دورية أكاديمية
Chloracne: a case series on cutaneous expression of CYP1A1 as diagnostic biomarker.
| العنوان: | Chloracne: a case series on cutaneous expression of CYP1A1 as diagnostic biomarker. |
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| المؤلفون: | Chessa MA; Dermatology Unit, IRCCS Sant'Orsola Policlinic, University of Bologna, Bologna, Italy., La Placa M; Dermatology Unit, IRCCS Sant'Orsola Policlinic, University of Bologna, Bologna, Italy., Patrizi A; Dermatology Unit, IRCCS Sant'Orsola Policlinic, University of Bologna, Bologna, Italy., Virdi A; Dermatology Unit, IRCCS Sant'Orsola Policlinic, University of Bologna, Bologna, Italy., Misciali C; Dermatology Unit, IRCCS Sant'Orsola Policlinic, University of Bologna, Bologna, Italy., Fedrizzi G; Chemical Department, Istituto Zooprofilattico Sperimentale Lombardia Emilia Romagna, Bologna, Italy., Filippi F; Dermatology Unit, IRCCS Sant'Orsola Policlinic, University of Bologna, Bologna, Italy., Saurat JH; Dermatotoxicology Unit, Swiss Centre for Applied Human Toxicology, University of Geneva, Geneva, Switzerland., Sorg O; Dermatotoxicology Unit, Swiss Centre for Applied Human Toxicology, University of Geneva, Geneva, Switzerland., Fontao F; Dermatotoxicology Unit, Swiss Centre for Applied Human Toxicology, University of Geneva, Geneva, Switzerland., Kaya G; Departments of, Dermatology, University Hospital of Geneva, Geneva, Switzerland.; Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland., Neri I; Dermatology Unit, IRCCS Sant'Orsola Policlinic, University of Bologna, Bologna, Italy. |
| المصدر: | Clinical and experimental dermatology [Clin Exp Dermatol] 2021 Jul; Vol. 46 (5), pp. 896-900. Date of Electronic Publication: 2021 Apr 26. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 7606847 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2230 (Electronic) Linking ISSN: 03076938 NLM ISO Abbreviation: Clin Exp Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : Oxford : Oxford University Press Original Publication: Oxford : Blackwell Scientific Publications. |
| مواضيع طبية MeSH: | Acneiform Eruptions/*pathology , Chloracne/*metabolism , Cytochrome P-450 CYP1A1/*metabolism , Dioxins/*toxicity , Polychlorinated Dibenzodioxins/*toxicity, Acneiform Eruptions/etiology ; Acneiform Eruptions/metabolism ; Adult ; Biomarkers/metabolism ; Child ; Chloracne/diagnosis ; Chloracne/etiology ; Environmental Exposure/adverse effects ; Female ; Humans ; Immunohistochemistry/methods ; Italy/epidemiology ; Male ; Pakistan/ethnology ; Polychlorinated Biphenyls/adverse effects ; Polychlorinated Biphenyls/chemistry ; Receptors, Aryl Hydrocarbon/chemistry ; Receptors, Aryl Hydrocarbon/metabolism ; Retrospective Studies |
| مستخلص: | Chloracne, also known as metabolizing acquired dioxin-induced skin hamartomas (MADISH), is a rare disfiguring disease related to dioxin exposure. There is a paucity of literature on the clinical manifestations and pathogenesis of chloracne/MADISH. The aim of this study was to assess the clinical features of this very unusual acneiform eruption and to explore the pathogenesis of the disease. This was a retrospective, observational report study was conducted on five patients belonging to the same nuclear family (father, mother and three children) and a relative (father's brother) living in the same house. Histopathological, immunohistochemical, laboratory and toxicological analyses were performed for all patients. The results suggest that CYP1A1 in human skin is a diagnostic biomarker in chloracne, and was positive for all the patients in our sample. Tetrachlorodibenzo-p-dioxin is the most investigated dioxin responsible for chloracne; however, several other agonists, whether dioxin-like or not, can activate the aryl hydrocarbon receptor. To our knowledge, this Italian case series is the first study to suggest polychlorinated biphenyls as a possible cause of an overstimulation of aryl hydrocarbons causing the consequent acneiform eruption. (© 2021 British Association of Dermatologists.) |
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| المشرفين على المادة: | 0 (Biomarkers) 0 (Dioxins) 0 (Polychlorinated Dibenzodioxins) 0 (Receptors, Aryl Hydrocarbon) DFC2HB4I0K (Polychlorinated Biphenyls) EC 1.14.14.1 (CYP1A1 protein, human) EC 1.14.14.1 (Cytochrome P-450 CYP1A1) |
| تواريخ الأحداث: | Date Created: 20210227 Date Completed: 20211129 Latest Revision: 20211129 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/ced.14617 |
| PMID: | 33638914 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-2230 |
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| DOI: | 10.1111/ced.14617 |