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ImmuneDEX: a strategy for the genetic improvement of immune competence in Australian Angus cattle.

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العنوان: ImmuneDEX: a strategy for the genetic improvement of immune competence in Australian Angus cattle.
المؤلفون: Reverter A; CSIRO Agriculture & Food, Queensland Bioscience Precinct, St. Lucia, Brisbane, QLD, Australia., Hine BC; CSIRO Agriculture & Food, F.D. McMaster Laboratory, Chiswick, New England Highway, Armidale, NSW, Australia., Porto-Neto L; CSIRO Agriculture & Food, Queensland Bioscience Precinct, St. Lucia, Brisbane, QLD, Australia., Li Y; CSIRO Agriculture & Food, Queensland Bioscience Precinct, St. Lucia, Brisbane, QLD, Australia., Duff CJ; Angus Australia, Armidale, NSW, Australia., Dominik S; CSIRO Agriculture & Food, F.D. McMaster Laboratory, Chiswick, New England Highway, Armidale, NSW, Australia., Ingham AB; CSIRO Agriculture & Food, Queensland Bioscience Precinct, St. Lucia, Brisbane, QLD, Australia.
المصدر: Journal of animal science [J Anim Sci] 2021 Mar 01; Vol. 99 (3).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Society of Animal Science Country of Publication: United States NLM ID: 8003002 Publication Model: Print Cited Medium: Internet ISSN: 1525-3163 (Electronic) Linking ISSN: 00218812 NLM ISO Abbreviation: J Anim Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Champaign, IL : American Society of Animal Science
مواضيع طبية MeSH: Fertility*/genetics , Meat*, Animals ; Australia ; Body Composition/genetics ; Cattle/genetics ; Female ; Phenotype ; Weaning
مستخلص: In animal breeding and genetics, the ability to cope with disease, here defined as immune competence (IC), with minimal detriment to growth and fertility is a desired objective which addresses both animal production and welfare considerations. However, defining and objectively measuring IC phenotypes using testing methods which are practical to apply on-farm has been challenging. Based on previously described protocols, we measured both cell-mediated immune response (Cell-IR) and antibody-mediated immune response (Ab-IR) and combined these measures to determine an animal's IC. Using a population of 2,853 Australian Angus steers and heifers, we compared 2 alternative methods to combine both metrics into a single phenotype to be used as a tool for the genetic improvement of IC. The first method, named ZMEAN, is obtained by taking the average of the individual metrics after subjecting each to a Z-score standardization. The second, ImmuneDEX (IDEX), is a weighted average that considers the correlation between Cell-IR and Ab-IR, as well as the difference in ranking of individuals by each metric, and uses these as weights in the averaging. Both simulation and real data were used to understand the behavior of ZMEAN and IDEX. To further ascertain the relationship between IDEX and other traits of economic importance, we evaluated a range of traits related to growth, feedlot performance, and carcass characteristics. We report estimates of heritability of 0.31 ± 0.06 for Cell-IR, 0.42 ± 0.06 for Ab-IR, 0.42 ± 0.06 for ZMEAN and 0.370 ± 0.06 for IDEX, as well as a unity genetic correlation (rg) between ZMEAN and IDEX. While a moderately positive rg was estimated between Cell-IR and Ab-IR (rg = 0.33 ± 0.12), strongly positive estimates were obtained between IDEX and Cell-IR (rg = 0.80 ± 0.05) and between IDEX and Ab-IR (rg = 0.85 ± 0.04). We obtained a moderately negative rg between IC traits and growth including an rg = -0.38 ± 0.14 between IDEX and weaning weight, and negligible with carcass fat measurements, including an rg = -0.03 ± 0.12 between IDEX and marbling. Given that breeding with a sole focus on production might inadvertently increase susceptibility to disease and associated antibiotic use, our analyses suggest that ImmuneDEX will provide a basis to breed animals that are both highly productive and with an enhanced ability to resist disease.
(© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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فهرسة مساهمة: Keywords: beef cattle; heritability; immune competence; stress; weaning
تواريخ الأحداث: Date Created: 20210307 Date Completed: 20210310 Latest Revision: 20220304
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7936916
DOI: 10.1093/jas/skaa384
PMID: 33677583
قاعدة البيانات: MEDLINE
الوصف
تدمد:1525-3163
DOI:10.1093/jas/skaa384