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The Relationship Between Plexin C1 Overexpression and Survival in Hepatocellular Carcinoma: a Turkish Oncology Group (TOG) Study.

التفاصيل البيبلوغرافية
العنوان: The Relationship Between Plexin C1 Overexpression and Survival in Hepatocellular Carcinoma: a Turkish Oncology Group (TOG) Study.
المؤلفون: NazimTurhal S; Department of Medical Oncology, Anadolu Medical Center, Istanbul, Turkey., Dogan M; Department of Medical Oncology, Ankara Oncology Training and Research Hospital, Ankara, Turkey. mutludogan1@yahoo.com., Esendagli G; Department of Pathology, Faculty of Medicine, Gazi University, Ankara, Turkey., Artac M; Department of Medical Oncology, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey., Korkmaz L; Department of Computer Engineering, Faculty of Engineering, Istinye University, Istanbul, Turkey., Coskun HS; Department of Medical Oncology, Akdeniz UniversityFaculty of Medicine, Antalya, Turkey., Goker E; Department of Medical Oncology, Ege UniversityFaculty of Medicine, Izmir, Turkey., PerranYumuk F; Department of Medical Oncology, Marmara UniversityFaculty of Medicine, Istanbul, Turkey., Bilgetekin I; Department of Medical Oncology, Ankara Oncology Training and Research Hospital, Ankara, Turkey., Kose F; Department of Medical Oncology, Faculty of Medicine, Baskent University, Adana, Turkey., Uncu D; Department of Medical Oncology, Ankara Numune Training and Research Hospital, Ankara, Turkey., Kavgaci H; Department of Medical Oncology, Faculty of Medicine, Karadeniz University, Trabzon, Turkey., Akyol G; Department of Pathology, Faculty of Medicine, Gazi University, Ankara, Turkey., Ozet A; Department of Medical Oncology, Faculty of Medicine, Gazi University, Ankara, Turkey., Yagci T; Department of Molecular Biology and Genetics, Faculty of Basic Sciences, Gebze Technical University, Kocaeli, Turkey.
المصدر: Journal of gastrointestinal cancer [J Gastrointest Cancer] 2022 Jun; Vol. 53 (2), pp. 356-362. Date of Electronic Publication: 2021 Mar 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Science+Business Media Country of Publication: United States NLM ID: 101479627 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-6636 (Electronic) NLM ISO Abbreviation: J Gastrointest Cancer Subsets: MEDLINE
أسماء مطبوعة: Publication: 2010- : New York : Springer Science+Business Media
Original Publication: New York, NY : Humana Press
مواضيع طبية MeSH: Carcinoma, Hepatocellular*/pathology , Liver Neoplasms*/pathology , Receptors, Virus*/genetics, Biomarkers, Tumor ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Turkey
مستخلص: Purpose: Plexin C1 is a transmembrane receptor and plexin C1 overexpression might have role in carcinogenesis. Hepatocellular carcinoma (HCC) has poor prognosis because of its aggressive behavior and limited treatment options, especially in advanced stage. We recently documented that Plexin C1 was overexpressed in HCC. We aimed to evaluate the prognostic significance of Plexin C1 overexpression in HCC in the present study.
Methods: Plexin C1 overexpression was evaluated immunohistochemically on paraffin-embedded blocks of the HCC patients. Plexin C1 immunohistochemical staining was scored. Plexin C1 overexpression staining intensity and prevalence were used for plexin scale staining evaluation and plexin scores were estimated according this staining scale. Plexin C1 score and its association with survival and clinicopathological features was assessed.
Results: Sixty-seven HCC patients with adequate tissue for pathological evaluation were included. Median age was 63 years with male predominance (male to female ratio was 4.75 (n 57/12). Well-differentiated HCC (53.7%) patients had higher plexin C1 overexpression (p < 0.05). Median OS was 22.1 months. Patients with lower plexin C1 score (< 12) had shorter OS (17.5 vs 30.1 months, p = 0.036). Neutrophil count, GGT, and PNR (platelet/neutrophil ratio) had prognostic significance (p = 0.047, p = 0.018, and p = 0.045).
Conclusion: Plexin C1 overexpression is inversely correlated with grade in HCC. The patients with lower rate of Plexin C1 overexpression have worse survival outcome. It might be a prognostic factor in HCC.
(© 2021. Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Hcc; Hepatocellular carcinoma; Plexin
المشرفين على المادة: 0 (Biomarkers, Tumor)
0 (Receptors, Virus)
0 (VESPR semaphorin receptor)
تواريخ الأحداث: Date Created: 20210303 Date Completed: 20220609 Latest Revision: 20220613
رمز التحديث: 20231215
DOI: 10.1007/s12029-021-00602-4
PMID: 33656690
قاعدة البيانات: MEDLINE
الوصف
تدمد:1941-6636
DOI:10.1007/s12029-021-00602-4