دورية أكاديمية
أعرض في EDS

Relationship Between Pituitary Siderosis and Endocrinological Disorders in Pediatric Patients with Beta-Thalassemia.

التفاصيل البيبلوغرافية
العنوان: Relationship Between Pituitary Siderosis and Endocrinological Disorders in Pediatric Patients with Beta-Thalassemia.
المؤلفون: Yılmaz K; Pediatrics, Dicle University School of Medicine, Diyarbakir, TUR., Kan A; Pediatric Allergy, Dicle University School of Medicine, Diyarbakir, TUR., Çetincakmak MG; Radiology, Memorial Regional Hospital, Diyarbakir, TUR., Uzel VH; Pediatric Oncology, Dicle University School of Medicine, Diyarbakir, TUR., Yılmaz D; Pathology, Dicle University School of Medicine, Diyarbakir, TUR., Deniz MA; Radiology, Dicle University School of Medicine, Diyarbakir, TUR., Hattapoglu S; Radiology, Dicle University School of Medicine, Diyarbakir, TUR.
المصدر: Cureus [Cureus] 2021 Jan 23; Vol. 13 (1), pp. e12877. Date of Electronic Publication: 2021 Jan 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: Electronic Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Introduction Excess iron accumulation occurs mainly in organs such as reticuloendothelial cells, the pituitary gland, and the pancreas in beta-thalassemia because of blood transfusions. In the present study, it was aimed to investigate the relationship between T2* values on magnetic resonance imaging (MRI) and clinically diagnosed pituitary endocrinological disorders in children with thalassemia major. Methods This study enrolled patients diagnosed with beta-thalassemia at pediatric hematology outpatient clinics. In the study, in addition to the medical history of the patients, routinely performed tests, including hemoglobin electrophoresis, routine biochemical tests, and tests for pubertal development (follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, testosterone, etc.), as well as iron deposition measured by hepatic MRI T2* (STAR) sequence, were retrospectively assessed. A total of 29 patients were enrolled. Results Hypothyroidism was detected in 34.6% (9/26) of patients, short stature in 37% (10/27), and pubertal retardation in 50% (14/28) of the patients. There was no significant correlation between hypothyroidism and pituitary MRI T2* values. No significant correlation was found between laboratory parameters and pituitary MRI examination. Although the sensitivity of T2* levels could rise above 80%, their specificity remained low. This is one of the major limitations of the pituitary MR T2* study for the prediction of short stature. The best lower cut-off level of MR T2* to predict short stature was found 14.6 ms. Conclusion The diagnostic specificity pituitary MR examination levels for short stature were detected as low. Thus, the clinical standardization and validation of pituitary MR T2* values examination are needed before clinical follow-up and multifaceted studies are needed.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2021, Yılmaz et al.)
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فهرسة مساهمة: Keywords: beta thalassemia; pituitary mri; siderosis; t2
تواريخ الأحداث: Date Created: 20210226 Latest Revision: 20210227
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7899051
DOI: 10.7759/cureus.12877
PMID: 33633906
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.12877