دورية أكاديمية
Expression pattern and prognostic value of circadian clock genes in pancreatic adenocarcinoma.
| العنوان: | Expression pattern and prognostic value of circadian clock genes in pancreatic adenocarcinoma. |
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| المؤلفون: | Zhang LL; Department of General Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China., He QK; Department of General Surgery, Ningbo First Hospital, Ningbo, Zhejiang, China., Lv YN; Department of General Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China., Zhang ZJ; Department of General Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China., Xiang YK; Department of General Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Department of General Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. |
| المصدر: | Chronobiology international [Chronobiol Int] 2021 May; Vol. 38 (5), pp. 681-693. Date of Electronic Publication: 2021 Mar 11. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8501362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6073 (Electronic) Linking ISSN: 07420528 NLM ISO Abbreviation: Chronobiol Int Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Oxford ; New York : Pergamon Press, c1984- |
| مواضيع طبية MeSH: | Adenocarcinoma*/genetics , Circadian Clocks*/genetics , Pancreatic Neoplasms*/genetics, Circadian Rhythm/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Prognosis |
| مستخلص: | Accumulating studies indicate that circadian clock genes are pivotal regulators of tumorigenesis and development of various cancers. Nevertheless, their implications in pancreatic adenocarcinoma (PAAD) remain poorly characterized. We investigated the expression pattern of circadian clock genes and evaluated their prognostic values in PAAD. Firstly, we systematically analyzed data from The Cancer Genome Atlas (TCGA) database pertaining to patient clinical information and gene expression data. We found that 19 of 20 circadian clock genes showed significantly different expression levels in comparisons between PAAD and normal tissues. In addition, 10 circadian clock genes with regression coefficients were selected to construct a new risk signature, which was then identified as an independent prognostic factor for PAAD. Mechanistically , circadian clock genes in PAAD may impact the basic state of cells and the composition of tumor-infiltrating immune cells, thus affecting disease prognosis. Finally, we construct a novel prognostic nomogram on the basis of histological nodes and risk score to precisely predict prognosis of patients with PAAD. In conclusion, our study uncovered the important role of circadian clock genes in PAAD and developed a risk signature as a promising prognostic biomarker for patients with PAAD. |
| فهرسة مساهمة: | Keywords: Circadian rhythm; circadian clock genes; pancreatic adenocarcinoma; prognosis’ |
| تواريخ الأحداث: | Date Created: 20210311 Date Completed: 20210803 Latest Revision: 20210803 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/07420528.2021.1890760 |
| PMID: | 33691542 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1525-6073 |
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| DOI: | 10.1080/07420528.2021.1890760 |