دورية أكاديمية
أعرض في EDS

Beyond immune checkpoint blockade: emerging immunological strategies.

التفاصيل البيبلوغرافية
العنوان: Beyond immune checkpoint blockade: emerging immunological strategies.
المؤلفون: Kubli SP; Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Berger T; Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Araujo DV; Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Siu LL; Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Mak TW; Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. tmak@uhnres.utoronto.ca.; Department of Immunology, University of Toronto, Toronto, ON, Canada. tmak@uhnres.utoronto.ca.; Department of Pathology, University of Hong Kong, Hong Kong, Hong Kong. tmak@uhnres.utoronto.ca.
المصدر: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2021 Dec; Vol. 20 (12), pp. 899-919. Date of Electronic Publication: 2021 Mar 08.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124171 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-1784 (Electronic) Linking ISSN: 14741776 NLM ISO Abbreviation: Nat Rev Drug Discov Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London, UK : Nature Pub. Group, [2002-
مواضيع طبية MeSH: Immune Checkpoint Inhibitors*/immunology , Immune Checkpoint Inhibitors*/pharmacology , Neoplasms*/drug therapy , Neoplasms*/immunology, Antineoplastic Agents/immunology ; Antineoplastic Agents/pharmacology ; Humans ; Immunotherapy/methods ; Immunotherapy/trends ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology
مستخلص: The success of checkpoint inhibitors has accelerated the clinical implementation of a vast mosaic of single agents and combination immunotherapies. However, the lack of clinical translation for a number of immunotherapies as monotherapies or in combination with checkpoint inhibitors has clarified that new strategies must be employed to advance the field. The next chapter of immunotherapy should examine the immuno-oncology therapeutic failures, and consider the complexity of immune cell-cancer cell interactions to better design more effective anticancer drugs. Herein, we briefly review the history of immunotherapy and checkpoint blockade, highlighting important clinical failures. We discuss the critical aspects - beyond T cell co-receptors - of immune processes within the tumour microenvironment (TME) that may serve as avenues along which new therapeutic strategies in immuno-oncology can be forged. Emerging insights into tumour biology suggest that successful future therapeutics will focus on two key factors: rescuing T cell homing and dysfunction in the TME, and reappropriating mononuclear phagocyte function for TME inflammatory remodelling. New drugs will need to consider the complex cell networks that exist within tumours and among cancer types.
(© 2021. Springer Nature Limited.)
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المشرفين على المادة: 0 (Antineoplastic Agents)
0 (Immune Checkpoint Inhibitors)
تواريخ الأحداث: Date Created: 20210309 Date Completed: 20211222 Latest Revision: 20230130
رمز التحديث: 20240628
DOI: 10.1038/s41573-021-00155-y
PMID: 33686237
قاعدة البيانات: MEDLINE
الوصف
تدمد:1474-1784
DOI:10.1038/s41573-021-00155-y