دورية أكاديمية
Activity of MSI-78, h-Lf1-11 and cecropin B antimicrobial peptides alone and in combination with voriconazole and amphotericin B against clinical isolates of Fusarium solani.
العنوان: | Activity of MSI-78, h-Lf1-11 and cecropin B antimicrobial peptides alone and in combination with voriconazole and amphotericin B against clinical isolates of Fusarium solani. |
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المؤلفون: | Denardi LB; Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Avenida Roraima, n(o) 1000, Prédio 20, sala 4139, CEP 97105-900, Santa Maria, RS, Brazil. Electronic address: laura-denardi@hotmail.com., Weiblen C; Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Avenida Roraima, n(o) 1000, Prédio 20, sala 4139, CEP 97105-900, Santa Maria, RS, Brazil., Ianiski LB; Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Avenida Roraima, n(o) 1000, Prédio 20, sala 4139, CEP 97105-900, Santa Maria, RS, Brazil., Stibbe PC; Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Avenida Roraima, n(o) 1000, Prédio 20, sala 4139, CEP 97105-900, Santa Maria, RS, Brazil., Santurio JM; Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Avenida Roraima, n(o) 1000, Prédio 20, sala 4139, CEP 97105-900, Santa Maria, RS, Brazil. |
المصدر: | Journal de mycologie medicale [J Mycol Med] 2021 Jun; Vol. 31 (2), pp. 101119. Date of Electronic Publication: 2021 Feb 03. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Masson Country of Publication: France NLM ID: 9425651 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1773-0449 (Electronic) Linking ISSN: 11565233 NLM ISO Abbreviation: J Mycol Med Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Paris : Masson, 1991- |
مواضيع طبية MeSH: | Amphotericin B/*pharmacology , Antifungal Agents/*pharmacology , Fusarium/*drug effects , Pore Forming Cytotoxic Proteins/*pharmacology , Voriconazole/*pharmacology, Drug Combinations ; Drug Synergism ; Humans ; Microbial Sensitivity Tests ; Pore Forming Cytotoxic Proteins/classification |
مستخلص: | Fusarium infections have been associated with high mortality rates due to the lack of definition of an ideal treatment strategy. Antimicrobial peptides (AMPs) have potential antifungal activity. Therefore, investigating the in vitro activity of these molecules alone and in association with conventional antifungals against clinical isolates of Fusarium was the aim of this study. Fusarium solani (n=10) strains were tested against the AMPs, MSI-78, h-Lf1-11 and cecropin B in accordance with CLSI protocol. Further, a checkerboard assay for its combination with amphotericin B or voriconazole, was carried out. MSI-78, h-Lf1-11 and cecropin B exhibited antifungal activity against F. solani strains tested with MICs ranging from 20 to 320mg/L. Satisfactory percentage of synergism was demonstrated for all evaluated combinations, ranging from 70 to 100%. The use of AMPs combined with amphotericin B and voriconazole antifungals has great synergistic potential and deserve to be evaluated in murine models of fusariosis. (Copyright © 2021 Elsevier Masson SAS. All rights reserved.) |
فهرسة مساهمة: | Keywords: Antimicrobial peptides; Cecropin B; Fusarium solani; MSI-78; h-Lf1-11 |
المشرفين على المادة: | 0 (Antifungal Agents) 0 (Drug Combinations) 0 (Pore Forming Cytotoxic Proteins) 7XU7A7DROE (Amphotericin B) JFU09I87TR (Voriconazole) |
SCR Organism: | Fusarium solani |
تواريخ الأحداث: | Date Created: 20210224 Date Completed: 20211020 Latest Revision: 20211020 |
رمز التحديث: | 20231215 |
DOI: | 10.1016/j.mycmed.2021.101119 |
PMID: | 33626413 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1773-0449 |
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DOI: | 10.1016/j.mycmed.2021.101119 |