دورية أكاديمية
Nanotherapeutic approach to treat diabetic foot ulcers using tissue-engineered nanofiber skin substitutes: A review.
| العنوان: | Nanotherapeutic approach to treat diabetic foot ulcers using tissue-engineered nanofiber skin substitutes: A review. |
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| المؤلفون: | Bahmad HF; Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, USA. Electronic address: Hisham.Bahmad@msmc.com., Poppiti R; Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, USA; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA., Alexis J; Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, USA; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA. |
| المصدر: | Diabetes & metabolic syndrome [Diabetes Metab Syndr] 2021 Mar-Apr; Vol. 15 (2), pp. 487-491. Date of Electronic Publication: 2021 Feb 23. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Ltd Country of Publication: Netherlands NLM ID: 101462250 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0334 (Electronic) Linking ISSN: 18714021 NLM ISO Abbreviation: Diabetes Metab Syndr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Ltd. |
| مواضيع طبية MeSH: | Skin, Artificial*, Diabetes Mellitus/*therapy , Diabetic Foot/*therapy , Nanotechnology/*methods , Tissue Engineering/*methods, Diabetes Mellitus/diagnosis ; Diabetes Mellitus/metabolism ; Diabetic Foot/diagnosis ; Diabetic Foot/metabolism ; Humans ; Nanotechnology/trends ; Tissue Engineering/trends ; Treatment Outcome ; Wound Healing/physiology |
| مستخلص: | Background and Aims: Diabetes mellitus (DM) is a chronic metabolic disease associated with long-term multisystem complications, among which nonhealing diabetic foot ulcers (DFUs) are recognized as major cause of morbidity and mortality. Treating DFUs with surgical procedures such as synthetic or biological skin grafts or skin substitutes has several limitations, where none of the currently available skin substitutes is ideal. Methods: OVID/Medline and PubMed databases were searched using the Medical Subject Heading (MeSH) or Title/Abstract words ("diabetic foot ulcers", "skin substitutes", and "nanofibers"), to identify published research studies on DFUs and nanofibers. Results: Electrospinning nanotechnology is being used in the biomedical field to produce polymeric nanofibers impregnated with drugs for wound healing, burns and diabetic ulcers. Those nanofibers also enable seeding of cells into them and culturing them in vitro to synthesize tissue-like structures. Knowing the advantages of generating patient-specific induced pluripotent stem cells (iPSCs) and organoids in three-dimension (3D), including skin organoids, it is worth mingling these technologies to develop tissue-engineered biological skin substitutes. Conclusion: Nanofiber-skin substitutes hold promise for treatment of patients suffering from DFUs and inspire novel strategies that could be applied to other organ systems as well, introducing a new era of "regenerative and personalized medicine". Competing Interests: Declaration of competing interest None. (Copyright © 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Diabetes mellitus; Diabetic foot ulcers; Nanofibers; Skin substitutes |
| تواريخ الأحداث: | Date Created: 20210305 Date Completed: 20211111 Latest Revision: 20211111 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.dsx.2021.02.025 |
| PMID: | 33668000 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1878-0334 |
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| DOI: | 10.1016/j.dsx.2021.02.025 |