دورية أكاديمية
أعرض في EDS

The effects of ductal size on the severity of pulmonary hypertension in children with patent ductus arteriosus (PDA): a multi-center study.

التفاصيل البيبلوغرافية
العنوان: The effects of ductal size on the severity of pulmonary hypertension in children with patent ductus arteriosus (PDA): a multi-center study.
المؤلفون: Chinawa JM; Pediatric Cardiologist, College of Medicine, Department of Pediatrics, University of Nigeria/University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, Enugu State, Nigeria. josephat.chinawa@unn.edu.ng., Chukwu BF; Department of Pediatrics, University of Nigeria/University of Nigeria Teaching Hospital (UNTH), Enugu State, Ituku-Ozalla, Nigeria., Chinawa AT; Enugu State University Teaching Hospital, Enugu, Enugu State, Nigeria., Duru CO; Department of Paediatrics and Child Health, Niger Delta University Teaching Hospital, Okolobiri, Bayelsa State, Nigeria.
المصدر: BMC pulmonary medicine [BMC Pulm Med] 2021 Mar 05; Vol. 21 (1), pp. 79. Date of Electronic Publication: 2021 Mar 05.
نوع المنشور: Journal Article; Multicenter Study; Observational Study
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968563 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2466 (Electronic) Linking ISSN: 14712466 NLM ISO Abbreviation: BMC Pulm Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001]-
مواضيع طبية MeSH: Ductus Arteriosus/*pathology , Ductus Arteriosus, Patent/*complications , Ductus Arteriosus, Patent/*pathology , Hypertension, Pulmonary/*complications, Adolescent ; Child ; Child, Preschool ; Cross-Sectional Studies ; Ductus Arteriosus/diagnostic imaging ; Echocardiography ; Female ; Humans ; Infant ; Male ; Nigeria ; Severity of Illness Index
مستخلص: Introduction: Patent ductus arteriosus (PDA) is a common acyanotic heart disease that presents with variable symptoms.
Objectives: This study is therefore aimed at determining the relationship between gender, age, and size of PDA and pulmonary hypertension. This study also seeks to determine the prevalence of elevated pulmonary artery systolic pressure in children with PDA.
Patients and Methods: A descriptive study of children with patent ductus arteriosus was carried out from 2016 to 2020 in three institutions. The data were analysed with the IBM SPSS statistics for windows, version 20 (IBM Corp, Chicago) RESULT: The mean ductal size was 3.78 (2.39) mm, with a minimum of 1.0 mm and a maximum size of 10.0 mm. The mean ductal size for males, 4.02 (2.53) mm was comparable with that of the females, 3.61 (2.28) mm (Student T-test = 0.8, 0.4). The mean pulmonary artery systolic pressure (PASP) of the patients was 43.36 (24.46) mmHg. Also the mean PASP was comparable among the males and the females, 48.37 (26.69) mmHg versus 39.63 (22.16) mmHg (Student T-test = 1.81, p = 0.07). There was no correlation between age and PASP (correlation coefficient = 0.009, p = 0.92). Sixty point two percent (60.2%) (62/103) of children with PDA had pulmonary hypertension. The proportion of males with pulmonary hypertension, 48.39% (30/62) was comparable with that of the females, 51.61% (32/62) (Chi 2  = 2.05, p = 0.15) and females are 1.8 times more likely to have pulmonary hypertension as males (odds ratio 1.81, 95% CI 0.8-4.1). There was a positive correlation between ductal size and PASP (Pearson correlation coefficient = 0.26, p value = 0.007). Those with moderate and large sized duct tend to have moderate and severe pulmonary hypertension respectively and this is statistically significant. Chi 2  = 17.85, p = 0.007 CONCLUSION: The prevalence of pulmonary hypertension in children with PDA is 60.2%. Moderate and large size duct presents with moderate and severe pulmonary hypertension respectively. Females are 1.8 times more likely to have pulmonary hypertension than the males.
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فهرسة مساهمة: Keywords: Children; Ductal size; PDA; Pulmonary hypertension
تواريخ الأحداث: Date Created: 20210305 Date Completed: 20211011 Latest Revision: 20240807
رمز التحديث: 20240807
مُعرف محوري في PubMed: PMC7934417
DOI: 10.1186/s12890-021-01449-y
PMID: 33663433
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2466
DOI:10.1186/s12890-021-01449-y