(2):943-55. (PMID: 20554959)
J Immunol. 2016 Mar 1;196(5):2004-9. (PMID: 26826244)
Am Rev Respir Dis. 1983 Oct;128(4):597-602. (PMID: 6354022)
Clin Transl Allergy. 2018 Apr 12;8:15. (PMID: 29682277)
J Allergy Clin Immunol. 2011 Jun;127(6):1480-5. (PMID: 21492924)
Clin Exp Allergy. 2017 Sep;47(9):1193-1203. (PMID: 28681506)
J Immunol. 2000 Oct 1;165(7):4062-8. (PMID: 11034417)
Allergy. 1996 Aug;51(8):582-6. (PMID: 8874663)
Environ Health Perspect. 2005 Jun;113(6):665-9. (PMID: 15929886)
Allergy. 2002 Aug;57(8):701-5. (PMID: 12121188)
J Allergy Clin Immunol. 2014 Mar;133(3):846-52.e6. (PMID: 24184147)
J Immunol. 2016 Aug 1;197(3):983-93. (PMID: 27342848)
Ann Allergy Asthma Immunol. 2017 Jul;119(1):65-70.e3. (PMID: 28668242)
Biologicals. 2007 Apr;35(2):131-7. (PMID: 17071100)
JAMA. 2017 Feb 14;317(6):615-625. (PMID: 28196255)
N Engl J Med. 2004 Sep 9;351(11):1068-80. (PMID: 15356304)
Ann Allergy. 1970 Dec;28(12):596-9. (PMID: 5521191)
Int Arch Allergy Immunol. 1998 Nov;117(3):180-6. (PMID: 9831805)
Ann Allergy Asthma Immunol. 2008 Jun;100(6):533-7. (PMID: 18592815)
Respir Med. 2007 Jul;101(7):1600-8. (PMID: 17482451)
J Allergy Clin Immunol. 2016 Feb;137(2):379-87. (PMID: 26518094)
Allergol Immunopathol (Madr). 2011 Jan-Feb;39(1):17-22. (PMID: 20675034)
Clin Exp Allergy. 2015 Mar;45(3):613-23. (PMID: 25303516)
J Immunol. 2010 Jun 1;184(11):5999-6006. (PMID: 20410486)
معلومات مُعتمدة: UL1 TR000150 United States TR NCATS NIH HHS; UL1 TR001105 United States TR NCATS NIH HHS; UL1 TR000075 United States TR NCATS NIH HHS; UL1 RR025780 United States RR NCRR NIH HHS; Z99 AI999999 United States ImNIH Intramural NIH HHS; UL1 TR000154 United States TR NCATS NIH HHS; UM2 AI117870 United States AI NIAID NIH HHS; UL1 TR001422 United States TR NCATS NIH HHS; UL1 TR001082 United States TR NCATS NIH HHS; HHSN272200900052C United States AI NIAID NIH HHS; HHSN272201000052I United States AI NIAID NIH HHS; UL1 TR000451 United States TR NCATS NIH HHS; UM1 AI114271 United States AI NIAID NIH HHS; UL1 TR000040 United States TR NCATS NIH HHS; UL1 TR000077 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: allergic rhinitis; asthma; children; cockroach allergy; inner city; nasal allergen challenge
سلسلة جزيئية: ClinicalTrials.gov NCT02710136
المشرفين على المادة: 0 (Allergens)
تواريخ الأحداث: Date Created: 20210219 Date Completed: 20210831 Latest Revision: 20240923
رمز التحديث: 20240923
مُعرف محوري في PubMed: PMC8503840
DOI: 10.1111/pai.13480
PMID: 33606312
قاعدة البيانات: MEDLINE
الوصف
تدمد:1399-3038
DOI:10.1111/pai.13480