دورية أكاديمية
Ddx41 loss R-loops in cGAS to fuel inflammatory HSPC production.
| العنوان: | Ddx41 loss R-loops in cGAS to fuel inflammatory HSPC production. |
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| المؤلفون: | Frame JM; Stem Cell Program, Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA., North TE; Stem Cell Program, Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: trista.north@childrens.harvard.edu. |
| المصدر: | Developmental cell [Dev Cell] 2021 Mar 08; Vol. 56 (5), pp. 571-572. |
| نوع المنشور: | Journal Article; Comment |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, Mass. : Cell Press, c2001- |
| مواضيع طبية MeSH: | DEAD-box RNA Helicases*/genetics , DEAD-box RNA Helicases*/metabolism , R-Loop Structures*, DNA Helicases ; Humans ; Nucleotidyltransferases |
| مستخلص: | In this issue of Developmental Cell, Weinreb et al. reveal that loss of the DEAD-box helicase Ddx41 unexpectedly triggers an R-loop-mediated sterile inflammatory cascade which drives HSPC production during embryonic development. Human studies suggest mechanistic conservation for inflammation in DDX41-associated hematologic disease, uncovering a potential route for future therapeutic intervention. Competing Interests: Declaration of Interests The authors declare no competing interests. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment on: Dev Cell. 2021 Mar 8;56(5):627-640.e5. (PMID: 33651979) |
| المشرفين على المادة: | EC 2.7.7.- (Nucleotidyltransferases) EC 3.6.1.- (DDX41 protein, human) EC 3.6.4.- (DNA Helicases) EC 3.6.4.13 (DEAD-box RNA Helicases) |
| تواريخ الأحداث: | Date Created: 20210310 Date Completed: 20210819 Latest Revision: 20210819 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.devcel.2021.02.014 |
| PMID: | 33689767 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1878-1551 |
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| DOI: | 10.1016/j.devcel.2021.02.014 |