دورية أكاديمية
أعرض في EDS

Hypothiocyanite and Hypothiocyanite/Lactoferrin Mixture Exhibit Virucidal Activity In Vitro against SARS-CoV-2.

التفاصيل البيبلوغرافية
العنوان: Hypothiocyanite and Hypothiocyanite/Lactoferrin Mixture Exhibit Virucidal Activity In Vitro against SARS-CoV-2.
المؤلفون: Cegolon L; Public Health Department, Local Health Unit N.2 'Marca Trevigiana', 31100 Treviso, Italy., Mirandola M; Department of Molecular Medicine, University of Padova, 35121 Padova, Italy., Salaris C; Department of Molecular Medicine, University of Padova, 35121 Padova, Italy., Salvati MV; Department of Molecular Medicine, University of Padova, 35121 Padova, Italy., Mastrangelo G; Department of Cardiac, Thoracic, Vascular Sciences & Public Health, University of Padova, 35121 Padova, Italy., Salata C; Department of Molecular Medicine, University of Padova, 35121 Padova, Italy.
المصدر: Pathogens (Basel, Switzerland) [Pathogens] 2021 Feb 19; Vol. 10 (2). Date of Electronic Publication: 2021 Feb 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Print ISSN: 2076-0817 (Print) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2012-
مستخلص: SARS-CoV-2 replicates efficiently in the upper airways during the prodromal stage, resulting in environmental viral shedding from patients with active COVID-19 as well as from asymptomatic individuals. There is a need to find pharmacological interventions to mitigate the spread of COVID-19. Hypothiocyanite and lactoferrin are molecules of the innate immune system with a large spectrum cidal activity. The Food and Drug Administration and the European Medicines Agency designated the hypothiocyanite and lactoferrin combination as an orphan drug. We report an in vitro study showing that micromolar concentrations of hypothiocyanite exhibit dose- and time-dependent virucidal activity against SARS-CoV-2 and that the latter is slightly enhanced by the simultaneous presence of lactoferrin.
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معلومات مُعتمدة: DOR-2019 and DOR-2020 Università degli Studi di Padova
فهرسة مساهمة: Keywords: ALX-009; COVID-19; SARS-CoV-2; hypothiocyanite; lactoferrin; lactoperoxidase system
تواريخ الأحداث: Date Created: 20210306 Latest Revision: 20210316
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7922920
DOI: 10.3390/pathogens10020233
PMID: 33669635
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-0817
DOI:10.3390/pathogens10020233