دورية أكاديمية
أعرض في EDS

Emerging evidence that adaptive bone formation inhibition by non-steroidal anti-inflammatory drugs increases stress fracture risk.

التفاصيل البيبلوغرافية
العنوان: Emerging evidence that adaptive bone formation inhibition by non-steroidal anti-inflammatory drugs increases stress fracture risk.
المؤلفون: Staab JS; Military Performance Division, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, USA., Kolb AL; Military Performance Division, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, USA., Tomlinson RE; Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA., Pajevic PD; Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA., Matheny RW Jr; Military Operational Medicine Research Program, Fort Detrick, MD 21702, USA., Hughes JM; Military Performance Division, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, USA.
المصدر: Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2021 May; Vol. 246 (9), pp. 1104-1111. Date of Electronic Publication: 2021 Feb 27.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: England NLM ID: 100973463 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3699 (Electronic) Linking ISSN: 15353699 NLM ISO Abbreviation: Exp Biol Med (Maywood) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2024- : Lausanne, Switzerland : Frontiers Media S.A.
Original Publication: Maywood, NJ : The Society, c2001-
مواضيع طبية MeSH: Fractures, Stress*/chemically induced , Fractures, Stress*/physiopathology, Anti-Inflammatory Agents, Non-Steroidal/*adverse effects , Bone Remodeling/*drug effects , Osteogenesis/*drug effects, Animals ; Humans
مستخلص: There is mounting evidence suggesting that the commonly used analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), may inhibit new bone formation with physical training and increase risk of stress fractures in physically active populations. Stress fractures are thought to occur when bones are subjected to repetitive mechanical loading, which can lead to a cycle of tissue microdamage, repair, and continued mechanical loading until fracture. Adaptive bone formation, particularly on the periosteal surface of long bones, is a concurrent adaptive response of bone to heightened mechanical loading that can improve the fatigue resistance of the skeletal structure, and therefore may play a critical role in offsetting the risk of stress fracture. Reports from animal studies suggest that NSAID administration may suppress this important adaptive response to mechanical loading. These observations have implications for populations such as endurance athletes and military recruits who are at risk of stress fracture and whose use of NSAIDs is widespread. However, results from human trials evaluating exercise and bone adaptation with NSAID consumption have been less conclusive. In this review, we identify knowledge gaps that must be addressed to further support NSAID-related guidelines intended for at-risk populations and individuals.
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فهرسة مساهمة: Keywords: Non-steroidal anti-inflammatory drugs; bone; cyclooxygenase; mechanical loading; prostaglandins; stress fracture
المشرفين على المادة: 0 (Anti-Inflammatory Agents, Non-Steroidal)
تواريخ الأحداث: Date Created: 20210301 Date Completed: 20211007 Latest Revision: 20220503
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8113733
DOI: 10.1177/1535370221993098
PMID: 33641442
قاعدة البيانات: MEDLINE
الوصف
تدمد:1535-3699
DOI:10.1177/1535370221993098