دورية أكاديمية
Factors associated with long-term graft survival in pediatric kidney transplant recipients.
| العنوان: | Factors associated with long-term graft survival in pediatric kidney transplant recipients. |
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| المؤلفون: | Anand A; Department of Student Affairs, Baylor College of Medicine, Houston, Texas, USA., Malik TH; Department of Student Affairs, Baylor College of Medicine, Houston, Texas, USA., Dunson J; Department of Student Affairs, Baylor College of Medicine, Houston, Texas, USA., McDonald MF; Department of Student Affairs, Baylor College of Medicine, Houston, Texas, USA., Christmann CR; Department of Student Affairs, Baylor College of Medicine, Houston, Texas, USA., Galvan NTN; Division of Abdominal Transplant, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA., O'Mahony C; Division of Abdominal Transplant, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA., Goss JA; Division of Abdominal Transplant, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA., Srivaths PR; Renal Section, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA., Brewer ED; Renal Section, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA., Rana A; Division of Abdominal Transplant, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA. |
| المصدر: | Pediatric transplantation [Pediatr Transplant] 2021 Jun; Vol. 25 (4), pp. e13999. Date of Electronic Publication: 2021 Mar 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9802574 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-3046 (Electronic) Linking ISSN: 13973142 NLM ISO Abbreviation: Pediatr Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Copenhagen ; Malden, MA : Munksgaard, c1997- |
| مواضيع طبية MeSH: | Graft Survival* , Kidney Transplantation*, Kidney Failure, Chronic/*surgery, Adolescent ; Age Factors ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Health Status Disparities ; Humans ; Infant ; Infant, Newborn ; Kaplan-Meier Estimate ; Logistic Models ; Male ; Protective Factors ; Retrospective Studies ; Risk Factors ; Treatment Outcome |
| مستخلص: | Pediatric kidney transplant recipients generally have good outcomes post-transplantation. However, the younger age and longer life span after transplantation in the pediatric population make understanding the multifactorial nature of long-term graft survival critical. This investigation analyzes factors associated with 10-year survival to identify areas for improvement in patient care. Kaplan-Meier with log-rank test and univariable and multivariable logistic regression methods were used to retrospectively analyze 7785 kidney transplant recipients under the age of 18 years from January 1, 1998, until March 9, 2008, using United Network for Organ Sharing (UNOS) data. Our end-point was death-censored 10-year graft survival after excluding recipients whose grafts failed within one year of transplant. Recipients aged 5-18 years had lower 10-year graft survival, which worsened as age increased: 5-9 years (OR: 0.66; CI: 0.52-0.83), 10-14 years (OR: 0.43; CI: 0.33-0.55), and 15-18 years (OR: 0.34; CI: 0.26-0.44). Recipient African American ethnicity (OR: 0.67; CI: 0.58-0.78) and Hispanic donor ethnicity (OR: 0.82; CI: 0.72-0.94) had worse outcomes than other donor and recipient ethnicities, as did patients on dialysis at the time of transplant (OR: 0.82; CI: 0.73-0.91). Recipient private insurance status (OR: 1.35; CI: 1.22-1.50) was protective for 10-year graft survival. By establishing the role of age, race, and insurance status on long-term graft survival, we hope to guide clinicians in identifying patients at high risk for graft failure. This study highlights the need for increased allocation of resources and medical care to reduce the disparity in outcomes for certain patient populations. (© 2021 Wiley Periodicals LLC.) |
| References: | McDonald SP, Craig JC, Australian and New Zealand Paediatric Nephrology Association. Long-term survival of children with end-stage renal disease. N Engl J Med. 2004;350(26):2654-2662. Van Arendonk KJ, Boyarsky BJ, Orandi BJ, et al. National trends over 25 years in pediatric kidney transplant outcomes. Pediatrics. 2014;133(4):594-601. Chinnakotla S, Verghese P, Chavers B, et al. Outcomes and risk factors for graft loss: lessons learned from 1,056 pediatric kidney transplants at the University of Minnesota. J Am Coll Surg. 2017;224(4):473-486. Gulati A, Sarwal MM. Pediatric renal transplantation: an overview and update. Curr Opin Pediatr. 2010;22(2):189-196. Giessing M, Muller D, Winkelmann B, Roigas J, Loening SA. Kidney transplantation in children and adolescents. Transplant Proc. 2007;39(7):2197-2201. Horslen S, Barr ML, Christensen LL, Ettenger R, Magee JC. Pediatric transplantation in the United States, 1996-2005. Am J Transplant Off J Am Soc Transplant Am Soc Transpl Surg. 2007;7(5 Pt 2):1339-1358. Patzer RE, Mohan S, Kutner N, McClellan WM, Amaral S. Racial and ethnic disparities in pediatric renal allograft survival in the United States. Kidney Int. 2015;87(3):584-592. Foster BJ, Dahhou M, Zhang X, Platt RW, Samuel SM, Hanley JA. Association between age and graft failure rates in young kidney transplant recipients. Transplantation. 2011;92(11):1237-1243. Jarzembowski T, John E, Panaro F, et al. Impact of non-compliance on outcome after pediatric kidney transplantation: an analysis in racial subgroups. Pediatr Transplant. 2004;8(4):367-371. Van Arendonk KJ, James NT, Boyarsky BJ, et al. Age at graft loss after pediatric kidney transplantation: exploring the high-risk age window. Clin J Am Soc Nephrol. 2013;8(6):1019-1026. Hawley CM, Kearsley J, Campbell SB, et al. Estimated donor glomerular filtration rate is the most important donor characteristic predicting graft function in recipients of kidneys from live donors. Transpl Int Off J Eur Soc Organ Transplant. 2007;20(1):64-72. Hanevold CD, Ho P-L, Talley L, Mitsnefes MM. Obesity and renal transplant outcome: a report of the North American Pediatric Renal Transplant Cooperative Study. Pediatrics. 2005;115(2):352-356. Giuliani S, Gamba PG, Chokshi NK, Gasparella P, Murer L, Zanon GF. The effect of donor/recipient body surface area ratio on outcomes in pediatric kidney transplantation. Pediatr Transplant. 2009;13(3):290-299. Van Arendonk KJ, Garonzik Wang JM, Deshpande NA, et al. Practice patterns and outcomes in retransplantation among pediatric kidney transplant recipients. Transplantation. 2013;95(11):1360-1368. Rana A, Ackah RL, Webb GJ, et al. No gains in long-term survival after liver transplantation over the past three decades. Ann Surg. 2019;269(1):20-27. Staley JR, Jones E, Kaptoge S, et al. A comparison of Cox and logistic regression for use in genome-wide association studies of cohort and case-cohort design. Eur J Hum Genet EJHG. 2017;25(7):854-862. Schwartz GJ, Muñoz A, Schneider MF, et al. New equations to estimate GFR in children with CKD. J Am Soc Nephrol. 2009;20(3):629-637. Magee JC, Bucuvalas JC, Farmer DG, Harmon WE, Hulbert-Shearon TE, Mendeloff EN. Pediatric transplantation. Am J Transplant Off J Am Soc Transplant Am Soc Transpl Surg. 2004;4(Suppl 9):54-71. Willoughby LM, Fukami S, Bunnapradist S, et al. Health insurance considerations for adolescent transplant recipients as they transition to adulthood. Pediatr Transplant. 2007;11(2):127-131. White PH. Access to health care: health insurance considerations for young adults with special health care needs/disabilities. Pediatrics. 2002;110(6 Pt 2):1328-1335. Dharnidharka VR, Fiorina P, Harmon WE. Kidney transplantation in children. N Engl J Med. 2014;371(6):549-558. Imamović S, Ljuca F, Imamović G, et al. Influence of donor age on renal graft function in first seven post transplant days. Bosn J Basic Med Sci. 2010;10(1):73-77. Reutzel-Selke A, Jurisch A, Denecke C, et al. Donor age intensifies the early immune response after transplantation. Kidney Int. 2007;71(7):629-636. Giral M, Nguyen JM, Karam G, et al. Impact of graft mass on the clinical outcome of kidney transplants. J Am Soc Nephrol. 2005;16(1):261-268. Shatat IF, Taber DJ, Shrivastava S, et al. Graft outcomes in pediatric kidney transplantation: focus on the role of race. Saudi J Kidney Dis Transplant. 2012;23(4):684. Benfield MR, McDonald RA, Bartosh S, Ho PL, Harmon W. Changing trends in pediatric transplantation: 2001 Annual Report of the North American Pediatric Renal Transplant Cooperative Study. Pediatr Transplant. 2003;7(4):321-335. Amaral S, Patzer R. Disparities, race/ethnicity and access to pediatric kidney transplantation. Curr Opin Nephrol Hypertens. 2013;22(3):336-343. Omoloja A, Mitsnefes M, Talley L, Benfield M, Neu A. Racial differences in graft survival: a report from the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS). Clin J Am Soc Nephrol. 2007;2(3):524-528. Oliver M, Taber D, Pilch N, et al. Evaluation of racial disparities in pediatric kidney transplant. Abstract# A345. Transplantation. 2014;98:498. African American and White Disparities in Pediatric Kidney Transplantation in the United States | Cambridge Quarterly of Healthcare Ethics | Cambridge Core. Kerman RH, Kimball PM, Van Buren CT, Lewis RM, Kahan BD. Possible contribution of pretransplant immune responder status to renal allograft survival differences of black versus white recipients. Transplantation. 1991;51(2):338-342. Kerman RH, Kimball PM, Van Buren CT, Lewis RM, Kahan BD. Stronger immune responsiveness of blacks vs whites may account for renal allograft survival differences. Transplant Proc. 1991;23(1 Pt 1):380-382. Tornatore KM, Meaney CJ, Wilding GE, et al. Influence of sex and race on mycophenolic acid pharmacokinetics in stable African American and Caucasian Renal Transplant Recipients. Clin Pharmacokinet. 2015;54(4):423-434. Macphee IAM, Fredericks S, Tai T, et al. Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and P-glycoprotein correlate with dose requirement. Transplantation. 2002;74(11):1486-1489. Genovese G, Friedman DJ, Ross MD, et al. Association of Trypanolytic ApoL1 variants with kidney disease in African Americans. Science. 2010;329(5993):841-845. Lankarani MM, Assari S. Diabetes, hypertension, obesity, and long-term risk of renal disease mortality: racial and socioeconomic differences. J Diabetes Investig. 2017;8(4):590-599. Aufhauser DD, Peng AW, Murken DR, et al. Impact of prolonged dialysis prior to renal transplantation. Clin Transplant. 2018;32(6):e13260. Goldfarb-Rumyantzev AS, Koford JK, Baird BC, et al. Role of socioeconomic status in kidney transplant outcome. Clin J Am Soc Nephrol. 2006;1(2):313-322. Yoo HY, Thuluvath PJ. Outcome of liver transplantation in adult recipients: influence of neighborhood income, education, and insurance. Liver Transplant Off Publ Am Assoc Study Liver Dis Int Liver Transplant Soc. 2004;10(2):235-243. |
| فهرسة مساهمة: | Keywords: graft survival; long-term outcomes; pediatric kidney transplant; recipient ethnicity |
| تواريخ الأحداث: | Date Created: 20210311 Date Completed: 20220118 Latest Revision: 20220118 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1111/petr.13999 |
| PMID: | 33704871 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1399-3046 |
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| DOI: | 10.1111/petr.13999 |