دورية أكاديمية
Protective efficacy of Barbervax® in Merino weaner sheep trickle infected with five doses of Haemonchus contortus infective larvae.
| العنوان: | Protective efficacy of Barbervax® in Merino weaner sheep trickle infected with five doses of Haemonchus contortus infective larvae. |
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| المؤلفون: | Kebeta MM; School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia; College of Agriculture and Environmental Science, Arsi University, Asella, P.O. Box 193, Ethiopia. Electronic address: mkebeta@myune.edu.au., Hine BC; CSIRO, Livestock & Aquaculture, F.D. McMaster Laboratory, Armidale, NSW 2350, Australia., Walkden-Brown SW; School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia., Kahn LP; School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia., Doyle EK; School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia. |
| المصدر: | Veterinary parasitology [Vet Parasitol] 2021 Apr; Vol. 292, pp. 109386. Date of Electronic Publication: 2021 Feb 15. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial, Veterinary |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7602745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2550 (Electronic) Linking ISSN: 03044017 NLM ISO Abbreviation: Vet Parasitol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Amsterdam : Elsevier Scientific Pub. Co. |
| مواضيع طبية MeSH: | Haemonchiasis/*veterinary , Haemonchus/*immunology , Helminth Proteins/*immunology , Sheep Diseases/*prevention & control , Vaccination/*veterinary , Vaccines/*immunology, Animals ; Anthelmintics/administration & dosage ; Feces/parasitology ; Female ; Haemonchiasis/drug therapy ; Haemonchiasis/prevention & control ; Larva ; Male ; Membrane Proteins/immunology ; Parasite Egg Count/veterinary ; Sheep ; Sheep Diseases/drug therapy ; Sheep Diseases/parasitology ; Vaccination/standards ; Vaccines/administration & dosage |
| مستخلص: | Barbervax® protects sheep against H. contortus infection; however, the level of protection afforded by the vaccine at different levels of larval challenge under field conditions has not been reported. Therefore, this study was designed to investigate the protective efficacy of Barbervax® at increasing doses of trickle infection with H. contortus third stage larvae (L3). Merino lambs (220) were randomly allocated to challenge treatment groups and received Barbervax® vaccinations at approximately 8, 11, 15 and 22 weeks of age or not vaccinated (control group). Animals within each treatment group were subjected to one of five levels of H. contortus L3 trickle infection (0, 300, 600, 1200 and 2400 L3/week in two split doses). Trickle infections started two weeks after the third vaccination (week 0). Worm egg count (WEC), packed cell volume (PCV), antibody titre and bodyweight were measured at week 2 (start of trickle infection), week 5 and then every two weeks for 11 weeks. Vaccinated weaners had a significantly (P < 0.0001) lower faecal WEC than unvaccinated control animals. Vaccination induced significant specific antibody responses that were not influenced by level of trickle infection. Vaccination significantly reduced the number of weaners requiring salvage anthelmintic treatment (9.4% vaccinated weaners versus 33.6% unvaccinated). Vaccine protective index based on WEC was similar at all challenge levels (overall mean> 60%) and at the higher challenge levels did not reduce H. contortus infection to levels that would not require anthelmintic treatment. Therefore, it is suggested that under conditions of high larval challenge the use of Barbervax® should be integrated with other control methods. (Copyright © 2021 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Barbervax®; Haemonchuscontortus; Protection index; Weaners |
| المشرفين على المادة: | 0 (Anthelmintics) 0 (Helminth Proteins) 0 (Membrane Proteins) 0 (Vaccines) |
| تواريخ الأحداث: | Date Created: 20210302 Date Completed: 20210813 Latest Revision: 20210813 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.vetpar.2021.109386 |
| PMID: | 33652209 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-2550 |
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| DOI: | 10.1016/j.vetpar.2021.109386 |