دورية أكاديمية
Long-term evolution and short-term adaptation of microbiota strains and sub-strains in mice.
| العنوان: | Long-term evolution and short-term adaptation of microbiota strains and sub-strains in mice. |
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| المؤلفون: | Yilmaz B; Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, 3008 Bern, Switzerland; Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, 3008 Bern, Switzerland., Mooser C; Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, 3008 Bern, Switzerland; Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, 3008 Bern, Switzerland., Keller I; Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, 3008 Bern, Switzerland; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics, University of Bern, Bern, 3012, Switzerland., Li H; Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, 3008 Bern, Switzerland; Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, 3008 Bern, Switzerland., Zimmermann J; Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, 3008 Bern, Switzerland; Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, 3008 Bern, Switzerland., Bosshard L; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics, University of Bern, Bern, 3012, Switzerland; CMPG, Institute of Ecology and Evolution, University of Bern, 3012 Bern, Switzerland., Fuhrer T; Institute of Molecular Systems Biology, Swiss Federal Institute of Technology (ETH) Zürich, 8093 Zürich, Switzerland., Gomez de Agüero M; Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, 3008 Bern, Switzerland; Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, 3008 Bern, Switzerland., Trigo NF; Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, 3008 Bern, Switzerland; Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, 3008 Bern, Switzerland., Tschanz-Lischer H; Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, 3008 Bern, Switzerland; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics, University of Bern, Bern, 3012, Switzerland., Limenitakis JP; Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, 3008 Bern, Switzerland; Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, 3008 Bern, Switzerland., Hardt WD; Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland., McCoy KD; Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, 3008 Bern, Switzerland; Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, 3008 Bern, Switzerland., Stecher B; Max-von-Pettenkofer Institute, LMU Munich, 80336 Munich, Germany; German Center for Infection Research (DZIF), partner site LMU Munich, 80539 Munich, Germany., Excoffier L; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics, University of Bern, Bern, 3012, Switzerland; CMPG, Institute of Ecology and Evolution, University of Bern, 3012 Bern, Switzerland., Sauer U; Institute of Molecular Systems Biology, Swiss Federal Institute of Technology (ETH) Zürich, 8093 Zürich, Switzerland., Ganal-Vonarburg SC; Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, 3008 Bern, Switzerland; Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, 3008 Bern, Switzerland., Macpherson AJ; Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, 3008 Bern, Switzerland; Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, 3008 Bern, Switzerland. Electronic address: andrew.macpherson@dbmr.unibe.ch. |
| المصدر: | Cell host & microbe [Cell Host Microbe] 2021 Apr 14; Vol. 29 (4), pp. 650-663.e9. Date of Electronic Publication: 2021 Mar 03. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, Mass. : Cell Press |
| مواضيع طبية MeSH: | Adaptation, Physiological*/immunology, Gastrointestinal Microbiome/*physiology , Microbiota/*physiology, Animals ; Bacteria/genetics ; Female ; Gastrointestinal Microbiome/genetics ; Gastrointestinal Microbiome/immunology ; Genomics ; Immunity ; Intestines ; Male ; Metabolomics ; Mice ; Mice, Inbred C57BL ; Ralstonia ; Symbiosis |
| مستخلص: | Isobiotic mice, with an identical stable microbiota composition, potentially allow models of host-microbial mutualism to be studied over time and between different laboratories. To understand microbiota evolution in these models, we carried out a 6-year experiment in mice colonized with 12 representative taxa. Increased non-synonymous to synonymous mutation rates indicate positive selection in multiple taxa, particularly for genes annotated for nutrient acquisition or replication. Microbial sub-strains that evolved within a single taxon can stably coexist, consistent with niche partitioning of ecotypes in the complex intestinal environment. Dietary shifts trigger rapid transcriptional adaptation to macronutrient and micronutrient changes in individual taxa and alterations in taxa biomass. The proportions of different sub-strains are also rapidly altered after dietary shift. This indicates that microbial taxa within a mouse colony adapt to changes in the intestinal environment by long-term genomic positive selection and short-term effects of transcriptional reprogramming and adjustments in sub-strain proportions. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: Cell Host Microbe. 2021 Apr 14;29(4):545-547. (PMID: 33857417) |
| فهرسة مساهمة: | Keywords: dietary shifts; microbiota evolution; niche partitioning; stable animal model; sub-strains |
| تواريخ الأحداث: | Date Created: 20210304 Date Completed: 20211004 Latest Revision: 20211004 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.chom.2021.02.001 |
| PMID: | 33662276 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1934-6069 |
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| DOI: | 10.1016/j.chom.2021.02.001 |