دورية أكاديمية
أعرض في EDS

Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor.

التفاصيل البيبلوغرافية
العنوان: Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor.
المؤلفون: Sim CB; Murdoch Children's Research Institute (C.B.S., B.P., K.D.A.-B., R.K.R.K., H.K.V., M.t.H., C.J.V., A.H., A.T.P., I.E.K., D.A.E., A.O., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (C.B.S., K.D.A.-B., R.K.R.K., M.t.H., C.J.V., L.M.D.D., A.T.P., I.E.K., D.A.E., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia., Phipson B; Murdoch Children's Research Institute (C.B.S., B.P., K.D.A.-B., R.K.R.K., H.K.V., M.t.H., C.J.V., A.H., A.T.P., I.E.K., D.A.E., A.O., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; Peter MacCallum Cancer Centre (B.P., A.O.), University of Melbourne, Victoria, Australia., Ziemann M; Department of Diabetes, Central Clinical School, Alfred Centre, Monash University, Melbourne, Victoria, Australia (M.Z., H.R., A.K., H.K., A.E.-O.).; School of Life and Environmental Sciences, Deakin University, Waurn Ponds, Victoria, Australia (M.Z.).; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (M.Z., H.R., K.I.W., A.K., H.K., P.G., A.E.-O.)., Rafehi H; Department of Diabetes, Central Clinical School, Alfred Centre, Monash University, Melbourne, Victoria, Australia (M.Z., H.R., A.K., H.K., A.E.-O.).; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (M.Z., H.R., K.I.W., A.K., H.K., P.G., A.E.-O.)., Mills RJ; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia (R.J.M., J.E.H.)., Watt KI; Peter MacCallum Cancer Centre (B.P., A.O.), University of Melbourne, Victoria, Australia.; Centre for Muscle Research (K.I.W., P.G., E.R.P.), University of Melbourne, Victoria, Australia.; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (M.Z., H.R., K.I.W., A.K., H.K., P.G., A.E.-O.)., Abu-Bonsrah KD; Murdoch Children's Research Institute (C.B.S., B.P., K.D.A.-B., R.K.R.K., H.K.V., M.t.H., C.J.V., A.H., A.T.P., I.E.K., D.A.E., A.O., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (C.B.S., K.D.A.-B., R.K.R.K., M.t.H., C.J.V., L.M.D.D., A.T.P., I.E.K., D.A.E., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; School of Biomedical Sciences, and Department of Paediatrics (K.D.A.-B., H.K.V., A.H., I.E.K., D.A.E.), University of Melbourne, Victoria, Australia., Kalathur RKR; Murdoch Children's Research Institute (C.B.S., B.P., K.D.A.-B., R.K.R.K., H.K.V., M.t.H., C.J.V., A.H., A.T.P., I.E.K., D.A.E., A.O., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (C.B.S., K.D.A.-B., R.K.R.K., M.t.H., C.J.V., L.M.D.D., A.T.P., I.E.K., D.A.E., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia., Voges HK; Murdoch Children's Research Institute (C.B.S., B.P., K.D.A.-B., R.K.R.K., H.K.V., M.t.H., C.J.V., A.H., A.T.P., I.E.K., D.A.E., A.O., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; School of Biomedical Sciences, and Department of Paediatrics (K.D.A.-B., H.K.V., A.H., I.E.K., D.A.E.), University of Melbourne, Victoria, Australia., Dinh DT; Robinson Research Institute, The University of Adelaide, South Australia, Australia (D.T.D., R.L.R.)., Ter Huurne M; Murdoch Children's Research Institute (C.B.S., B.P., K.D.A.-B., R.K.R.K., H.K.V., M.t.H., C.J.V., A.H., A.T.P., I.E.K., D.A.E., A.O., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (C.B.S., K.D.A.-B., R.K.R.K., M.t.H., C.J.V., L.M.D.D., A.T.P., I.E.K., D.A.E., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia., Vivien CJ; Murdoch Children's Research Institute (C.B.S., B.P., K.D.A.-B., R.K.R.K., H.K.V., M.t.H., C.J.V., A.H., A.T.P., I.E.K., D.A.E., A.O., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (C.B.S., K.D.A.-B., R.K.R.K., M.t.H., C.J.V., L.M.D.D., A.T.P., I.E.K., D.A.E., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia., Kaspi A; Department of Diabetes, Central Clinical School, Alfred Centre, Monash University, Melbourne, Victoria, Australia (M.Z., H.R., A.K., H.K., A.E.-O.).; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (M.Z., H.R., K.I.W., A.K., H.K., P.G., A.E.-O.)., Kaipananickal H; Department of Diabetes, Central Clinical School, Alfred Centre, Monash University, Melbourne, Victoria, Australia (M.Z., H.R., A.K., H.K., A.E.-O.).; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (M.Z., H.R., K.I.W., A.K., H.K., P.G., A.E.-O.)., Hidalgo A; Murdoch Children's Research Institute (C.B.S., B.P., K.D.A.-B., R.K.R.K., H.K.V., M.t.H., C.J.V., A.H., A.T.P., I.E.K., D.A.E., A.O., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; School of Biomedical Sciences, and Department of Paediatrics (K.D.A.-B., H.K.V., A.H., I.E.K., D.A.E.), University of Melbourne, Victoria, Australia., Delbridge LMD; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (C.B.S., K.D.A.-B., R.K.R.K., M.t.H., C.J.V., L.M.D.D., A.T.P., I.E.K., D.A.E., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; Department of Anatomy and Physiology (K.I.W., L.M.D.D., P.G., E.R.P.), University of Melbourne, Victoria, Australia., Robker RL; Robinson Research Institute, The University of Adelaide, South Australia, Australia (D.T.D., R.L.R.)., Gregorevic P; Department of Anatomy and Physiology (K.I.W., L.M.D.D., P.G., E.R.P.), University of Melbourne, Victoria, Australia.; Centre for Muscle Research (K.I.W., P.G., E.R.P.), University of Melbourne, Victoria, Australia.; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (M.Z., H.R., K.I.W., A.K., H.K., P.G., A.E.-O.)., Dos Remedios CG; School of Medical Sciences, The University of Sydney, New South Wales, Australia (C.G.d.R., S.L.).; Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia (C.G.d.R.)., Lal S; School of Medical Sciences, The University of Sydney, New South Wales, Australia (C.G.d.R., S.L.)., Piers AT; Murdoch Children's Research Institute (C.B.S., B.P., K.D.A.-B., R.K.R.K., H.K.V., M.t.H., C.J.V., A.H., A.T.P., I.E.K., D.A.E., A.O., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (C.B.S., K.D.A.-B., R.K.R.K., M.t.H., C.J.V., L.M.D.D., A.T.P., I.E.K., D.A.E., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia., Konstantinov IE; Murdoch Children's Research Institute (C.B.S., B.P., K.D.A.-B., R.K.R.K., H.K.V., M.t.H., C.J.V., A.H., A.T.P., I.E.K., D.A.E., A.O., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (C.B.S., K.D.A.-B., R.K.R.K., M.t.H., C.J.V., L.M.D.D., A.T.P., I.E.K., D.A.E., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; Department of Cardiac Surgery (I.E.K.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; School of Biomedical Sciences, and Department of Paediatrics (K.D.A.-B., H.K.V., A.H., I.E.K., D.A.E.), University of Melbourne, Victoria, Australia., Elliott DA; Murdoch Children's Research Institute (C.B.S., B.P., K.D.A.-B., R.K.R.K., H.K.V., M.t.H., C.J.V., A.H., A.T.P., I.E.K., D.A.E., A.O., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (C.B.S., K.D.A.-B., R.K.R.K., M.t.H., C.J.V., L.M.D.D., A.T.P., I.E.K., D.A.E., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; School of Biomedical Sciences, and Department of Paediatrics (K.D.A.-B., H.K.V., A.H., I.E.K., D.A.E.), University of Melbourne, Victoria, Australia., El-Osta A; Murdoch Children's Research Institute (C.B.S., B.P., K.D.A.-B., R.K.R.K., H.K.V., M.t.H., C.J.V., A.H., A.T.P., I.E.K., D.A.E., A.O., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia., Oshlack A; Department of Diabetes, Central Clinical School, Alfred Centre, Monash University, Melbourne, Victoria, Australia (M.Z., H.R., A.K., H.K., A.E.-O.).; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (M.Z., H.R., K.I.W., A.K., H.K., P.G., A.E.-O.).; Hong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital, Li Ka Shing Institute of Health Sciences, and The Chinese University of Hong Kong, China (A.E.-O.)., Hudson JE; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia (R.J.M., J.E.H.).; Centre for Cardiac and Vascular Biology, School of Biomedical Sciences, The University of Queensland, Brisbane, Australia (J.E.H., E.R.P.)., Porrello ER; Murdoch Children's Research Institute (C.B.S., B.P., K.D.A.-B., R.K.R.K., H.K.V., M.t.H., C.J.V., A.H., A.T.P., I.E.K., D.A.E., A.O., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (C.B.S., K.D.A.-B., R.K.R.K., M.t.H., C.J.V., L.M.D.D., A.T.P., I.E.K., D.A.E., E.R.P.), The Royal Children's Hospital, Melbourne, Victoria, Australia.; Department of Anatomy and Physiology (K.I.W., L.M.D.D., P.G., E.R.P.), University of Melbourne, Victoria, Australia.; Centre for Muscle Research (K.I.W., P.G., E.R.P.), University of Melbourne, Victoria, Australia.; Centre for Cardiac and Vascular Biology, School of Biomedical Sciences, The University of Queensland, Brisbane, Australia (J.E.H., E.R.P.).
المصدر: Circulation [Circulation] 2021 Apr 20; Vol. 143 (16), pp. 1614-1628. Date of Electronic Publication: 2021 Mar 08.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE
أسماء مطبوعة: Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: [Dallas, Tex., etc., American Heart Association, etc.]
مواضيع طبية MeSH: Heart/*physiopathology , Receptors, Progesterone/*metabolism, Female ; Humans ; Male ; Sex Factors
مستخلص: Background: Despite in-depth knowledge of the molecular mechanisms controlling embryonic heart development, little is known about the signals governing postnatal maturation of the human heart.
Methods: Single-nucleus RNA sequencing of 54 140 nuclei from 9 human donors was used to profile transcriptional changes in diverse cardiac cell types during maturation from fetal stages to adulthood. Bulk RNA sequencing and the Assay for Transposase-Accessible Chromatin using sequencing were used to further validate transcriptional changes and to profile alterations in the chromatin accessibility landscape in purified cardiomyocyte nuclei from 21 human donors. Functional validation studies of sex steroids implicated in cardiac maturation were performed in human pluripotent stem cell-derived cardiac organoids and mice.
Results: Our data identify the progesterone receptor as a key mediator of sex-dependent transcriptional programs during cardiomyocyte maturation. Functional validation studies in human cardiac organoids and mice demonstrate that the progesterone receptor drives sex-specific metabolic programs and maturation of cardiac contractile properties.
Conclusions: These data provide a blueprint for understanding human heart maturation in both sexes and reveal an important role for the progesterone receptor in human heart development.
التعليقات: Comment in: Nat Rev Cardiol. 2021 Jun;18(6):387. (PMID: 33742184)
References: J Biol Chem. 1984 May 25;259(10):6437-46. (PMID: 6327679)
Fertil Steril. 2004 Aug;82(2):430-6. (PMID: 15302294)
Science. 2019 Jul 19;365(6450):. (PMID: 31320509)
Genome Res. 2003 Nov;13(11):2498-504. (PMID: 14597658)
Circ Cardiovasc Qual Outcomes. 2018 Feb;11(2):e004437. (PMID: 29449443)
J Appl Physiol (1985). 2012 May;112(9):1564-75. (PMID: 22345431)
Bioinformatics. 2009 Jul 15;25(14):1754-60. (PMID: 19451168)
Card Fail Rev. 2017 Apr;3(1):7-11. (PMID: 28785469)
Nat Commun. 2018 Jan 26;9(1):391. (PMID: 29374152)
Development. 2017 Mar 15;144(6):1118-1127. (PMID: 28174241)
Bioinformatics. 2014 Apr 1;30(7):923-30. (PMID: 24227677)
Nat Commun. 2018 Apr 10;9(1):1373. (PMID: 29636455)
Circulation. 2017 Sep 19;136(12):1123-1139. (PMID: 28733351)
Nucleic Acids Res. 2016 Jul 8;44(W1):W160-5. (PMID: 27079975)
BMC Genomics. 2020 Jun 29;21(1):447. (PMID: 32600408)
Gigascience. 2018 Jul 1;7(7):. (PMID: 30010766)
Circ Res. 2020 Apr 10;126(8):1086-1106. (PMID: 32271675)
BMC Bioinformatics. 2014 Aug 29;15:293. (PMID: 25176396)
Cardiovasc Res. 2021 Aug 29;117(10):2252-2262. (PMID: 32941598)
J Vis Exp. 2012 Jul 10;(65):. (PMID: 22805241)
Circulation. 2020 Oct 13;142(15):1448-1463. (PMID: 32795101)
Cell Stem Cell. 2019 Jun 6;24(6):895-907.e6. (PMID: 30930147)
Nat Commun. 2014 Oct 22;5:5288. (PMID: 25335909)
BMC Bioinformatics. 2014 Jun 12;15:182. (PMID: 24925680)
Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1446-51. (PMID: 23302686)
Dev Cell. 2016 Nov 21;39(4):491-507. (PMID: 27840109)
Genome Biol. 2019 Dec 23;20(1):296. (PMID: 31870423)
Nucleic Acids Res. 2015 Apr 20;43(7):e47. (PMID: 25605792)
Development. 2020 Nov 30;147(22):. (PMID: 33144401)
Trends Endocrinol Metab. 2018 Jul;29(7):481-491. (PMID: 29705365)
Genes Dev. 2018 Oct 1;32(19-20):1344-1357. (PMID: 30254108)
Dev Cell. 2016 Nov 21;39(4):480-490. (PMID: 27840107)
Ann Appl Stat. 2016 Jun;10(2):946-963. (PMID: 28367255)
Physiol Rev. 2017 Jan;97(1):1-37. (PMID: 27807199)
Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8372-E8381. (PMID: 28916735)
Nat Methods. 2011 Oct 23;8(12):1037-40. (PMID: 22020065)
Curr Protoc Mol Biol. 2015 Jan 05;109:21.29.1-21.29.9. (PMID: 25559105)
Circ Heart Fail. 2012 Jul 1;5(4):523-34. (PMID: 22705768)
Nat Biotechnol. 2018 Jun;36(5):411-420. (PMID: 29608179)
NPJ Regen Med. 2016 Jul 28;1:16012. (PMID: 29302337)
Bioinformatics. 2010 Jan 1;26(1):139-40. (PMID: 19910308)
Nat Commun. 2020 Jun 2;11(1):2843. (PMID: 32487995)
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. (PMID: 16199517)
Genome Biol. 2008;9(9):R137. (PMID: 18798982)
Genome Biol. 2014 Feb 03;15(2):R29. (PMID: 24485249)
Adv Physiol Educ. 2007 Mar;31(1):26-33. (PMID: 17327579)
Cell. 2019 Jun 27;178(1):242-260.e29. (PMID: 31155234)
Nat Rev Genet. 2019 May;20(5):257-272. (PMID: 30696980)
Circulation. 2020 Aug 4;142(5):466-482. (PMID: 32403949)
Nature. 2020 Dec;588(7838):466-472. (PMID: 32971526)
Mol Cell. 2010 May 28;38(4):576-89. (PMID: 20513432)
Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: 23104886)
Aging Male. 2004 Sep;7(3):236-57. (PMID: 15669543)
Sci Rep. 2019 Jun 27;9(1):9354. (PMID: 31249361)
Nat Biotechnol. 2011 Jan;29(1):24-6. (PMID: 21221095)
APL Bioeng. 2018 Mar 20;2(2):026102. (PMID: 31069299)
Clin Chem Lab Med. 2006;44(7):883-7. (PMID: 16776638)
Cell Rep. 2019 Feb 12;26(7):1934-1950.e5. (PMID: 30759401)
Cell. 2019 Jun 13;177(7):1888-1902.e21. (PMID: 31178118)
Bioinformatics. 2009 Mar 15;25(6):765-71. (PMID: 19176553)
Cardiovasc Res. 2013 Dec 1;100(3):402-10. (PMID: 23985902)
Stem Cell Res. 2019 Jan;34:101380. (PMID: 30605840)
Science. 2018 Mar 9;359(6380):1177-1181. (PMID: 29371425)
Bioinformatics. 2009 Aug 15;25(16):2078-9. (PMID: 19505943)
Bioinformatics. 2015 Sep 1;31(17):2912-4. (PMID: 25964631)
Nat Commun. 2020 Nov 30;11(1):6077. (PMID: 33257685)
Nat Commun. 2020 Aug 26;11(1):4267. (PMID: 32848148)
Nucleic Acids Res. 2009 Jul;37(Web Server issue):W305-11. (PMID: 19465376)
Lancet Child Adolesc Health. 2020 Mar;4(3):168-169. (PMID: 31978370)
Nucleic Acids Res. 2012 Sep 1;40(17):e133. (PMID: 22638577)
فهرسة مساهمة: Keywords: chromatin; hormone; human development; progesterone; sexual maturation; transcription factor
المشرفين على المادة: 0 (Receptors, Progesterone)
تواريخ الأحداث: Date Created: 20210308 Date Completed: 20211228 Latest Revision: 20231111
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8055196
DOI: 10.1161/CIRCULATIONAHA.120.051921
PMID: 33682422
قاعدة البيانات: MEDLINE
الوصف
تدمد:1524-4539
DOI:10.1161/CIRCULATIONAHA.120.051921