دورية أكاديمية
Diagnostic accuracy of EUS-guided through-the-needle-biopsies and simultaneously obtained fine needle aspiration for cytology from pancreatic cysts: A systematic review and meta-analysis.
| العنوان: | Diagnostic accuracy of EUS-guided through-the-needle-biopsies and simultaneously obtained fine needle aspiration for cytology from pancreatic cysts: A systematic review and meta-analysis. |
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| المؤلفون: | Rift CV; Department of Pathology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark. Electronic address: charlotte.vestrup.rift@regionh.dk., Scheie D; Department of Pathology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark., Toxværd A; Department of Pathology, Copenhagen University Hospital Herlev and Gentofte, Herlev Ringvej 75, DK 2730, Herlev, Denmark., Kovacevic B; Gastroenterology Unit, Copenhagen University Hospital Herlev and Gentofte, Herlev Ringvej 75, DK 2730, Herlev, Denmark., Klausen P; Gastroenterology Unit, Copenhagen University Hospital Herlev and Gentofte, Herlev Ringvej 75, DK 2730, Herlev, Denmark., Vilmann P; Gastroenterology Unit, Copenhagen University Hospital Herlev and Gentofte, Herlev Ringvej 75, DK 2730, Herlev, Denmark., Hansen CP; Department of Surgery, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark., Lund EL; Department of Pathology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark., Hasselby JP; Department of Pathology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark. |
| المصدر: | Pathology, research and practice [Pathol Res Pract] 2021 Apr; Vol. 220, pp. 153368. Date of Electronic Publication: 2021 Feb 08. |
| نوع المنشور: | Journal Article; Meta-Analysis; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 7806109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0631 (Electronic) Linking ISSN: 03440338 NLM ISO Abbreviation: Pathol Res Pract Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart : Gustav Fischer Verlag Original Publication: Stuttgart, New York, Fischer. |
| مواضيع طبية MeSH: | Endoscopic Ultrasound-Guided Fine Needle Aspiration*, Neoplasms, Cystic, Mucinous, and Serous/*pathology , Pancreatic Cyst/*pathology , Pancreatic Neoplasms/*pathology , Pancreatic Pseudocyst/*pathology, Aged ; Female ; Humans ; Male ; Middle Aged ; Neoplasms, Cystic, Mucinous, and Serous/surgery ; Pancreatic Cyst/surgery ; Pancreatic Neoplasms/surgery ; Pancreatic Pseudocyst/surgery ; Predictive Value of Tests ; Reproducibility of Results |
| مستخلص: | Objectives: To address the diagnostic accuracy of endoscopic ultrasound guided through-the-needle-biopsies (TTNBs) and simultaneously obtained cytology samples from pancreatic cysts compared to the final histopathological diagnosis of the surgical specimen, and to give an overview of ancillary tests performed on TTNBs. Methods: A literature search was conducted in MEDLINE, Embase and Scopus. Studies were included in the meta-analysis, if they had data for TTNB, cytology and a surgical specimen of pancreatic cysts as reference standard. The assessment of the risk of bias and quality of the included studies was conducted using the modified QUADAS-2 tool. Results: Ten studies with 99 patients were included in the meta-analysis. Data regarding study design and clinicopathological features were extracted systematically. For TTNB, pooled sensitivity was 0.86 (95 % CI 0.62-0.96), specificity 0.95 (95 % CI 0.79-0.99) and area under the curve (AUC) 0.86 for the diagnosis of a mucinous cyst and pooled sensitivity was 0.78 (95 % CI 0.61-0.89), specificity 0.99 (95 % CI 0.90-0.99) and AUC 0.92 for the diagnosis of a high-risk cyst. For a specific diagnosis, pooled sensitivity was 0.69 (95 % CI 0.50-0.83), specificity 0.47 (95 % CI 0.28-0.68) and AUC 0.49. For cytology performed simultaneously, pooled sensitivity was 0.46 (95 % CI 0.35-0.57), specificity 0.90 (95 % CI 0.46-0.99) and AUC 0.64 for the diagnosis of mucinous cysts, and pooled sensitivity was 0.38 (95 % CI 0.23-0.55), specificity 0.99 (95 % CI 0.90-0.99) and AUC 0.84 for the diagnosis of a high-risk cyst. For a specific diagnosis, pooled sensitivity was 0.29 (95 % CI 0.21-0.39), specificity 0.45 (95 % CI 0.25-0.66) and AUC 0.30. Furthermore, immunohistochemical stains can be useful to establish the specific cyst subtype. Conclusions: TTNBs have a higher sensitivity and specificity than cytology for the diagnosis of mucinous cyst and high- risk cysts of the pancreas. (Copyright © 2021 Elsevier GmbH. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cyst; Cytology; Diagnostic test; Meta-analysis; Pancreas; Through-the-needle-biopsy |
| تواريخ الأحداث: | Date Created: 20210302 Date Completed: 20211109 Latest Revision: 20211109 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.prp.2021.153368 |
| PMID: | 33652239 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1618-0631 |
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| DOI: | 10.1016/j.prp.2021.153368 |