دورية أكاديمية
أعرض في EDS

Magnetic resonance spectroscopy brain metabolites at term and 3-year neurodevelopmental outcomes in very preterm infants.

التفاصيل البيبلوغرافية
العنوان: Magnetic resonance spectroscopy brain metabolites at term and 3-year neurodevelopmental outcomes in very preterm infants.
المؤلفون: Illapani VSP; Division of Neonatology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Edmondson DA; Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Cecil KM; Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Altaye M; Division of Biostatistics and Epidemiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Kumar M; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health & Neurosciences (NIMHANS), Bengaluru, India., Harpster K; Division of Occupational Therapy and Physical Therapy, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Parikh NA; Division of Neonatology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Nehal.Parikh@cchmc.org.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Nehal.Parikh@cchmc.org.
المصدر: Pediatric research [Pediatr Res] 2022 Jul; Vol. 92 (1), pp. 299-306. Date of Electronic Publication: 2021 Mar 02.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2012- : New York : Nature Publishing Group
Original Publication: Basel ; New York : Karger.
مواضيع طبية MeSH: Creatine*/metabolism , Infant, Premature, Diseases*/pathology, Brain ; Child, Preschool ; Choline ; Female ; Fetal Growth Retardation/metabolism ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Magnetic Resonance Spectroscopy ; Prospective Studies
مستخلص: Background: Noninvasive advanced neuroimaging and neurochemical assessment can identify subtle abnormalities and predict neurodevelopmental impairments. Our objective was to quantify white matter metabolite levels and evaluate their relationship with neurodevelopmental outcomes at age 3 years.
Methods: Our study evaluated a longitudinal prospective cohort of very premature infants (<32 weeks gestational age) with single-voxel proton magnetic resonance spectroscopy from the centrum semiovale performed at term-equivalent age and standardized cognitive, verbal, and motor assessments at 3 years corrected age. We separately examined metabolite ratios in the left and right centrum semiovale. We also conducted an exploratory interaction analysis for high/low socioeconomic status (SES) to evaluate the relationship between metabolites and neurodevelopmental outcomes, after adjusting for confounders.
Results: We found significant relationships between choline/creatine levels in the left and right centrum semiovale and motor development scores. Exploratory interaction analyses revealed that, for infants with low SES, there was a negative association between choline/creatine in the left centrum semiovale and motor assessment scores at age 3 years.
Conclusions: Brain metabolites from the centrum semiovale at term-equivalent age were associated with motor outcomes for very preterm infants at 3 years corrected age. This effect may be most pronounced for infants with low SES.
Impact: Motor development at 3 years corrected age for very preterm infants is inversely associated with choline neurochemistry within the centrum semiovale on magnetic resonance spectroscopy at term-equivalent age, especially in infants with low socioeconomic status. No prior studies have studied metabolites in the centrum semiovale to predict neurodevelopmental outcomes at 3 years corrected age based on high/low socioeconomic status. For very preterm infants with lower socioeconomic status, higher choline-to-creatine ratio in central white matter is associated with worse neurodevelopmental outcomes.
(© 2021. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)
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معلومات مُعتمدة: R01 NS094200 United States NS NINDS NIH HHS; R01 ES026446 United States ES NIEHS NIH HHS; R21 HD094085 United States HD NICHD NIH HHS; R01 ES027224 United States ES NIEHS NIH HHS; R01 NS096037 United States NS NINDS NIH HHS; T32 ES010957 United States ES NIEHS NIH HHS
المشرفين على المادة: MU72812GK0 (Creatine)
N91BDP6H0X (Choline)
تواريخ الأحداث: Date Created: 20210303 Date Completed: 20220829 Latest Revision: 20230205
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8410891
DOI: 10.1038/s41390-021-01434-5
PMID: 33654289
قاعدة البيانات: MEDLINE
الوصف
تدمد:1530-0447
DOI:10.1038/s41390-021-01434-5