دورية أكاديمية
Engineering multifunctional bactericidal nanofibers for abdominal hernia repair.
العنوان: | Engineering multifunctional bactericidal nanofibers for abdominal hernia repair. |
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المؤلفون: | Afewerki S; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. samsonafewerki20@gmail.com.; Division of Health Sciences and Technology, Harvard University ‒ Massachusetts Institute of Technology, Cambridge, MA, USA. samsonafewerki20@gmail.com., Bassous N; Nanomedicine Laboratory, Department of Chemical Engineering, Northeastern University, Boston, MA, USA., Harb SV; Nanomedicine Laboratory, Department of Chemical Engineering, Northeastern University, Boston, MA, USA.; Institute of Chemistry, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil., Corat MAF; Multidisciplinary Center for Biological Research, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil., Maharjan S; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Health Sciences and Technology, Harvard University ‒ Massachusetts Institute of Technology, Cambridge, MA, USA., Ruiz-Esparza GU; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Health Sciences and Technology, Harvard University ‒ Massachusetts Institute of Technology, Cambridge, MA, USA., de Paula MMM; Multidisciplinary Center for Biological Research, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil., Webster TJ; Nanomedicine Laboratory, Department of Chemical Engineering, Northeastern University, Boston, MA, USA., Tim CR; Brasil University, Itaquera, São Paulo, Brazil., Viana BC; LIMAV - Interdisciplinary Laboratory for Advanced Materials, Materials Science & Engineering Graduate Program, UFPI - Federal University of Piaui, Teresina, Piaui, Brazil.; Department of Physics, Federal University of Piaui, Teresina, Piaui, Brazil., Wang D; Nanomedicine Laboratory, Department of Chemical Engineering, Northeastern University, Boston, MA, USA., Wang X; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Health Sciences and Technology, Harvard University ‒ Massachusetts Institute of Technology, Cambridge, MA, USA., Marciano FR; Nanomedicine Laboratory, Department of Chemical Engineering, Northeastern University, Boston, MA, USA.; Department of Physics, Federal University of Piaui, Teresina, Piaui, Brazil., Lobo AO; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. lobo@ufpi.edu.br.; Division of Health Sciences and Technology, Harvard University ‒ Massachusetts Institute of Technology, Cambridge, MA, USA. lobo@ufpi.edu.br.; LIMAV - Interdisciplinary Laboratory for Advanced Materials, Materials Science & Engineering Graduate Program, UFPI - Federal University of Piaui, Teresina, Piaui, Brazil. lobo@ufpi.edu.br.; Department of Chemistry, Massachusetts Institute of Technology, MIT, Cambridge, MA, USA. lobo@ufpi.edu.br. |
المصدر: | Communications biology [Commun Biol] 2021 Feb 19; Vol. 4 (1), pp. 233. Date of Electronic Publication: 2021 Feb 19. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London, United Kingdom : Nature Publishing Group UK, [2018]- |
مواضيع طبية MeSH: | Biocompatible Materials* , Nanofibers* , Tissue Scaffolds*, Anti-Bacterial Agents/*pharmacology , Gelatin/*pharmacology , Hernia, Abdominal/*surgery , Herniorrhaphy/*instrumentation , Methacrylates/*pharmacology , Polyesters/*pharmacology , Surgical Wound Infection/*prevention & control, Animals ; Anti-Bacterial Agents/chemistry ; Disease Models, Animal ; Gelatin/chemistry ; Hernia, Abdominal/pathology ; Methacrylates/chemistry ; Mice ; NIH 3T3 Cells ; Nanomedicine ; Polyesters/chemistry ; Rats ; Surgical Wound Infection/microbiology ; Wound Healing/drug effects |
مستخلص: | The engineering of multifunctional surgical bactericidal nanofibers with inherent suitable mechanical and biological properties, through facile and cheap fabrication technology, is a great challenge. Moreover, hernia, which is when organ is pushed through an opening in the muscle or adjacent tissue due to damage of tissue structure or function, is a dire clinical challenge that currently needs surgery for recovery. Nevertheless, post-surgical hernia complications, like infection, fibrosis, tissue adhesions, scaffold rejection, inflammation, and recurrence still remain important clinical problems. Herein, through an integrated electrospinning, plasma treatment and direct surface modification strategy, multifunctional bactericidal nanofibers were engineered showing optimal properties for hernia repair. The nanofibers displayed good bactericidal activity, low inflammatory response, good biodegradation, as well as optimal collagen-, stress fiber- and blood vessel formation and associated tissue ingrowth in vivo. The disclosed engineering strategy serves as a prominent platform for the design of other multifunctional materials for various biomedical challenges. |
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المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Biocompatible Materials) 0 (Methacrylates) 0 (Polyesters) 0 (gelatin methacryloyl) 24980-41-4 (polycaprolactone) 9000-70-8 (Gelatin) |
تواريخ الأحداث: | Date Created: 20210220 Date Completed: 20210810 Latest Revision: 20240330 |
رمز التحديث: | 20240330 |
مُعرف محوري في PubMed: | PMC7896057 |
DOI: | 10.1038/s42003-021-01758-2 |
PMID: | 33608611 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2399-3642 |
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DOI: | 10.1038/s42003-021-01758-2 |