دورية أكاديمية
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Elevated Trehalose Levels in C. elegans daf-2 Mutants Increase Stress Resistance, Not Lifespan.

التفاصيل البيبلوغرافية
العنوان: Elevated Trehalose Levels in C. elegans daf-2 Mutants Increase Stress Resistance, Not Lifespan.
المؤلفون: Rasulova M; Laboratory of Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium., Zečić A; Laboratory of Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium., Monje Moreno JM; Laboratory of Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium., Vandemeulebroucke L; Laboratory of Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium., Dhondt I; Laboratory of Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium., Braeckman BP; Laboratory of Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium.
المصدر: Metabolites [Metabolites] 2021 Feb 12; Vol. 11 (2). Date of Electronic Publication: 2021 Feb 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101578790 Publication Model: Electronic Cited Medium: Print ISSN: 2218-1989 (Print) Linking ISSN: 22181989 NLM ISO Abbreviation: Metabolites Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مستخلص: The C. elegans insulin/IGF-1 (insulin-like growth factor 1) signaling mutant daf-2 recapitulates the dauer metabolic signature-a shift towards lipid and carbohydrate accumulation-which may be linked to its longevity and stress resistance phenotypes. Trehalose, a disaccharide of glucose, is highly upregulated in daf‑2 mutants and it has been linked to proteome stabilization and protection against heat, cold, desiccation, and hypoxia. Earlier studies suggested that elevated trehalose levels can explain up to 43% of the lifespan extension observed in daf-2 mutants. Here we demonstrate that trehalose accumulation is responsible for increased osmotolerance, and to some degree thermotolerance, rather than longevity in daf-2 mutants. This indicates that particular stress resistance phenotypes can be uncoupled from longevity.
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معلومات مُعتمدة: P40 OD010440 United States OD NIH HHS; 11E6415N and G.0D64.14N Fonds Wetenschappelijk Onderzoek; BOF15/24j/013 Bijzonder Onderzoeksfonds UGent
فهرسة مساهمة: Keywords: Caenorhabditis elegans; glucose; glycogen; lifespan; maltose; trehalose; trehalose 6-phosphate synthase
تواريخ الأحداث: Date Created: 20210306 Latest Revision: 20210316
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7917784
DOI: 10.3390/metabo11020105
PMID: 33673074
قاعدة البيانات: MEDLINE
الوصف
تدمد:2218-1989
DOI:10.3390/metabo11020105