دورية أكاديمية
Hematopoietic stem and progenitor cells are present in healthy gingiva tissue.
| العنوان: | Hematopoietic stem and progenitor cells are present in healthy gingiva tissue. |
|---|---|
| المؤلفون: | Krishnan S; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Wemyss K; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Prise IE; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., McClure FA; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., O'Boyle C; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Bridgeman HM; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Shaw TN; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK., Grainger JR; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Konkel JE; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK. |
| المصدر: | The Journal of experimental medicine [J Exp Med] 2021 Apr 05; Vol. 218 (4). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Rockefeller University Press |
| مواضيع طبية MeSH: | Gingiva/*cytology , Gingiva/*immunology , Myeloid Progenitor Cells/*cytology , Myeloid Progenitor Cells/*immunology, Animals ; Bone Marrow/metabolism ; Female ; Hematopoiesis ; Male ; Mice ; Mice, Inbred C57BL ; Mouth Mucosa/cytology ; Mouth Mucosa/immunology ; RNA-Seq/methods ; Single-Cell Analysis/methods |
| مستخلص: | Hematopoietic stem cells reside in the bone marrow, where they generate the effector cells that drive immune responses. However, in response to inflammation, some hematopoietic stem and progenitor cells (HSPCs) are recruited to tissue sites and undergo extramedullary hematopoiesis. Contrasting with this paradigm, here we show residence and differentiation of HSPCs in healthy gingiva, a key oral barrier in the absence of overt inflammation. We initially defined a population of gingiva monocytes that could be locally maintained; we subsequently identified not only monocyte progenitors but also diverse HSPCs within the gingiva that could give rise to multiple myeloid lineages. Gingiva HSPCs possessed similar differentiation potentials, reconstitution capabilities, and heterogeneity to bone marrow HSPCs. However, gingival HSPCs responded differently to inflammatory insults, responding to oral but not systemic inflammation. Combined, we highlight a novel pathway of myeloid cell development at a healthy barrier, defining a gingiva-specific HSPC network that supports generation of a proportion of the innate immune cells that police this barrier. Competing Interests: Disclosures: The authors declare no competing interests exist. (© 2021 Krishnan et al.) |
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| معلومات مُعتمدة: | 097820/Z/11/B United Kingdom WT_ Wellcome Trust; BB/M025977/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; MR/L011840/1 United Kingdom MRC_ Medical Research Council; 21927 United Kingdom VAC_ Versus Arthritis; United Kingdom WT_ Wellcome Trust; BB/S01130X/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council |
| تواريخ الأحداث: | Date Created: 20210226 Date Completed: 20211006 Latest Revision: 20220310 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC7923695 |
| DOI: | 10.1084/jem.20200737 |
| PMID: | 33635312 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1540-9538 |
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| DOI: | 10.1084/jem.20200737 |