دورية أكاديمية
Therapeutic induction of tolerogenic dendritic cells via aryl hydrocarbon receptor signaling.
| العنوان: | Therapeutic induction of tolerogenic dendritic cells via aryl hydrocarbon receptor signaling. |
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| المؤلفون: | Barroso A; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Mahler JV; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil., Fonseca-Castro PH; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil., Quintana FJ; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: fquintana@rics.bwh.harvard.edu. |
| المصدر: | Current opinion in immunology [Curr Opin Immunol] 2021 Jun; Vol. 70, pp. 33-39. Date of Electronic Publication: 2021 Feb 16. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8900118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0372 (Electronic) Linking ISSN: 09527915 NLM ISO Abbreviation: Curr Opin Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : London : Elsevier Original Publication: Philadelphia, PA, USA : Current Science, c1988- |
| مواضيع طبية MeSH: | Basic Helix-Loop-Helix Transcription Factors/*immunology , Dendritic Cells/*immunology , Receptors, Aryl Hydrocarbon/*immunology, Autoimmune Diseases/immunology ; Humans ; Hypersensitivity/immunology ; Signal Transduction/immunology |
| مستخلص: | Dendritic cells (DCs) are potent antigen-presenting cells (APCs), which sample the exogenous and endogenous cues to control adaptive immunity, balancing effector and regulatory components of the immune response. Multiple subsets of DCs, such as plasmacytoid and conventional DCs, have been defined based on specific phenotypic markers, functions and regulatory transcriptional programs. Tolerogenic DCs (tolDCs) have been functionally defined based on their ability to expand the regulatory T-cell compartment and suppress immune responses. However, it is still unclear whether tolDCs represent a homogeneous population, a specific DC subset and/or a heterogeneous collection of DC activation/maturation states. The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) has been shown to control transcriptional programs associated to tolDCs. In this review, we discuss the role of AHR in the control of tolDCs, and also AHR-targeted approaches for the therapeutic induction of tolDCs in autoimmune diseases and allergy. (Copyright © 2021 Elsevier Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (AHR protein, human) 0 (Basic Helix-Loop-Helix Transcription Factors) 0 (Receptors, Aryl Hydrocarbon) |
| تواريخ الأحداث: | Date Created: 20210219 Date Completed: 20220117 Latest Revision: 20220117 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.coi.2021.02.003 |
| PMID: | 33607496 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-0372 |
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| DOI: | 10.1016/j.coi.2021.02.003 |